Resistant Starch Attenuates Bone Loss in Ovariectomised Mice by Regulating the Intestinal Microbiota and Bone-Marrow Inflammation

Tousen, Yuko; Mu, Yu; Nagahata, Yuya; Kobayashi, Isao; Inoue, Masahiro; Ishimi, Yoshiko

doi:10.3390/nu11020297

Cited by 43 publications

(40 citation statements)

References 37 publications

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“…Mice were used in 23 studies including C57BL6 in 15 studies, 33 - 47 CB6F1 in one study, 48 BALB/c in three studies, 39 , 48 , 49 Swiss Webster in one study, 17 ddY in one study, 50 senescence-accelerated mouse prone 6 (SAMP6) and senescence-accelerated mouse resistant 1 (SAMR1) in two studies, 51 , 52 and Institute of Cancer Research (ICR) mice in two studies. 53 , 54 Germ-free mice were used in six studies 33 , 34 , 36 , 38 , 45 , 48 and rats were used in six studies, including four Sprague-Dawley 55 - 58 and two Wistar.…”

Section: Resultsmentioning

confidence: 99%

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The role of gut microbiota in bone homeostasis

Liu

et al. 2021

Bone & Joint Research

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Aims The effect of the gut microbiota (GM) and its metabolite on bone health is termed the gut-bone axis. Multiple studies have elucidated the mechanisms but findings vary greatly. A systematic review was performed to analyze current animal models and explore the effect of GM on bone. Methods Literature search was performed on PubMed and Embase databases. Information on the types and strains of animals, induction of osteoporosis, intervention strategies, determination of GM, assessment on bone mineral density (BMD) and bone quality, and key findings were extracted. Results A total of 30 studies were included, of which six studies used rats and 24 studies used mice. Osteoporosis or bone loss was induced in 14 studies. Interventions included ten with probiotics, three with prebiotics, nine with antibiotics, two with short-chain fatty acid (SCFA), six with vitamins and proteins, two with traditional Chinese medicine (TCM), and one with neuropeptide Y1R antagonist. In general, probiotics, prebiotics, nutritional interventions, and TCM were found to reverse the GM dysbiosis and rescue bone loss. Conclusion Despite the positive therapeutic effect of probiotics, prebiotics, and nutritional or pharmaceutical interventions on osteoporosis, there is still a critical knowledge gap regarding the role of GM in rescuing bone loss and its related pathways. Cite this article: Bone Joint Res 2021;10(1):51–59.

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Section: Resultsmentioning

confidence: 99%

“…Ovariectomy was performed on mice in three studies, 44 , 49 , 50 and rats in five studies. 55 - 58 , 62 Other methods included high-fat diet (HFD), 60 tenofovir disoproxil fumarate (TDF), 40 and glucocorticoid (GC) in two studies.…”

Section: Resultsmentioning

confidence: 99%

The role of gut microbiota in bone homeostasis

Liu

et al. 2021

Bone & Joint Research

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“…IL-7 primarily acts on macrophages, lymphoid B cells, and lymphoid T cells and plays an essential role in cell survival, proliferation, and differentiation [30]. IL-7/IL-7 receptor enhances bone resorption by activating T cells and T celldependent osteoclastogenesis [31]. IL-33 is a member of the IL-1 family and functions as an important bone-protecting cytokine.…”

Section: Discussionmentioning

confidence: 99%

The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast

Zhang

Meng

et al. 2020

BioMed Research International

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Yishen Bugu Ye (YSBGY), a traditional Chinese medicine comprising 12 types of medicinal herbs, is often prescribed in China to increase bone strength. In this study, the antiosteoporotic effects of YSBGY were investigated in C57BL/6 mice afflicted with dexamethasone-(Dex-) induced osteoporosis (OP). The results showed that YSBGY reduced the interstitial edema in the liver and kidney of mice with Dex-induced OP. It also increased the number of trabecular bone elements and chondrocytes in the femur, promoted cortical bone thickness and trabecular bone density, and modulated the OP-related indexes in the femur and tibia of OP mice. It also increased the serum concentrations of type I collagen, osteocalcin, osteopontin, bone morphogenetic protein-2, bone morphogenetic protein receptor type 2, C-terminal telopeptide of type I collagen, and runt-related transcription factor-2 and reduced those of tartrate-resistant acid phosphatase 5 and nuclear factor of activated T cells in these mice, suggesting that it improved osteoblast differentiation and suppressed osteoclast differentiation. The anti-inflammatory effect of YSBGY was confirmed by the increase in the serum concentrations of interleukin-(IL-) 33 and the decrease in concentrations of IL-1, IL-7, and tumor necrosis factor-α in OP mice. Furthermore, YSBGY enhanced the serum concentrations of superoxide dismutase and catalase in these mice, indicating that it also exerted antioxidative effects. This is the first study to confirm the antiosteoporotic effects of YSBGY in mice with Dex-induced OP, and it showed that these effects may be related to the YSBGYinduced modulation of the osteoblast/osteoclast balance and serum concentrations of inflammatory factors. These results provide experimental evidence supporting the use of YSBGY for supporting bone formation in the clinical setting.

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“…The authors provided insight into how microbiota metabolites, SCFAs, regulate Th1 cell functions to maintain intestinal homeostasis. The intestinal microbiota may regulate bone metabolism by reducing levels of proinflammatory cytokines, and T cells in bone tissues of estrogendeficient mice have been reported by Touse et al [5] . Ovariectomised (OVX) mice fed a 20% acid-hydrolyzed high amylose (AH) corn head, and was inability to walk.…”

Section: Introductionmentioning

confidence: 86%