Resistance of native and circulating modified low-density lipoproteins in human blood to association

Abstract

The resistance of native and circulating modified low-density lipoproteins from human blood to spontaneous and polyethylene glycol-induced association was studied by recording light transmission fluctuations. Circulating modified low-density lipoproteins were less resistant to association than native low-density lipoproteins. Polyethylene glycol-induced association of low-density lipoproteins was irreversible. Our results suggest that atherogenic activity of circulating modified low-density lipoproteins is associated with their increased predisposition to irreversible association.

Circulating desialylated low density lipoprotein

“…This implies that it is possible to prevent atherogenesis by suppressing LDL association. Further investigation of the mechanisms of LDL association revealed the factors capable to promote or prevent the association [45][46][47][48][49][50]. It turned out that the most promising are poloxamers [50][51][52].…”