Residual hematropoietic effect in mice exposed to ochratoxin a prior to irradiation

Hong, Hue Hua L.; Jameson, Chales W.; Boorman, Gary A.

doi:10.1016/0300-483x(88)90236-3

Cited by 10 publications

(6 citation statements)

References 21 publications

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“…Doses of 2.5 mg OTA/kg feed administered to pigs reduces the phagocytic activity of macrophages and the production of IL2 [176], confirming the findings of Lea et al [164] and Holmberg et al [177]. The same decreases have been observed previously in mice [129,178], turkeys [171] and broiler chickens [179,180]. The effects of OTA on humoral immunity depend on the route of administration and the species.…”

Section: Immunotoxicity and Myelotoxicitysupporting

confidence: 75%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

896

525

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Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food products. OTA is nephrotoxic and is suspected of being the main etiological agent responsible for human Balkan endemic nephropathy (BEN) and associated urinary tract tumours. Striking similarities between OTA-induced porcine nephropathy in pigs and BEN in humans are observed. International Agency for Research on Cancer (IARC) has classified OTA as a possible human carcinogen (group 2B). Currently, the mode of carcinogenic action by OTA is unknown. OTA is genotoxic following oxidative metabolism. This activity is thought to play a central role in OTA-mediated carcinogenesis and may be divided into direct (covalent DNA adduction) and indirect (oxidative DNA damage) mechanisms of action. Evidence for a direct mode of genotoxicity has been derived from the sensitive 32P-postlabelling assay. OTA facilitates guanine-specific DNA adducts in vitro and in rat and pig kidney orally dosed, one adduct comigrates with a synthetic carbon (C)-bonded C8-dG OTA adduct standard. In this paper, our current understanding of OTA toxicity and carcinogenicity are reviewed. The available evidence suggests that OTA is a genotoxic carcinogen by induction of oxidative DNA lesions coupled with direct DNA adducts via quinone formation. This mechanism of action should be used to establish acceptable intake levels of OTA from human food sources.

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Section: Immunotoxicity and Myelotoxicitysupporting

confidence: 75%

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Pfohl‐Leszkowicz¹,

Manderville²

2006

Molecular Nutrition Food Res

896

525

View full text Add to dashboard Cite

show abstract

“…Doses of 2.5 mg OTA kg 1 feed administered to pigs reduces the phagocytic activity of macrophages and production of IL-2 (Harvey et al 1992), con®rming the ®ndings of Lea et al (1989) and Holmberg et al (1988). The same decreases have been observed previously in mice (Boorman et al 1984, Hong et al 1988, turkeys (Dwivedi and Burns 1985) and broiler chickens (Chang andHamilton 1980, Chang 1982). EOE ects of OTA on humoral immunity depend on the route of administration and the species.…”

Section: Immunotoxicity and Myelotoxicitysupporting

confidence: 87%

Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins

Pfohl‐Leszkowicz

Petkova-Bocharova²,

In³

et al. 2002

Food Additives and Contaminants

312

172

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A series of publications in the 1950s described a kidney disease in Bulgaria, the former Yugoslavia and Romania that became known as Balkan endemic nephropathy (BEN). The disease was qualified by World Health Organisation (WHO) experts as 'progressive and very gradually developing renal failure with insidious onset.... The last stage shows marked fibrosis...'. BEN is characterized by tubular degeneration, interstitial fibrosis and hyalinization of glomeruli accompanied by enzymuria and impaired renal function without nephrotic syndrome. Later, an association between BEN and tumours of the kidney pelvis and ureter was recognized, so that the problem of BEN became not only nephrological, but also oncological. There may also be an association with increased urinary bladder cancer incidence, although many confounding factors may interfere in the analysis of data for this organ. In view of the very intimate association between BEN and the urinary tract tumours (UTT), the term 'endemic uropathy' has been proposed. Several hypothesis concerning the aetiology of these diseases has been investigated, which include: predisposing genes factors, environmental factors (heavy metals, minerals, bacteria, leptospira, viruses, fungal toxins and, most recently, pliocene lignites). This paper reviews the different hypotheses about the aetiology of endemic uropathy and pays particular attention to the role of fungal toxins.

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“…It might have been that OTA decreased the synthesis of the immune globulins in the manner similar to aflatoxin. No matter which the exact mechanism was involved, it was obvious that the OTA was able to express the immunomodulatory effects earlier described by Hong et al (1988) and later confirmed by Singh et al (1990). Therefore, this also certainly confirms the dose-dependent effect of OTA on the changes of protein content in the serum of broilers.…”

Section: Resultssupporting

confidence: 76%

Blood serum protein status in broilers fed with increasing concentrations of ochratoxin A

Nedeljković-Trailović¹,

Trailovic²,

Dimitrijević³

et al. 2013

ACTA VET-BEOGRAD

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The 42-day long study was performed on a total number of 48 Hybro broilers divided into four groups. After the pre-experimental period of 14 days, 3 experimental groups of broilers (n=12) were formed and fed diets that contained 0.5, 1.0 and 1.5 mg/kg ochratoxin A (OTA) during the next seven consecutive days. In the same period, the control group of broilers was fed a diet with no toxin added. After the period of toxin addition, blood samples were taken from 6 animals in each group. The remaining animals (n=6) from the control and experimental groups were fed diets without OTA until the 42nd day of the study, when the blood samples were taken again. The total level of blood serum proteins was affected by treatment with different doses of OTA, but a significant and dose dependent increase of albumins together with a decrease of γ-globulin fraction was established. A/G ratio (Albumine/Globuline) suggested that the globulins were the dominant protein fraction in the blood serum samples obtained from all the broilers included in this study. The concentrations of α- and β- globulin in the serum were within physiological limits, but the concentration of γ-globulins significantly decreased. It can be concluded that the increasing dietary OTA levels (0.5, 1.0 and 1.5 mg/kg) had dose-dependent cumulative effect on blood serum proteins status in broilers, and the effect lasts even after the withdrawal of OTA from the feed

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Residual hematropoietic effect in mice exposed to ochratoxin a prior to irradiation

Cited by 10 publications

References 21 publications

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans

Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins

Blood serum protein status in broilers fed with increasing concentrations of ochratoxin A

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