Resistance to Thyroid Hormone with Missense Mutation (V349M) in the Thyroid Hormone Receptor Beta Gene

Abstract

2Resistance to thyroid hormone (RTH) is a syndrome characterized by reduced sensitivity to the thyroid hormone. It is generally caused by mutations in the thyroid hormone receptor β (TRβ) gene. On the basis of its clinical features, two different forms of this syndrome have been described: generalized resistance and pituitary resistance. A total of 122 TRβ gene mutations have been identified thus far. A 38-year-old woman presented with intermittent palpitation. Thyroid function tests revealed elevated levels of free T4 and TSH. TSH α-subunit levels were 0.41 mIU/mL, and magnetic resonance images of the sellar region evidenced no abnormal findings. The TSH response to TRH stimulation was found to be normal. The sequence analysis of the TRβ gene verified a missense mutation in exon 11, and the observed amino acid alteration was a substitution of a valine for a methionine at codon 349. We report the first case of a woman with RTH, which was found to be caused by a missense mutation (V349M) in the TRβ gene.

A Case of Resistance to Thyroid Hormone with Thyroid Cancer

“…The clinical presentation is variable, but common features include goiter, an absence of the classic thyrotoxic symptoms and metabolic consequences of elevated thyroid hormone levels, and a normal or exaggerated thyroid stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH). Until now over 1,000 cases have been identified around the world, and nine cases have been reported in Korea ( 2 - 9 ).…”