Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae

Radke, Myron G.; Sadun, E. H.

doi:10.1016/0014-4894(63)90063-8

Cited by 39 publications

(9 citation statements)

References 18 publications

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“…The dose of 3000 r appears to be quite suitable for vaccination purposes as the higher doses of radiation may cause over-attenuation of cercariae and consequently may not result in greater dissemination of the young juveniles in the liver tissue. The process of dissemination of juvenile flukes may cause better antigenic stimulation as has been suggested by several workers (Radke and Sadun, 1963;Lichtenberg and Sadun, 1963).…”

Section: Discussionmentioning

confidence: 82%

Histopathology of experimental Schistosoma incognitum infection in mice following exposure to normal and irradiated cercariae

Tewari

Ramachandran

1979

J. Helminthol.

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The tissue reactions in mice, experimentally infected with normal and irradiated cercariae of S. incognitum were studied. The lesions observed in the skin, liver, lungs and the intestine of mice infected with normal cercariae are briefly described, and compared with those observed with cercariae irradiated at 3000 r of gamma rays. In general, the reactions in mice exposed to normal cercariae were more intense than in those infected with irradiated cercariae. The severity of the reactions appeared largely due to the deposition of eggs in the tissues of the mice infected with normal cercariae. The experimental evidence suggested that most of the flukes from the irradiated cercariae are destroyed in the liver by tissue reaction.

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Section: Discussionmentioning

confidence: 82%

Histopathology of experimental Schistosoma incognitum infection in mice following exposure to normal and irradiated cercariae

Tewari

Ramachandran

1979

J. Helminthol.

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“…This rationale was soon incorporated into vaccine development, specifically for pathogens whose immunogenicity was destroyed by other means of inactivation. γ‐Irradiation was applied for the preparation of experimental vaccines against a number of infectious diseases, including parasitic ( Toxoplasma gondii , 88 Dictyocaulus viviparus , 89 Ancylostoma caninum , 90 Schistosoma japonicum , 91 , 92 Plasmodium berghei , 93 , 94 Trypanosoma congolense 95 and T. gondii ), 88 bacterial ( Escherichia coli , Pasteurella tularensis , 96 , 97 Mycobacterium tuberculosis 98 and Listeria monocytogenes ) 99 and viral diseases (bluetongue, 100 , 101 Venezuelan equine encephalitis, 102 , 103 rabies, 104 smallpox, 105 , 106 mumps 107 and influenza) 108 . Among these studies that have directly compared γ‐irradiation with other forms of inactivation methods, the superior retention of immunogenicity by γ‐irradiation has been consistently observed 104 , 109 , 110 , 111 …”

Section: γ‐Ray Sterilization As a Superior Inactivation Methods For Inmentioning

confidence: 99%

Return of inactivated whole‐virus vaccine for superior efficacy

Furuya

2011

Immunol Cell Biol

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The swine, influenza, H1N1 outbreak in 2009 highlighted the inadequacy of the currently used antibody‐based vaccine strategies as a preventive measure for combating influenza pandemics. The ultimate goal for successful control of newly arising influenza outbreaks is to design a single‐shot vaccine that will provide long‐lasting immunity against all strains of influenza A virus. A large amount of data from animal studies has indicated that the cross‐reactive cytotoxic T (Tc) cell response against conserved influenza virus epitopes may be the key immune response needed for a universal influenza vaccine. However, decades of research have shown that the development of safe T‐cell‐based vaccines for influenza is not an easy task. Here, I discuss the overlooked but potentially highly advantageous inactivation method, namely, γ‐ray irradiation, as a mean to reach the Holy Grail of influenza vaccinology.

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“…In helminths, irradiated vac-in survival time afforded by killed T , gondii was cines have been used to protect against cestodes only marginally better than the use of Freund's (20), nematodes (10,13,14,21), and trematodes complete adjuvant alone (12). Immunity against (9,16,22). In protozoa they have been used toxoplasmosis, as in all intracellular infections, against malaria (2,3,15,24) and trypanosomes is chiefly of the cellular type.…”

Section: Experiments IVmentioning

confidence: 99%

“…These include prevention of the disease, diagnosis of the disease te of toxoplasmosis, and therapy, especially Useful recommendations have ding ways t o minimize the posacquiring this infection (7). However, of the widespread presence of Toxoondii in animals that humans consume le widespread presence of the from cats, a safe vaccine might e to manage certain patients such as n-immune women wishing to bear children a high-risk area and immunosuppressive Several reports have appeared concerning the 'Received Decem ber 16,1974.…”

Section: Introductionmentioning

confidence: 99%

The use of irradiated vaccine in immunization against experimental murine toxoplasmosis

Seah¹,

Hucal²

1975

Can. J. Microbiol.

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Trophozoites from the peritoneal cavities of mice infected with the RH strain Toxoplasma gondii were given irradiation in doses of 5, 10, 15, and 20 kiloroentgens (kr). CD-1 strain mice that received intraperitoneal inoculation of trophozoites irradiated with 5 kr all died of toxoplasmosis, but the mice that received trophozoites irradiated with the higher doses all survived. The survirors that were examined were found to be free of toxoplasmic cysts. Single doses of these irradiated vaccines provided good protection to subsequent virulent challenge. This protection was 100% in the first 3 weeks after the immunization. Survivors of the first challenge were also solidly protected against a subsequent rechallenge.

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Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae

Cited by 39 publications

References 18 publications

Histopathology of experimental Schistosoma incognitum infection in mice following exposure to normal and irradiated cercariae

Histopathology of experimental Schistosoma incognitum infection in mice following exposure to normal and irradiated cercariae

Return of inactivated whole‐virus vaccine for superior efficacy

The use of irradiated vaccine in immunization against experimental murine toxoplasmosis

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