Resistance training improves the lipid profile, combat oxidative stress and inhibit MMP-2 activity in the left ventricle diet-induced obese rats

Abstract

The purpose of the present study was to evaluate the effects of the resistance training (RT) on the lipid profile and metabolism, oxidative stress, and activity of metalloproteinase-2 (MMP-2) in the left ventricle (LV) of dietinduced obesity rats. Methods: Forty males Wistar rats 90 days-old were grouped into four groups (n=10): i) Sedentary group (SED); ii) Obese sedentary group, feed with high-fat diet (Ob-SED); iii) Resistance Trained group (RT), and iv) Obese Resistance trained group (Ob-RT). The LV was assayed to Obesity index, LV lipid content, citrate synthase activity, lipid peroxidation (TBARS), enzymatic and non-enzymatic antioxidant systems, lipid profile, cardio-metabolic parameters, and activity of MMP-2. Results: High-fat diet was associated with manifestations of the obesity, body mass gain, and increased obesity index, accompanied by an alteration in the lipid profile. On the other hand, RT was able to prevent body weight gain, to reduce the obesity index and to improve the lipid profile, to elevate the activation of the citrate synthase, and to decrease MMP-2 activity in the LV of obese rats. Conclusion: RT positively modulated blood lipid profile and antioxidant enzymes preventing the increased activity of MMP-2 in the left ventricle from rats fed with high-fat diet.

High-Intensity Interval Training Does Not Change Vaspin and Omentin and Does Not Reduce Visceral Adipose Tissue in Obese Rats

“…We also highlight that, although there were no differences between most cytokines, there was an increase in vaspin in obese animals, which has been used as a biomarker of adiposity, and a reduction of adiponectin in HFD animals. These data together show the effective induction of obesity, supporting the studies already described in the literature (Estadella et al, 2004;Duarte et al, 2008;Sene-Fiorese et al, 2008;Speretta et al, 2012Speretta et al, , 2016Suk and Shin, 2016;Diogo et al, 2020). In addition, the diet promoted a decrease in the food intake of these animals.…”

O Treinamento Resistido Atenua a Remodelação Cardíaca Induzida por uma Dieta Hiperlipídica em Roedores: Uma Revisão Sistemática

“…Em relação às características dos animais ( Tabela 3 ), a maioria dos estudos (n = 4; 80%) utilizou ratos Wistar 28 - 30 e Sprague-Dawley, 30 enquanto apenas um artigo utilizou camundongos Swiss. 31 Todos os estudos foram realizados com animais machos, e a idade inicial dos animais variou entre 21 e 90 dias.…”

“… 31 Todos os estudos foram realizados com animais machos, e a idade inicial dos animais variou entre 21 e 90 dias. 28 , 29 , 31 , 32 Apenas os animais do estudo de Kim et al 33 eram mais velhos que os demais (51 semanas).…”

“…Em todos os estudos, os animais receberam uma DH por um período anterior ao início do TR, que variou entre 3 e 18 semanas. 28 , 29 , 31 - 33 Subsequentemente, a DH foi mantida durante o período de TR até o final do experimento, que durou 8, 28 , 32 10, 33 e 12 semanas. 29 , 33 …”

“…Em 3 estudos (60%), antes do início do TR, os animais foram submetidos ao teste de carga máxima (TCM) para determinação da carga utilizada nas sessões de TR. Nestes estudos, o TCM consistiu em subir escadas com carga equivalente a 50% 32 e 75% 28 , 29 da MC. Nas subidas subsequentes foram acrescentadas cargas de 30 g até o animal atingir a fadiga muscular.…”