Research trends in ulcerative colitis: A bibliometric and visualized study from 2011 to 2021

Abstract

Background: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease with repeated relapses and remissions. Despite decades of effort, numerous aspects, including the initiating event and pathogenesis of UC, still remain ambiguous, which requires ongoing investigation. Given the mass of publications on UC, there are multidimensional challenges to evaluating the scientific impact of relevant work and identifying the current foci of the multifaceted disease. Accordingly, herein, we aim to assess the global growth of UC research production, analyze patterns of research areas, and evaluate trends in this area.Methods: The Web of Science Core Collection of Clarivate Analytics was searched for articles related to UC published from 2011 to 2021. Microsoft Office Excel 2019 was used to visualize the number of publications over time. Knowledge maps were generated using CiteSpace and VOSviewer to analyze collaborations among countries, institutions, and authors and to present the journey of UC research as well as to reveal the current foci of UC research.Results: A total of 5,088 publications were evaluated in the present study. China had the most publications (1,099, 22.5%). Univ Calif San Diego was the most productive institution (126, 2.48%). William J Sandborn published the greatest number of articles (100, 1.97%). Toshifumi Hibi was the most influential author in the field with a betweenness centrality of 0.53. Inflammatory bowel diseases was identified as the most prolific journal (379, 7.45%). Gastroenterology was the most co-cited journal (3,730, 4.02%). “Vedolizumab,” “tofacitinib,” “Faecalibacterium prausnitzii,” “fecal microbiota transplantation (FMT),” “toll-like receptor 4,” and “nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome” were considered the hot topics.Conclusion: In UC research, manuscripts that had high impacts on the scientific community provided an evidence base. UC therapy has entered the era of personalized and precision therapy. As research on FMT, anti-integrin antibodies, Janus kinase inhibitors, and anti-tumor necrosis factor drugs continues to grow, their use in the clinical setting may also expand.

Frontiers and hotspots evolution in cytokine storm: A bibliometric analysis from 2004 to 2022

“…Nodes displaying a betweenness centrality greater than 0.1 are connected to over 10 % of other nodes. These nodes exert substantial influence through the significant resources they control within their networks [ 33 ]. The United States, China, and Englandwere the primary research centers for cytokine storms, and had close cooperation with Italy, Canada, and Germany.…”

A bibliometric analysis of insomnia in adolescent

“…Co–citation occurs when two journals are referenced in one or more identical papers at the same time. In this case, the two journals cited by the same third journal are thought to share intellectual affinity ( 43 ). Journal co–citation analysis may be used to identify the journals that are significant in a certain topic.…”

A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century

“…Such nodes hold a crucial position and exerted a substantial influence on other nodes. [283] They were widely recognized as critical and central within the network. [276,284,285] In addition, the Q score, which ranges from 0 to 1, was used to assess the structure of a network.…”

“…Such nodes hold a crucial position and exerted a substantial influence on other nodes. [ 283 ] They were widely recognized as critical and central within the network. [ 276,284,285 ]…”