Reshaping the Gut Microbiota Through Lifestyle Interventions in Women with PCOS: A Review

Ramadurai, Sivasankari; Balasundaram, Usha

doi:10.1007/s12088-022-01019-8

Cited by 7 publications

(4 citation statements)

References 120 publications

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“…A predominância de alteração de permeabilidade em estudantes do sexo feminino em detrimento ao sexo masculino pode ser explicada pelas alterações endócrinas, como a síndrome dos ovários policísticos, alterações hormonais durante o ciclo menstrual que desempenham um papel importante relacionado a microbiota intestinal (Ferreira e Araújo, 2020;Gu et al, 2022;Pontes et al, 2022;Sivasankari;Usha, 2022). Importante destacar que os transtornos alimentares e alterações na percepção de imagem são mais comuns em mulheres e que dietas restritivas podem alterar diversidade microbiana considerando a limitação de substratos oferecidos pela dieta (Ferreira e Araújo, 2020;Gu et al, 2022;.…”

Section: Resultsunclassified

Avanços & Perspectivas em Saúde

2023

Avanços &Amp; Perspectivas Em Saúde

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Graduação em Nutrição (2009). Especialista em Nutrição Clínica no Instituto de Medicina Integral Prof. Fernando Figueira (2010). Especialista em terapia nutricional em pacientes renais pelo Instituto Cristina Martins (2013). Mestre e doutora em Bioquímica pela Universidade Federal do Rio Grande do Norte. Experiência nas disciplinas de Nutrição Experimental, Dietoterapia I e II, avaliação nutricional e técnica dietética. Docente do Curso de Nutrição do Centro Universitário Christus (UNICHRISTUS) e Coordenadora de pesquisa, extensão e monitoria. Atuação nas linhas de pesquisa envolvendo potencial multifuncional de compostos bioativos (in silico e in vitro) e cuidado nutricional nas DCNT. Currículo Lattes: http://lattes.cnpq.br/1352905640097175 Organizadora Greicy Coelho Arraes Possui graduação em Fisioterapia pela Universidade de Fortaleza (2010). Possui mestrado em Farmacologia (conceito CAPES 7) pela Universidade Federal do Ceará, onde desenvolveu pesquisa na linha da neurofarmacologia com ênfase em Transtornos neuropsiquiátricos. Doutora pelo programa de pós-graduação pelo Departamento de Fisiologia e Farmacologia da Faculdade de Medicina na Universidade Federal do Ceará na linha de pesquisa em Transtornos psiquiátricos neurodesenvolvimentais sobre a influência do enriquecimento ambiental. Atualmente, é professora do Centro Universitário CHRISTUS na cidade de Fortaleza (CE) e na Faculdade Christus no município do Eusébio (CE), contribuindo nos cursos de Enfermagem e Nutrição. Membro do Corpo Editorial da editora IMAC (Editora Associada e IBEC Brasil).

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Section: Resultsunclassified

Avanços & Perspectivas em Saúde

2023

Avanços &Amp; Perspectivas Em Saúde

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“…Therefore, manipulation of the gut microbiota by fecal microbiota transplantation (FMT), probiotics, prebiotic, or commensal bacteria improved the PCOS phenotype ( Qi et al, 2019 , 2021 ; Han et al, 2021 ; Rodriguez Paris et al, 2022 ). Though there are many variables influencing the traits of intestinal flora, it can be stated that a significant share of these variables is related to diet and activity ( Sivasankari and Usha, 2022 ). However, as a molecule of exercise sensor, there was only one published article regarding the influence of irisin on gut microbiome and metabolomics in ulcerative colitis animal models ( Huangfu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics

Yang,

Deng,

Zhou

et al. 2024

Front. Microbiol.

