Residue and intake risk assessment of prothioconazole and its metabolite prothioconazole-desthio in wheat field

Lin, Hongfang; Dong, Bizhang; Hu, Jiye

doi:10.1007/s10661-017-5943-1

Cited by 47 publications

(22 citation statements)

References 14 publications

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“…The following formulas are adopted to evaluate the long‐term dietary intake risk of pyraclostrobin or picoxystrobin: 17,18

NEDI = \sum ((), {STMR}_{i} \times F_{i}) / bw

{RQ}_{c} = NEDI / ADI \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

Dissipation, residues and risk assessment of pyraclostrobin and picoxystrobin in cucumber under field conditions

Zhao

2020

J Sci Food Agric

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BACKGROUND: Pyraclostrobin and picoxystrobin are two representative pesticides of strobilurins used to treat cucumber downy mildew, which have raised issues of food safety and human health. A new formulation containing these two compounds is being prepared for marketing in China. RESULTS: The dissipation and residual levels of pyraclostrobin and picoxystrobin in cucumbers under field conditions were determined simultaneously by a validated method via liquid chromatography-tandem mass spectrometry (LC-MS/MS). The dissipation rules were described by first-order kinetics and the half-lives of pyraclostrobin and picoxystrobin were less than 8.2 days and 3.4 days. The highest terminal residue of pyraclostrobin was 0.014 mg kg −1 which was lower than maximum residue limit (MRL) in China (0.5 mg kg −1) and of picoxystrobin was 0.029 mg kg −1 , respectively. In the long-term intake risk assessment of pyraclostrobin and picoxystrobin for general population (18-79 years), the chronic risk quotient (RQ c) varied from 5.64% to 21.97%. The assessment of short-term risks included children (1-6 years) and adults (18-79 years) and in which the RQ a values were 0.38% and 2.85%. Both results showed the intake risks of cucumber were acceptable. CONCLUSION: Pyraclostrobin and picoxystrobin degraded easily in cucumbers under open field conditions. The long-term and shortterm risks caused by final residues of pyraclostrobin and picoxystrobin were insignificant. The recommended pre-harvest interval of 3 days was safe. The article will be helpful in rational use of these pesticides and MRL formulation of picoxystrobin on cucumber.

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“…The following formulas are adopted to evaluate the long‐term dietary intake risk of pyraclostrobin or picoxystrobin: 17,18

NEDI = \sum ((), {STMR}_{i} \times F_{i}) / bw

{RQ}_{c} = NEDI / ADI \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

Dissipation, residues and risk assessment of pyraclostrobin and picoxystrobin in cucumber under field conditions

Zhao

2020

J Sci Food Agric

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“…Also, there still lacks an effective method that can determine the severity of diseased wheat ear groups. In addition, all the previous studies, evaluating the effects of fungicide applications on the control wheat FHB [35]- [36], employ a manual assessment method by counting the number of wheat ears affected to determine the efficacy of fungicide application programs [37]. Such traditional disease severity assessment method is laborious and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Efficacy of Fungicides for Control of Wheat Fusarium Head Blight Based on Digital Imaging

et al. 2020

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Fusarium head blight (FHB) is one of the most important diseases in wheat worldwide. Evaluation and identification of effective fungicides are essential for control of FHB. However, traditional methods based on the manual disease severity assessment to evaluate the efficacy of fungicides are timeconsuming and laborsome. In this study, we developed a new method to rapidly assess the severity of FHB and evaluate the efficacy of fungicide application programs. Enhanced red-green-green (RGG) images were processed from acquired raw red-green-blue (RGB) images of wheat ear samples; the images were transformed in color spaces through K-means clustering for rough segmentation of wheat ears; a random forest classifier was used with features of color, texture, geometry and vegetation index for fine segmentation of disease spots in wheat ears; a newly proposed width mutation counting algorithm was used to count wheat ears; and the disease severity of the wheat ears groups was graded and the efficacy of six fungicides was evaluated. The results show that the segmentation algorithm could segment wheat ears from a complex field background. And the counting algorithm could effectively solve the problem of wheat ear adhesion and occlusion. The average counting accuracy of all and diseased wheat ears were 93.00% and 92.64%, respectively, with the coefficients of determination (R 2) of 0.90 and 0.98, and the root mean square error (RMSE) of 10.56 and 7.52, respectively. The new method could accurately assess the diseased levels of wheat eat groups infected by FHB and determine the efficacy of the six fungicides evaluated. The results demonstrate a potential of using digital imaging technology to evaluate and identify effective fungicides for control of the FHB disease in wheat and other crop diseases. INDEX TERMS Fusarium head blight, K-means clustering, random forest, width mutation counting algorithm, pesticide spraying.

