Research Trends in the Efficacy of Stem Cell Therapy for Hepatic Diseases Based on MicroRNA Profiling

Kweon, Minyeoung; Kim, Jae Yeon; Jun, Ji Hye; Kim, Gi Jin

doi:10.3390/ijms22010239

Cited by 6 publications

(3 citation statements)

References 170 publications

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“…MiRNAs are involved in the regulation of hepatocyte proliferation, differentiation, and metabolic activity. A review by Kweon et al described in detail the spectrum of miRNAs that are produced in the liver and are critical for different liver functions [172].…”

Section: Involvement Of Mirnas In the Anti-apoptotic Effects Of Mscsmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

Kholodenko,

Yarygin

2023

IJMS

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Liver diseases, characterized by high morbidity and mortality, represent a substantial medical problem globally. The current therapeutic approaches are mainly aimed at reducing symptoms and slowing down the progression of the diseases. Organ transplantation remains the only effective treatment method in cases of severe liver pathology. In this regard, the development of new effective approaches aimed at stimulating liver regeneration, both by activation of the organ’s own resources or by different therapeutic agents that trigger regeneration, does not cease to be relevant. To date, many systematic reviews and meta-analyses have been published confirming the effectiveness of mesenchymal stromal cell (MSC) transplantation in the treatment of liver diseases of various severities and etiologies. However, despite the successful use of MSCs in clinical practice and the promising therapeutic results in animal models of liver diseases, the mechanisms of their protective and regenerative action remain poorly understood. Specifically, data about the molecular agents produced by these cells and mediating their therapeutic action are fragmentary and often contradictory. Since MSCs or MSC-like cells are found in all tissues and organs, it is likely that many key intercellular interactions within the tissue niches are dependent on MSCs. In this context, it is essential to understand the mechanisms underlying communication between MSCs and differentiated parenchymal cells of each particular tissue. This is important both from the perspective of basic science and for the development of therapeutic approaches involving the modulation of the activity of resident MSCs. With regard to the liver, the research is concentrated on the intercommunication between MSCs and hepatocytes under normal conditions and during the development of the pathological process. The goals of this review were to identify the key factors mediating the crosstalk between MSCs and hepatocytes and determine the possible mechanisms of interaction of the two cell types under normal and stressful conditions. The analysis of the hepatocyte–MSC interaction showed that MSCs carry out chaperone-like functions, including the synthesis of the supportive extracellular matrix proteins; prevention of apoptosis, pyroptosis, and ferroptosis; support of regeneration; elimination of lipotoxicity and ER stress; promotion of antioxidant effects; and donation of mitochondria. The underlying mechanisms suggest very close interdependence, including even direct cytoplasm and organelle exchange.

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Section: Involvement Of Mirnas In the Anti-apoptotic Effects Of Mscsmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

Kholodenko,

Yarygin

2023

IJMS

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“…A single miRNA can potentially regulate the expression of multiple genes, and conversely, a gene can be targeted by numerous miRNAs. Because of this property, miRNAs have been reported to be dysregulated in diverse human diseases ( Ardekani & Naeini, 2010 ; Chung et al, 2021 ; Climent et al, 2020 ; Juzwik et al, 2019 ; Kweon et al, 2020 ; Lam et al, 2018 ; Ojha et al, 2019 ; Sell et al, 2020 ; Tufekci et al, 2014 ; Zhao et al, 2016 ). Due to their prominent role in diseases, miRNAs are regarded as powerful diagnostic and prognostic biomarkers ( Condrat et al, 2020 ; Gandellini, Giovannetti & Nicassio, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of neoplasm-specific signatures of miRNA interactions by employing a systems biology approach

Bonab

Asfa

Kontou

et al. 2022

PeerJ

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MicroRNAs represent major regulatory components of the disease epigenome and they constitute powerful biomarkers for the accurate diagnosis and prognosis of various diseases, including cancers. The advent of high-throughput technologies facilitated the generation of a vast amount of miRNA-cancer association data. Computational approaches have been utilized widely to effectively analyze and interpret these data towards the identification of miRNA signatures for diverse types of cancers. Herein, a novel computational workflow was applied to discover core sets of miRNA interactions for the major groups of neoplastic diseases by employing network-based methods. To this end, miRNA-cancer association data from four comprehensive publicly available resources were utilized for constructing miRNA-centered networks for each major group of neoplasms. The corresponding miRNA-miRNA interactions were inferred based on shared functionally related target genes. The topological attributes of the generated networks were investigated in order to detect clusters of highly interconnected miRNAs that form core modules in each network. Those modules that exhibited the highest degree of mutual exclusivity were selected from each graph. In this way, neoplasm-specific miRNA modules were identified that could represent potential signatures for the corresponding diseases.

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“…MicroRNAs (miRNAs) are single-stranded small non-coding RNAs of approximately 19 to 28 nucleotides that participate in regulating the expression of genes through binding to the 3 untranslated region (3 -UTR) of target messenger RNAs (mRNAs) [8]. miRNAs are important in a variety of biological mechanisms such as differentiation, development, and cell proliferation [9]. miRNA is transcribed by RNA polymerases II or III to primary miRNA with a cap and a poly-A tail.…”

Section: Introductionmentioning

confidence: 99%

Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis

et al. 2021

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Background: Carotid artery stenosis is a dynamic process associated with an increased risk of cardiovascular events. However, knowledge of biomarkers useful for identifying and quantifying high-risk carotid plaques associated with the increased incidence of cerebrovascular events is insufficient. Therefore, the objectives of this study were to evaluate the expression of ATP binding cassette transporter 1 (ABCA1) and validate its target microRNA (miRNA) candidates in human carotid stenosis arteries to identify its potential as a biomarker. Methods: In human carotid stenosis arterial tissues and plasma, the expression of ABCA1 and its target miRNAs (miRNA-33a-5p, 33b-5p, and 148a-3p) were evaluated by quantitative real time-polymerase chain reaction (qRT-PCR), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Results: The expression of ABCA1 was significantly decreased in the plasma of stenosis patients, but its expression was not different in arterial tissues (p < 0.05). However, significantly more target miRNAs were secreted by stenosis patients than normal patients (p < 0.05). Interestingly, lipotoxicity induced by the oleic and palmitic acid (OAPA) or lipopolysaccharide (LPS) treatment of human umbilical vein endothelial cells (HUVECs) dramatically enhanced the gene expression of adipogenic and inflammatory factors, whereas ABCA1 expression was significantly decreased. Conclusions: Therefore, miRNA-33a-5p, 33b-5p, and 148a-3p represent possible biomarkers of carotid artery stenosis by directly targeting ABCA1.

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Research Trends in the Efficacy of Stem Cell Therapy for Hepatic Diseases Based on MicroRNA Profiling

Cited by 6 publications

References 170 publications

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

Identification of neoplasm-specific signatures of miRNA interactions by employing a systems biology approach

Expression of miRNAs Targeting ATP Binding Cassette Transporter 1 (ABCA1) among Patients with Significant Carotid Artery Stenosis

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