Research Status and Application Prospects of the Medicinal Mushroom Armillaria mellea

Ren, Sizhu; Gao, Yiping; Li, Hui; Ma, Hongchao; Han, Xuli; Yang, Zitong; Chen, Wenjie

doi:10.1007/s12010-022-04240-9

Cited by 10 publications

(7 citation statements)

References 85 publications

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“…Sixteen metabolites belonging to sesquiterpenoids were identified, but they were not significantly affected by co-culture mode. Moreover, metabolites like lignans, neolignans, and polyketides were identified in our study, but were rarely identified from the mycelia and fruiting bodies in previous studies (Muszynska et al 2011 ; Zhang et al 2015 ; Li et al 2016 ; Ren et al 2022 ), showing the metabolic differences between mycelial exudates, mycelia and fruiting bodies. Furthermore, compared to the separate culture modes, polyketides were generally repressed in C-G co-culture, which might be due to metabolic changes in response to biotic stimulus in the co-culture of Armillaria species with antagonism effect (Nicoletti et al 2004 ; Arredondo-Santoyo et al 2018 ; Dullah et al 2021 ).…”

Section: Discussioncontrasting

confidence: 50%

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

et al. 2023

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The genus Armillaria has high edible and medical values, with zones of antagonism often occurring when different species are paired in culture on agar media, while the antagonism-induced metabolic alteration remains unclear. Here, the metabolome of mycelial exudates of two Chinese Armillaria biological species, C and G, co-cultured or cultured separately was analysed to discover the candidate biomarkers and the key metabolic pathways involved in Armillaria antagonists. A total of 2,377 metabolites were identified, mainly organic acids and derivatives, lipids and lipid-like molecules, and organoheterocyclic compounds. There were 248 and 142 differentially expressed metabolites between group C-G and C, C-G, and G, respectively, and fourteen common differentially expressed metabolites including malate, uracil, Leu-Gln-Arg, etc. Metabolic pathways like TCA cycle and pyrimidine metabolism were significantly affected by C-G co-culture. Additionally, 156 new metabolites (largely organic acids and derivatives) including 32 potential antifungal compounds, primarily enriched into biosynthesis of secondary metabolites pathways were identified in C-G co-culture mode. We concluded that malate and uracil could be used as the candidate biomarkers, and TCA cycle and pyrimidine metabolism were the key metabolic pathways involved in Armillaria antagonists. The metabolic changes revealed in this study provide insights into the mechanisms underlying fungal antagonists.

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Section: Discussioncontrasting

confidence: 50%

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

et al. 2023

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“…On the other hand, armillaria has been identified as one of the prevalent diseases contributing to chronic root rot in woody plants. 52 These fungi possess saprophytic and facultative parasitic characteristics, allowing them to thrive on tree roots and lower trunks, resulting in significant harm to both coniferous and broad-leaved trees. Although a targeted solution is currently absent, soil disinfection has emerged as a widely adopted and effective protective measure.…”

Section: Discussion and Future Application Of Ammentioning

confidence: 99%

Critical review of the phytochemical profiles and health-promoting effects of the edible mushroomArmillaria mellea

Huang,

2023

Food Funct.

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“…29−31 MOFs consist of metal cores and organic ligands, and due to their high active surface, adjustable cavities, and resistance to high temperature and chemicals, they are a suitable substrate for enzyme immobilization. 32,33 In recent years, enzymes have been used as a powerful method in synthesis of organic compounds. 34 Enzyme promiscuity in chemical reactions has been one of the fascinating debates about enzymes.…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis of 1,3,5-Trisubstitued Pyrazoles via Immobilized Thermomyces lanuginosus Lipase (TLL) on a Metal–Organic Framework

Rangraz,

Amini,

Habibi

2024

ACS Omega

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A regioselective enzyme-catalyzed system is selected for the synthesis of 1,3,5-trisubstituted pyrazole derivatives by adding phenyl hydrazines, nitroolefins, and benzaldehydes. The reaction is performed in a one-pot vessel with a yield ranging from 49 to 90%. TLL@MMI, immobilized Thermomyces lanuginosus lipase (TLL) on a multivariate of MOF-5/IRMOF-3 (MMI), showed good performance for the catalysis of this reaction. The prepared biocatalyst was characterized by FTIR, XRD, SEM, and EDX. The thermal and solvent stability of TLL@MMI was investigated in MeOH and EtOH after 24 h incubation. In the presence of 100% concentrations of EtOH, TLL@MMI has 80% activity.

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Research Status and Application Prospects of the Medicinal Mushroom Armillaria mellea

Cited by 10 publications

References 85 publications

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

Critical review of the phytochemical profiles and health-promoting effects of the edible mushroomArmillaria mellea

One-Pot Synthesis of 1,3,5-Trisubstitued Pyrazoles via Immobilized Thermomyces lanuginosus Lipase (TLL) on a Metal–Organic Framework

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