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“…It is one of the major prothioconazole metabolites 26 with higher activity 25 and greater toxicity 27 to rats. 26,[28][29][30] Although lots of previous studies showed that chiral triazole fungicides could be well separated by HPLC, 31,32 there are limited studies on the chiral resolution of prothioconazole or prothioconazole-desthio at normal and reverse phase conditions. 26,[28][29][30] Although lots of previous studies showed that chiral triazole fungicides could be well separated by HPLC, 31,32 there are limited studies on the chiral resolution of prothioconazole or prothioconazole-desthio at normal and reverse phase conditions.…”

Section: Introductionmentioning

confidence: 99%

“…24,25 Prothioconazole-desthio, (2RS)-2-(1-chlorocyclopropyl)-1-(2-chlorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol, is also a triazole compound in the enforced animal commodity residue definition (see Figure 1A). It is one of the major prothioconazole metabolites 26 with higher activity 25 and greater toxicity 27 to rats. Determination of prothioconazole and prothioconazole-desthio using HPLC and ultra performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) has been reported in animal food, soil, and wheat.…”

Section: Introductionmentioning

confidence: 99%

“…Determination of prothioconazole and prothioconazole-desthio using HPLC and ultra performance liquid chromatographytandem mass spectrometry (UPLC-MS/MS) has been reported in animal food, soil, and wheat. 26,[28][29][30] Although lots of previous studies showed that chiral triazole fungicides could be well separated by HPLC, 31,32 there are limited studies on the chiral resolution of prothioconazole or prothioconazole-desthio at normal and reverse phase conditions. 33 Simultaneous chiral separations of prothioconazole and prothioconazole-desthio to reduce analysis time and workload are urgently needed.…”

Section: Introductionmentioning

confidence: 99%

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Enantiomeric separation of prothioconazole and prothioconazole‐desthio on chiral stationary phases

Liu

Ding

2019

Chirality

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Prothioconazole is a type of broad-spectrum triazole thione fungicide developed by the Bayer Company. Prothioconazole-desthio is the main metabolite of prothioconazole in the environment. In our study, enantiomeric separation of prothioconazole and prothioconazole-desthio was performed on various chiral stationary phases (CSPs) by high-performance liquid chromatography (HPLC). It was found that polysaccharide CSPs showed better ability than brushing CSPs in enantiomeric separation. The successful chiral separation of prothioconazole could be achieved on self-made Chiralcel OD, commercialized Chiralcel OJ-H and Lux Cellulose-1. Chiralpak IA, Chiralpak IB, Chiralpak IC, Chiralcel OD, Chiralpak AY-H, Chiralpak AZ-H, and Lux Cellulose-1 realized the baseline separation of prothioconazole-desthio enantiomers. Simultaneous enantiomeric separation of prothioconazole and prothioconazole-desthio was performed on Lux Cellulose-1 using acetonitrile (ACN) and water as mobile phase. In most cases, low temperature favored the separation of two compounds. The influence of the mobile phase ratio or type was deeply discussed. We obtained larger Rs and longer analysis time with a smaller proportion of isopropanol (IPA) or ethanol and more water content at the same temperature. The ratio of ACN and water had influences on the outflow orders of prothioconazole-desthio enantiomers. This work provides a new approach for chiral separation of prothioconazole and prothioconazole-desthio with a discussion of chiral separation mechanism on different CSPs.

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Residue and intake risk assessment of prothioconazole and its metabolite prothioconazole-desthio in wheat field

Cited by 47 publications

References 14 publications

Dissipation, residues and risk assessment of pyraclostrobin and picoxystrobin in cucumber under field conditions

Dissipation, residues and risk assessment of pyraclostrobin and picoxystrobin in cucumber under field conditions

Evaluation of Efficacy of Fungicides for Control of Wheat Fusarium Head Blight Based on Digital Imaging

Enantiomeric separation of prothioconazole and prothioconazole‐desthio on chiral stationary phases

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