Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease

Souza, Michel Kendy; Neves, Rodrigo Vanerson Passos; Rosa, Thiago Santos; Cenedeze, Marcos Antônio; Arias, Simone Costa Alarcon; Fujihara, Clarice Kazue; Bacurau, Reury Frank Pereira; Câmara, Niels Olsen Saraiva; Filho, Álvaro Pacheco e Silva

doi:10.1016/j.lfs.2018.05.034

Cited by 28 publications

(13 citation statements)

References 23 publications

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“…Reactive oxygen species also increase the production of antioxidants that stimulate the release of antiinflammatory cytokines, decrease pro-inflammatory cytokines (Nezu & Suzuki, 2020) and modify the redox balance (e.g., MPO/PON1 ratio), which probably explains our results. In support, our group previously reported that RT attenuated inflammation among CKD patients (Souza et al, 2018), and this effect might induce changes in MPO and PON1 levels (Hachiya et al, 2000;Ndrepepa, 2019;Tisato et al, 2019).…”

Section: Discussionsupporting

confidence: 79%

Improving the prognosis of renal patients: The effects of blood flow‐restricted resistance training on redox balance and cardiac autonomic function

Deus

Neves

Corrêa

et al. 2021

Experimental Physiology

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Patients with chronic kidney disease (CKD) are prone to cardiovascular diseases secondary to abnormalities in both autonomic cardiac function and redox balance [myeloperoxidase (MPO) to paraoxonase 1 (PON1) ratio]. Although aerobic training improves both autonomic balance and redox balance in patients with CKD, the cardioprotective effects of resistance training (RT), with and without blood flow restriction (BFR), remain unknown. We aimed to compare the effects of RT and RT+BFR on antioxidant defence (PON1), pro-oxidative status (MPO), cardiac autonomic function (quantified by heart rate variability analysis) and renal function. Conservative CKD (stages 1 to 5 who do not need hemodialysis) patients (n = 105, 33 female) of both sexes were randomized into three groups: control (CTL; 57.6 ± 5.2 years; body mass index, 33.23 ± 1.62 kg/m 2), RT (58.09 ± 6.26 years; body mass index 33.63 ± 2.05 kg/m 2) and RT+BFR (58.06 ± 6.47 years; body mass index, 33.32 ± 1.87 kg/m 2). Patients completed 6 months of RT or RT+BFR on three non-consecutive days per week under the supervision of strength and conditioning professionals. Training loads were adjusted every 2 months. Heart rate variability was recorded with a Polar-RS800 and data were analysed for time and frequency domains using Kubios software. The redox balance markers were PON1 and MPO, which were analysed in plasma samples. Renal function was estimated as estimated glomerular filtration rate. The RT and RT+BFR decreased pro-oxidative MPO (RT, ∼34 ng/ml and RT+BFR, ∼27 ng/ml),

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Section: Discussionsupporting

confidence: 79%

Improving the prognosis of renal patients: The effects of blood flow‐restricted resistance training on redox balance and cardiac autonomic function

Deus

Neves

Corrêa

et al. 2021

Experimental Physiology

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“…In some clinical conditions, such as obesity, diabetes, hypertension, endothelial dysfunction and chronic kidney disease, DRT and IRT were found to be satisfactory to improve glycemic control, reduce oxidative stress, and inflammation (Figard et al, 2006; Panveloski-Costa et al, 2011; Kruger et al, 2013; Talebi-Garakani and Safarzade, 2013; Neves et al, 2016; Souza M.K. et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The only exception was that the animals of this group performed the exercise in isometry as described in the MIR test. Initially, a pilot study imposing loads from 5 to 70% of MWC indicated that 30% was the maximum overload the rats could isometrically sustain for more than 60 s. Coincidentally, is the same load applied in studies with humans on hemodynamic outcomes (Millar et al, 2014; Souza M.K. et al, 2018).…”

Section: Methodsmentioning

confidence: 99%

Dynamic, Not Isometric Resistance Training Improves Muscle Inflammation, Oxidative Stress and Hypertrophy in Rats

et al. 2019

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This study aimed to compare the effects of dynamic (DRT) and isometric (IRT) resistance training on blood glucose, muscle redox capacity, inflammatory state, and muscle strength and hypertrophy. Fifteen 12-week-old male Wistar rats were randomly allocated into three groups: control group (CTL), DRT, and IRT, n = 5 animals per group. The animals were submitted to a maximal weight carried (MWC; every 15 days) and maximum isometric resistance (MIR; pre- and post-training) tests. Both training protocols were performed five times a week during 12 weeks, consisting of one set of eight uninterrupted climbs for 1 min with a 30% overload of MWC. The animals in the IRT group remained under isometry for 1 min. The DRT group experienced greater MWC from pre- to post-training compared to the CTL and IRT groups (p < 0.0001). The DRT and IRT groups displayed similar gains in MIR (p = 0.3658). The DRT group exhibited improved glycemic homeostasis (p = 0.0111), redox (p < 0.0001), and inflammatory (p < 0.0001) balance as compared with CTL and IRT groups. In addition, the improved glycemic profile was associated with an increase in muscle strength and hypertrophy, improvement in redox balance and inflammation status. We conclude that DRT was more effective than IRT on increasing cross-sectional area, but not muscle strength, in parallel to improved blood glucose, inflammatory status, and redox balance.

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“…Calorie restriction (CR) and physical exercise can reduce cellular senescence and prolong healthy lifespan (Cartee et al, 2016;Souza et al, 2018). A study on weight loss due to CR relieves cell senescence in white adipose tissue (List et al, 2016).…”

Section: Calorie Restrictionmentioning

confidence: 99%

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Zhou

Liu

2020

Front. Pharmacol.

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Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a state of accelerated and premature aging. Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. In this review, we discuss current understanding of the role and mechanism of cellular senescence in kidney fibrosis. We also highlight potential options of targeting senescent cells for the treatment of CKD.

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Resistance training attenuates inflammation and the progression of renal fibrosis in chronic renal disease

Cited by 28 publications

References 23 publications

Improving the prognosis of renal patients: The effects of blood flow‐restricted resistance training on redox balance and cardiac autonomic function

Improving the prognosis of renal patients: The effects of blood flow‐restricted resistance training on redox balance and cardiac autonomic function

Dynamic, Not Isometric Resistance Training Improves Muscle Inflammation, Oxidative Stress and Hypertrophy in Rats

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

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