Research Update: Past Substance Abuse and Clinical Course of Schizophrenia

Zisok, Sideny; Heaton, Robert; Moranville, John T.; Kuck, Julie; Jernigan, Terry L.; Braff, David L.

doi:10.3109/10884609209026890

Cited by 25 publications

(31 citation statements)

References 9 publications

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“…When abstinent, however, such patients have less severe psychotic symptoms and better social functioning than those who have never abused substances. 31,32 It is important not to overgeneralize these findings, for several reasons. First, our study was clinical, not epidemiologic, and the sample was not intended to be broadly representative of schizophrenic persons.…”

Section: Discussionmentioning

confidence: 99%

Disability Income, Cocaine Use, and Repeated Hospitalization among Schizophrenic Cocaine Abusers — A Government-Sponsored Revolving Door?

et al. 1995

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Among cocaine-abusing schizophrenic persons, the cyclic pattern of drug use strongly suggests that it is influenced by the monthly receipt of disability payments. The consequences of this cycle include the depletion of funds needed for housing and food, exacerbation of psychiatric symptoms, more frequent psychiatric hospitalization, and a high rate of homelessness. The troubling irony is that income intended to compensate for the disabling effects of severe mental illness may have the opposite effect.

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Section: Discussionmentioning

confidence: 99%

Disability Income, Cocaine Use, and Repeated Hospitalization among Schizophrenic Cocaine Abusers — A Government-Sponsored Revolving Door?

et al. 1995

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“…Some investigators suggest that cannabis is related to poorer outcome, to higher hospitalization rates and to behavioral dyscontrol (Linszen et al 1994;Owen et al 1996; Barry et al 1996), but others do not support this (Zisook et al 1992;Cantor-Graae et al 2001).…”

Section: Introductionmentioning

confidence: 91%

Cannabis and schizophrenia: impact on onset, course, psychopathology and outcomes

Bersani¹,

Orlandi

Kotzalidis

et al. 2002

European Archives of Psychiatry and Clinical Neurosciences

150

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Cannabis consuming schizophrenic patients are younger at onset, are likely to have started abuse before onset of schizophrenia and show more prominent positive symptoms than nonabusers. It has been suggested that cannabis is a risk-factor for schizophrenia. Our aim was to assess prevalence and pattern of cannabis use in 125 chronic male schizophrenic subjects and its impact on socioepidemiological and clinical variables as well as which disorder precedes the other in onset. Assessment of consumption was made with a semi-structured clinical interview. Clinical status was assessed by means of the SANS, SAPS, PANSS and BPRS scales. Cannabis consumption was found in 54 subjects (43%), 66.7% of whom started it at least three years before onset of schizophrenia. Consumers were younger and with lower negative symptoms, specially abusers and polysubstance abusers. Family history positive for psychosis was more frequent in consumers, especially when consumption started before onset of schizophrenia. Subjects whose onset of schizophrenia preceded the beginning of cannabis abuse had more positive symptoms than those who started abuse before the onset of schizophrenia. On these grounds, our sample could be subdivided into two main groups, one that uses substances to counter distressing symptoms of schizophrenia and another in which cannabis might be one of the factors predisposing to the disease; the former had less negative symptoms than nonabusers. Our data support both heterogeneity of schizophrenia and genetic susceptibility to environmental agents.

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“…One study found no baseline differences in psychopathology between cannabis users and nonusers (Zisook et al, 1992). One study found no baseline differences in psychopathology between cannabis users and nonusers (Zisook et al, 1992).…”

Section: Longitudinal and Observational Studiesmentioning

confidence: 99%