Resistin as a risk factor for all-cause (and cardiovascular) death in the general population

Abstract

Serum resistin is a pro-inflammatory cytokine that has been described as a risk factor associated with mortality in several clinical sets including type 2 diabetes. Mortality studies in the general population are needed to find out the risk of death associated to this cytokine. In a follow-up study of a cohort of adult population (n = 6636) in Spain over a period of fifteen years (447 deaths/102,255 person-years), serum resistin measurements and death records were obtained. The risks of all-cause deaths, and deaths from cardiovascular and oncological diseases were estimated. Hazard ratios (HR) and its confidence intervals (CI) were calculated using multivariable Cox models, adjusting the effect of 11 traditional risk factors. The risk of all-cause mortality among participants exposed to the highest quintile of resistin was always higher than among those in the lowest quintile (HR varied between 1.55 when smoking was the adjusted factor [95% CI 1.17–2.05], and 1.68 when the adjusted factor was physical activity [95% CI 1.27–2.21]). The maximally adjusted model, accounting for the effect of all traditional factors, corroborated this higher risk of all-cause mortality among people in the highest resistin quintile (HR = 1.52; 95% CI 1.13–2.05). The effect of resistin was even higher for cardiovascular deaths (HR = 2.14; 95% CI 1.13–4.06), being exceeded only by suffering diabetes (HR = 3.04; 95% CI 1.98–4.69) or previous acute coronary syndrome (HR = 3.67; 95% CI 2.18–6.18). This findings corroborate the role of resistin as a risk factor for all-cause (and cardiovascular) death in the general population.

Acute effects of moderate-intensity constant training on circulatory fibroblast growth factor 21, resis-tin, and adiponectin of physically inactive young adults

“…Resistin has gained scientific interest in the last years given that it has been described as marker for cardiovascular death. For instance, after assessing more than 6600 adults and following them for 15 years, it was reported that participants with the higher quintile of circulatory resistin had higher risk of all-cause mortality, and an even higher risk of cardiovascular deaths (Del Cristo Rodriguez Perez et al, 2022). This is associated with the pro-inflammatory and insulin-resistant function of this protein (Rachwalik et al, 2021), therefore, strategies such as exercise has been assessed to see if they are able to modify this outcome.…”