Reshaped as polyester-based nanoparticles, gallic acid inhibits platelet aggregation, reactive oxygen species production and multi-resistant Gram-positive bacteria with an efficiency never obtained

Abstract

A gallic acid nanoformulation acts as a strong platelet aggregation, ROS and bacterial growth inhibitor.

Polyester-Based Dendrimer Nanoparticles Combined with Etoposide Have an Improved Cytotoxic and Pro-Oxidant Effect on Human Neuroblastoma Cells

“…Dendron intermediates were synthetized to achieve dendrimer 4, i.e., D4BnA, D4BnOH, D5BnA, and D5ACOOH were prepared as previously reported [57][58][59] and their chemical structures are available in Figure S1. Fifth generation polyester-based biodegradable dendrimer 4 was prepared according to the previously reported procedures shown in Scheme 1 (Section 3) [60][61][62]. Its characterization data, including copies of FTIR, 1 H, and 13 C NMR spectra, are available in Table S1 and in Figure S2.…”

“…Dendrimer 4, selected as host carrier to complex ETO, was prepared as previously described, according to Scheme 1 [60][61][62].…”

“…Complying with the most modern trends that suggest using nanotechnology, dendrimer nanoparticles were selected as a device to obtain an ETO drug delivery system (DDS) with a more promising Z-potential and an improved DL% in comparison to that previously achieved. In this regard, a fifth generation polyester-based dendrimer (4) that was successful in enhancing stability, reducing fast metabolism, and improving several beneficial activity of a natural polyphenol was prepared as previously described [57][58][59][60][61][62].…”

Development of a Fast, Low‐Cost, Conservative and Ecological Method for Quantifying Gallic Acid in Polymeric Formulations by FTIR Spectroscopy in Solution

“…GA attracts the interest of researchers mainly for its antioxidant capacity and ability in counteracting oxidative stress (OS) and correlated diseases as cancer, HIV, ulcer, inflammation, bacterial infections, fungi infections and neurodegenerative disorders …”

“…In the last decade, several natural or synthetic polymers, including acryloyldimethyl taurate with propylene glycol, polylactic‐co‐glycolic acid (PLGA), polyethylene glycol (PEG), chitosane, cyclodextrins, dextrane and dendrimers such as poly(amidoamine) (PAMAM) or polyester‐based ones have emerged as promising carrier systems for GA.…”