Resistance to macrocyclic lactone anthelmintics by<i>Haemonchus contortus</i>and<i>Ostertagia circumcincta</i>in sheep in New Zealand

Vickers, Mary; Yenning, M; McKenna, P.B.; Mariadass, B

doi:10.1080/00480169.2001.36211

Cited by 36 publications

(18 citation statements)

References 25 publications

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“…As can be seen in Table 2, this anthelmintic showed the highest effectiveness rate (stand-alone) in five studies involving sheep (CUNHA et al, 1998;THOMAZ-SOCCOL et al, 2004;CEZAR et al, 2010;LIMA et al, 2010b;SCZESNY-MORAES et al, 2010) and in three studies involving goats (AHID et al, 2007; RODRIGUES et al, 2007; LIMA et al, 2010b). Although its mechanism of action is similar to that of ivermectin, several authors around the world have observed the greater effectiveness of moxidectin in strains resistant to ivermectin (BARNES et al, 2001;VICKERS et al, 2001;LLOBERAS et al, 2013). Prichard et al (2012) ascribed the difference in the effectiveness of these two antiparasitics to different interactions in glutamate-gated ion channels where they act, and to different levels of expression of ABC proteins.…”

Section: Developments In Research and The Effectiveness Of Anthelmintmentioning

confidence: 99%

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Salgado

Santos

2016

Rev. Bras. Parasitol. Vet.

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Frequent and inappropriate use of all classes of antiparasitic drugs in small ruminants has led to failures in their effectiveness, culminating in a global problem of anthelmintic resistance. Brazil stands out as one of the world's leaders in publications about anthelmintic resistance, and for having the most numerous reports of this resistance in small ruminants in the Americas. These studies have involved mainly the fecal egg count reduction test (FECRT) and its correlation with field management practices. In vivo effectiveness testing is conducted in areas where livestock is of greater economic significance, e.g., in the South (sheep) and Northeast (goats), or is important for research and economic centers, such as the Southeast (sheep). The most widely studied species is sheep, for which the widest range of drugs is also evaluated. Despite significant advances achieved in molecular research, laboratory analyses should include knowledge about the reality in the field so that they can become feasible for the producer. Moreover, molecular studies can be underpinned by the analysis of field studies, such as the maintenance of antiparasitic effectiveness over time and the mechanisms involved in this process.Keywords: Small ruminants, anthelmintic resistance, sheep, goat, gastrointestinal nematodes. ResumoO uso frequente e inapropriado de todas as classes de antiparasitários em pequenos ruminantes levou a falhas de eficácia, culminando na problemática global de resistência anti-helmíntica. O Brasil destaca-se como sendo um dos pioneiros nas publicações com resistência anti-helmíntica no mundo e por ter o maior número de relatos em pequenos ruminantes na América. Essas pesquisas envolvem principalmente o teste da redução da contagem de ovos nas fezes (TRCOF) e sua correlação com as práticas de manejo utilizadas no campo. Os estudos de testes de eficácia in vivo localizam-se em áreas onde há maior importância dos rebanhos como nas Regiões Sul (ovinos) e Nordeste (caprinos), ou com importância em polos de pesquisa e econômicos, como a região Sudeste (ovinos). Ovina é a espécie mais estudada e com maior gama de drogas avaliadas. Mesmo com grande avanço em pesquisas moleculares, as análises laboratoriais devem envolver o conhecimento da realidade do campo para que possam se tornar viáveis ao produtor. Além disso, a análise dos estudos de campo pode nortear estudos moleculares como, por exemplo, a manutenção da eficácia das drogas ao longo dos anos e os mecanismos envolvidos em tal processo.

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Section: Developments In Research and The Effectiveness Of Anthelmintmentioning

confidence: 99%

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Salgado

Santos

2016

Rev. Bras. Parasitol. Vet.

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“…In New Zealand, parasitism has traditionally been controlled using anthelmintics, but anthelmintic resistance in endoparasites of sheep has become increasingly common (Vickers et al 2001). In addition, there is increasing consumer concern regarding chemical residues in meat and the effect of anthelmintics on the environment (Wall & Strong 1987).…”

Section: Introductionmentioning

confidence: 99%

Forward creep grazing of lambs to increase liveweight gain and post‐weaning resistance to endoparasites

Moss

Dynes

Goulter

et al. 2009

New Zealand Journal of Agricultural Research

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An experiment was conducted in New Zealand to assess the effect of creep grazing of lambs on their liveweight and resistance to endoparasites. Comparisons included creep versus non-creep grazing at two herbage allowances and regular anthelmintic drenching. Treatments commenced with 6-week-old twin reared lambs, and ceased when they were weaned at 13 weeks, with the exception of the drench treatment which continued post-weaning. Pastures used contained sheep endoparasites. At 8 weeks post-weaning one lamb from each twin set was slaughtered, remaining lambs were then drenched, and 8 and 9 days later were orally dosed with 180 Trichostrongylus colubriformis L 3 /kg liveweight each day (averaging 12 650/lamb). Three weeks later these lambs were also slaughtered. Measurements included liveweight, faecal worm egg count (FEC) and adult endoparasite numbers. Neither herbage allowance nor creep grazing affected FEC or adult endoparasite numbers. Fortnightly drenching of creep grazed lambs on the high allowance had no effect on weaning liveweight, but it improved liveweights post-weaning. Neither creep grazing, preweaning herbage allowance, nor drenching, affected lamb resistance to endoparasites. Creep grazing and the higher allowance both increased weaning A09026; liveweights. The response to creep grazing was highest at the lower allowance, increasing weaning liveweights by 4 kg. Pre-weaning treatment had no effect on post-weaning growth rate.

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“…In 2000, the fi rst cases of resistance to the ML class of compounds were reported from sheep fl ocks in New Zealand (Leathwick et al 2000;Mason et al 2001;Hughes and McKenna 2005); populations of Ostertagia circumcincta showed resistance to ivermectin. Soon after, ML resistance in both O. circumcincta and H. contortus on the same farm was reported (Vickers et al 2001).…”

Section: Introductionmentioning

confidence: 91%

Prevalence of anthelmintic resistance on sheep farms in New Zealand

Waghorn

Leathwick

Rhodes³

et al. 2006

New Zealand Veterinary Journal

125

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Anthelmintic resistance in parasitic nematodes of sheep is common in New Zealand. Not only was resistance to albendazole and levamisole common, but resistance to the ML, ivermectin, was at a higher prevalence than expected. Sheep farmers and advisors in New Zealand need to re-evaluate the way they manage parasites, and more research is urgently needed if the steady decline in anthelmintic susceptibility is to be halted.

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Resistance to macrocyclic lactone anthelmintics byHaemonchus contortusandOstertagia circumcinctain sheep in New Zealand

Cited by 36 publications

References 25 publications

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Overview of anthelmintic resistance of gastrointestinal nematodes of small ruminants in Brazil

Forward creep grazing of lambs to increase liveweight gain and post‐weaning resistance to endoparasites

Prevalence of anthelmintic resistance on sheep farms in New Zealand

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