Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling

Summers, Megan; Richmond, Bradley W.; Menon, Swapna; Sheridan, Ryan M.; Kropski, Jonathan A.; Majka, Sarah A; Taketo, M.; Bastarache, Julie A.; West, James; Langhe, Stijn De; Geraghty, Patrick; Klemm, Dwight J.; Chu, Hong Wei; Friedman, Rachel S.; Tao, Yuankai K.; Foronjy, Robert; Majka, Susan M.

doi:10.1096/fj.202000629r

Cited by 17 publications

(20 citation statements)

References 111 publications

(260 reference statements)

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“…In addition, Dkk3 is able to signal by binding the CXCR7 receptor to stimulate these Sca-1 + progenitor cells' migration [118]. Recent results on ABCG2 + mesenchymal cells suggest that Wnt activation prevents differentiation of these progenitor cells towards EC through β-catenin activation [119]. This is in line with other studies in which inhibition of Wnt signaling enhanced the angiogenic properties of endothelial-colony-forming cells [120] and stimulated the release of vasculogenic progenitor cells from bone marrow.…”

Section: Wntsupporting

confidence: 72%

Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension

Dierick

Solinc

Bignard

et al. 2021

Cells

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Pulmonary arterial hypertension (PAH) is characterized by an important occlusive vascular remodeling with the production of new endothelial cells, smooth muscle cells, myofibroblasts, and fibroblasts. Identifying the cellular processes leading to vascular proliferation and dysfunction is a major goal in order to decipher the mechanisms leading to PAH development. In addition to in situ proliferation of vascular cells, studies from the past 20 years have unveiled the role of circulating and resident vascular in pulmonary vascular remodeling. This review aims at summarizing the current knowledge on the different progenitor and stem cells that have been shown to participate in pulmonary vascular lesions and on the pathways regulating their recruitment during PAH. Finally, this review also addresses the therapeutic potential of circulating endothelial progenitor cells and mesenchymal stem cells.

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Section: Wntsupporting

confidence: 72%

Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension

Dierick

Solinc

Bignard

et al. 2021

Cells

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“…The side population is characterized by their ability to efflux fluorescent dyes via ATP‐binding transporters such as ABCG2; and a recent study on lung resident ABCG2 + cells has identified them as mesenchymal vascular progenitors with capacity to modulate adaptive repair angiogenesis in the lung. 63 …”

Section: Markers For Endothelial Progenitorsmentioning

confidence: 99%

Current Concepts on Endothelial Stem Cells Definition, Location, and Markers

Chambers

Pathak

Pedrini

et al. 2021

Stem Cells Translational Medicine

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Ischemic vascular disease is a major cause of mortality and morbidity worldwide, and regeneration of blood vessels in perfusion-deficient tissues is a worthwhile therapeutic goal. The idea of delivering endothelial stem/progenitor cells to repair damaged vasculature, reperfuse hypoxic tissue, prevent cell death, and consequently diminish tissue inflammation and fibrosis has a strong scientific basis and clinical value. Various labs have proposed endothelial stem/progenitor cell candidates. This has created confusion, as there are profound differences between these cell definitions based on isolation methodology, characterization, and reparative biology. Here, a stricter definition based on stem cell biology principles is proposed. Although preclinical studies have often been promising, results from clinical trials have been highly contradictory and served to highlight multiple challenges associated with disappointing therapeutic benefit. This article reviews recent accomplishments in the field and discusses current difficulties when developing endothelial stem cell therapies. Emerging evidence that disputes the classic view of the bone marrow as the source for these cells and supports the vascular wall as the niche for these tissue-resident endothelial stem cells is considered. In addition, novel markers to identify endothelial stem cells, including CD157, EPCR, and CD31low VEGFR2low IL33+ Sox9+, are described.

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“…Apart from vascular remodelling via endothelial cells and smooth muscle cells, activation of WNT/β-catenin signalling has been implicated in the suppression of mesenchymal progenitor cells (MPC) differentiation into functional pericytes, thereby driving a phenotype of persistent microvascular dysfunction and abnormal angiogenesis (Gaskill et al 2017). Similarly, Summers et al suggested activation of WNT/β-catenin signalling in MPC induced emphysema-like distal lung remodelling and exacerbated vascular injury (Summers et al 2020).…”

Section: Pulmonary Vascular Diseasesmentioning

confidence: 99%

WNT Signalling in Lung Physiology and Pathology

Ciminieri

et al. 2021

Pharmacology of the WNT Signaling System

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Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 17 publications

References 111 publications

Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension

Progenitor/Stem Cells in Vascular Remodeling during Pulmonary Arterial Hypertension

Current Concepts on Endothelial Stem Cells Definition, Location, and Markers

WNT Signalling in Lung Physiology and Pathology

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