Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women

Kumar, Sandeep; Gupta, Vishal; Srivastava, Nidhi; Gupta, Vandana; Mishra, Sameeksha; Mishra, Supriya; Shankar, Madhav Natu; Roy, Uma; Chandra, Abhijit; Negi, M.P.S.

doi:10.1016/j.imlet.2014.07.009

Cited by 28 publications

(23 citation statements)

References 40 publications

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“…SNPs are found in the RETN promoter and 3'-untranslated regions [14]. Genetic variation at the RETN locus carries a risk of several diseases, including the metabolic syndrome and colon cancer [15,16] and those with a functional RETN gene polymorphism at -420 (rs1862513) are at risk of developing type 2 diabetes [17,18], and associated with obesity in Tunisian population [19]. RETN SNPs have been found to correlated with worsening disease in Chinese Han patients with lung cancer [20].…”

Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer. Compared with wild-type (GG) carriers, those carrying the AG genotype of the RETN SNP rs3219175 and those carrying at least one A allele in the SNP rs3219175 had a higher chance of developing breast cancer (adjusted odds ratio, AOR: 1.295, 95% confidence intervals, CI: 1.065-1.575 and 2.202, 1.701-2.243, respectively). When clinical aspects and the RETN SNP rs7408174 were examined in the breast cancer cohort, the CT genotype was linked to late-stage disease, while women with luminal A disease and at least one C allele were likely to progress to stage III/IV disease and to develop highly pathological grade III disease. Moreover, resistin-positive individuals were at greater risk than resistin-negative individuals for developing pathological grade III disease (OR: 5.020; 95% CI: 1.380-18.259). This study details risk associations between resistin and RETN SNPs in breast cancer susceptibility in Chinese Han women.

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Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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“…Several studies have shown that variants of the resistin gene and their imbalance have an impact on metabolic parameters and cardiovascular risk [ 64 , 65 ]. Subjects with 420C/G allele showed increases in resistin plasma concentrations [ 66 , 67 ], elevated glucose levels at birth [ 68 ], high HbA1c levels [ 69 ], and increased risk of T2DM [ 65 ]. At the same time, they also had increased levels of triglycerides and higher prevalence of MetS and obesity [ 61 ].…”

Section: Adipokines As Biomarkers In Atherosclerotic Heart Diseasementioning

confidence: 99%

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

2018

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Cardiovascular disease is the leading cause of death among both women and men, but there is still a great percentage of misdiagnosis and lack of clearly defined criteria. Advances in biomolecular science have proven the crucial role of inflammation and, more importantly, the role of adipokines in mediating all stages of coronary artery disease. It has also been suggested that regional fat deposits, more precisely from thoracic region, have a major influence on the development of coronary artery disease by creating a local proatherogenic environment. The immune system closely interacts with metabolic risk factors to initiate, promote, and further aggravate the atherosclerotic lesions on the arterial wall all with the “help” of adipokines. So nowadays, research extensively focuses on uncovering biomarkers that would provide an increased chance of detecting subclinical cardiac distress and also add a consistent value to current guideline-imposed risk criteria.

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“…Many studies have shown significant association between single nucleotide polymorphism RETN and determinants of metabolic syndrome and resistin levels (Azuma et al 2004;Cho et al 2004;Hivert et al 2009;Norata et al 2007;Kumar et al 2014). Several studies reported that the polymorphisms in the promoter region of RETN including rs1862513 (-420C[G) and rs3219175 have potential functional role for determining circulating resistin levels by altering the transcriptional activity and elevating resistin messenger ribonucleic acid levels in abdominal fat (Osawa et al 2004;Onuma et al 2010;Cho et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of the Resistin Gene and Their Association with Obesity and Resistin Levels in Malaysian Malays

et al. 2015

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Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine association between resistin levels with certain SNPs and haplotypes of RETN. A total of 631 Malaysian Malay subjects were included in this study and genotyping was carried out using Sequenom MassARRAY. There was no significant difference found in both allelic and genotype frequencies of each of the RETN SNPs between the obese and non-obese groups after Bonferroni correction. RETN rs34861192 and rs3219175 SNPs were significantly associated with log-resistin levels. The GG genotype carriers are found to have higher levels of log-resistin compared to A allele carriers. The RETN haplotypes (CAG, CGA and GA) were significantly associated with resistin levels. However, the haplotypes of the RETN gene were not associated with obesity. Resistin levels were not correlated to metabolic parameters such as body weight, waist circumference, body mass index, and lipid parameters. RETN SNPs and haplotypes are of apparent functional importance in the regulation of resistin levels but are not correlated with obesity and related markers.

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Resistin 420C/G gene polymorphism on circulating resistin, metabolic risk factors and insulin resistance in adult women

Cited by 28 publications

References 40 publications

Impacts of RETN genetic polymorphism on breast cancer development

Impacts of RETN genetic polymorphism on breast cancer development

Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction

Polymorphisms of the Resistin Gene and Their Association with Obesity and Resistin Levels in Malaysian Malays

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