Resection of the largest reported hepatic small vessel neoplasm

Walcott-Sapp, Sarah; Tang, Ephraim; Kakar, Sanjay; Shen, Jian; Hansen, Paul

doi:10.1016/j.humpath.2018.01.013

Cited by 21 publications

(21 citation statements)

References 11 publications

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“…In a recent report on 2 cases of histologically confirmed hepatic small vessel neoplasm, contrast-enhanced MRI was performed in 1 patient and showed strong enhancement in the arterial phase with continuous and complete enhancement in the venous phase [6]. A similar pattern of enhancement was reported on the CT scan of a hepatic small vessel neoplasm with marked enhancement in the arterial phase and progressive filling in the late phase without washout [7]. In contrast to hemangiomas, which are hypointense on T1-and hyperintense on T2-weighted MRI, the hepatic small vessel neoplasm was nearly isointense in both series (▶ Fig.…”

Section: T1 T1 T1 T1supporting

confidence: 52%

“…A cutoff of 10 % ki67 positivity has been reported with a 100 % sensitivity and specificity for the discrimination between hepatic small vessel neoplasm and hemangiosarcoma [2]. In accordance to the low mitotic activity of published cases, the presented tumor showed neither a significantly elevated ki67 proliferation index nor p53 overexpression [2,6,7].…”

Section: T1 T1 T1 T1mentioning

confidence: 64%

“…Since the term has only recently been coined [2], clinical reports are rare [3,6,7], and retrospective (re-)classification of similar cases is hampered by incomplete histopathological descriptions, different imaging modalities, and a varying focus of the reported cases.…”

Section: Discussionmentioning

confidence: 99%

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Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver

et al. 2019

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A 37-year-old male patient with Crohn’s disease and multiple liver hemangiomas was referred to our hospital for an atypical hypervascular hepatic lesion detected on an external magnetic resonance imaging (MRI) scan. The patient was otherwise well and had no history of any liver disease. Liver values and tumor markers were normal. Contrast-enhanced ultrasound confirmed multiple hemangiomas in different liver segments and a hypervascular tumor with a hypovascular rim in segment II/IV. Repeat MRI showed a strongly enhancing neoplasm of 2.6 cm with a texture distinctly different from the otherwise relatively uniform hemangiomas, without evidence of interim growth. Ultrasound-guided biopsy revealed a hepatic small vessel neoplasm. Due to the unknown malignant potential, atypical segmental surgical resection was performed. Final histopathological analysis confirmed the complete resection of the lesion. The postoperative course was uneventful.

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Section: T1 T1 T1 T1supporting

confidence: 52%

Section: T1 T1 T1 T1mentioning

confidence: 64%

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Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver

et al. 2019

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“…Further analysis indicated the emergence of advanced malignancies including epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) appearance, both occurring in parallel with the EET process, as supported by the upregulation of CD31 and CD34, vascular lineage markers indicative of neoangiogenesis 38 (Fig. 5g ; Supplementary Fig.…”

Section: Resultsmentioning

confidence: 95%

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

et al. 2018

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Chemotherapy and radiation not only trigger cancer cell apoptosis but also damage stromal cells in the tumour microenvironment (TME), inducing a senescence-associated secretory phenotype (SASP) characterized by chronic secretion of diverse soluble factors. Here we report serine protease inhibitor Kazal type I (SPINK1), a SASP factor produced in human stromal cells after genotoxic treatment. DNA damage causes SPINK1 expression by engaging NF-κB and C/EBP, while paracrine SPINK1 promotes cancer cell aggressiveness particularly chemoresistance. Strikingly, SPINK1 reprograms the expression profile of cancer cells, causing prominent epithelial-endothelial transition (EET), a phenotypic switch mediated by EGFR signaling but hitherto rarely reported for a SASP factor. In vivo, SPINK1 is expressed in the stroma of solid tumours and is routinely detectable in peripheral blood of cancer patients after chemotherapy. Our study substantiates SPINK1 as both a targetable SASP factor and a novel noninvasive biomarker of therapeutically damaged TME for disease control and clinical surveillance.

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“…While in our series sizes varied from 0.2 to 5.5 cm (average, 2.1 cm), Walcott-Sapp et al 82 have just reported a resected hepatic tumor occupying the entire left lobe and anterior section of the right liver measuring 15.9 by 14.0 by 6.7 cm 3 tan-red mottled irregular ill-defined fibrotic mass, up to now the largest published HSVN.…”

Section: Hepatic Small Vessel Neoplasmmentioning

confidence: 55%

Malignant Vascular Tumors of the Liver in Adults

Alves

Rimola

2018

Semin Liver Dis

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Hepatic angiosarcoma and epithelioid hemangioendothelioma (EHE) might be clinically considered a spectrum since, although more frequently presenting indolent behavior, EHE occasionally evolves to high-grade neoplasms. However, in most circumstances, pathological and immunohistochemical patterns define this differential diagnosis. More recently, molecular pathways for angiosarcoma and for EHE from other organs and from soft tissue have been proved different, paving the way for future morpho-molecular assessment of their hepatic counterpart. The frequency of liver involvement by Kaposi sarcoma in HIV-infected patients is lower nowadays. Histological findings and immunostaining for HHV-8 Ag are characteristic. Hepatic small vessel neoplasms have been recently recognized as important mimickers of angiosarcoma. The criteria for this differential diagnosis and the clinical behavior, up to now considered favorable, must be further studied.

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Resection of the largest reported hepatic small vessel neoplasm

Cited by 21 publications

References 11 publications

Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver

Case report: a rare cause of a hypervascular nodule in a noncirrhotic liver

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

Malignant Vascular Tumors of the Liver in Adults

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