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IntroductionFolliculogenesis and oligo/anovulation are common pathophysiological characteristics in polycystic ovary syndrome (PCOS) patients, and it is also accompanied by gut microbiota dysbiosis. It is known that physical activity has beneficial effects on improving metabolism and promoting ovulation and menstrual cycle disorder in PCOS patients, and it can also modulate the gastrointestinal microbiota in human beings. However, the mechanism remains vague. Irisin, a novel myokine, plays a positive role in the mediating effects of physical activity.MethodsMice were randomly divided into the control group, PCOS group and PCOS+irisin group. PCOS model was induced by dehydroepiandrosterone (DHEA) and high-fat diet (HFD). The PCOS+irisin group was given irisin 400μg/kg intraperitoneal injection every other day for 21 days. The serum sex hormones were measured by radioimmunoassay. Hematoxylin and Eosin (H&E) Staining and immunohistochemistry (IHC) were conducted on ovarian tissue. The feces microbiota and metabolomic characteristics were collected by 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC–MS).ResultsIn this study, we demonstrated that irisin supplementation alleviated reproductive endocrine disorders of PCOS mice, including estrous cycle disturbance, ovarian polycystic degeneration, and hyperandrogenemia. Irisin also improved the PCOS follicles dysplasia and ovulation disorders, while it had no significant effect on the quality of oocytes. Moreover, irisin could mitigate the decreased bacteria of Odoribacter and the increased bacteria of Eisenbergiella and Dubosiella in PCOS mice model. Moreover, irisin could alleviate the increased fecal metabolites: Methallenestril and PS (22:5(4Z,7Z,10Z,13Z,16Z)/ LTE4).ConclusionThese results suggest that irisin may alleviate the status of PCOS mice model by modulating androgen-induced gut microbiota dysbiosis and fecal metabolites. Hence, our study provided evidence that irisin may be considered as a promising strategy for the treatment of PCOS.

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“…Our study provided novel evidence that the SUA level decreases with increase in healthy lifestyle behaviors. Lifestyle interventions can reshape the gut microbiota [ 37 ]. Faecalibacterium [ 38 ] and Clostridium [ 39 ], as an intestinal microbial preparation, can produce butyric acid by fermenting dietary fiber in the intestine.…”

Section: Discussionmentioning

confidence: 99%

Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid

He,

Shao,

et al. 2023

Nutr Metab (Lond)

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Background Whether and to what extent serum uric acid (SUA) mediates the association between combined lifestyle behaviors and type 2 diabetes mellitus (T2DM) remain unclear. This study aimed to investigate the role of SUA in the relationship between healthy lifestyle scores (HLS) and the incidence of T2DM. Methods This prospective study used data from Zhejiang Metabolic Syndrome cohort. A HLS (5-point scale including healthy waist circumference (WC), never smoking, high physical activity, healthy diet and moderate alcohol intake) was estimated in 13,919 participants, who had SUA at baseline examination in 2009–2014, and were followed-up to 2021–2022 to ascertain incident of T2DM. Cox proportional hazards models and mediation analysis were used to examine the associations between HLS, SUA and T2DM. Results We included 13,919 participants aged 18 years or older without diabetes at baseline (mean age 54.6 [SD 13.9] years, 58.7% female). During a median follow-up of 9.94 years, 645 cases of T2DM occurred. Compared with participants with a poor HLS, those with 4–5 low-risk lifestyle factors showed a 60% reduction in the risk of developing T2DM (adjusted HR, 0.40; 95% CI: 0.28–0.57). Further, the population-attributable risk percent (95% CI) of T2DM for poor adherence to the overall healthy lifestyle (< 4 low-risk factors) was 43.24% (30.02%, 56.46%). The HLS was inversely associated with SUA level. With per score increased in HLS, the beta (95% CI) of SUA (log transformed) was − 0.03 (− 0.03, − 0.02), and the odds ratio (95% CI) of hyperuricemia was 0.82 (0.77, 0.86). The relationship between the HLS and risk of T2DM was mediated by SUA with a 13.06% mediation effect. There was no significant combined effect of HLS and SUA on risk of T2DM (P = 0.097). Conclusions The relationship between overall healthy lifestyle behaviors and T2DM was reconfirmed and the association appeared to be mediated by SUA. The mediation effect of baseline SUA was more pronounced among women who were below 60 years old.

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Reshaping the Gut Microbiota Through Lifestyle Interventions in Women with PCOS: A Review

Cited by 7 publications

References 120 publications

Avanços & Perspectivas em Saúde

Avanços & Perspectivas em Saúde

Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics

Healthy lifestyle scores associate with incidence of type 2 diabetes mediated by uric acid

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