Resistin Contribution to Cardiovascular Risk in Chronic Kidney Disease Male Patients

Abstract

Background: Resistin is a molecule that belongs to the Resistin-Like Molecules family (RELMs), the group of proteins taking part in inflammatory processes. Increased resistin concentrations are observed in cardiovascular complications. Resistin contributes to the onset of atherosclerosis and intensifies the atherosclerotic processes. The aim of this study was to investigate the relationship between resistin and cardiovascular (CV) risk in men with chronic kidney disease (CKD) not treated with dialysis. Materials and Methods: One hundred and forty-two men were included in the study: 99 men with eGFR lower than 60 mL/min/1.73 m2 and 43 men with eGFR ≥ 60 mL/min/1.73 m2. CV risk was assessed. Serum resistin, tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor-1 (PAI-1) were measured among other biochemical parameters. Results: We observed that resistin concentrations were significantly higher in patients with CKD compared to individuals with eGFR ≥ 60 mL/min/1.73 m2 (p = 0.003). In CKD, after estimating the general linear model (GLM), we found that resistin is associated with CV risk (p = 0.026) and PAI-1 serum concentrations (0.012). The relationship of PAI-1 with resistin depends on the level of CV risk in CKD (p = 0.048). Conclusions: Resistin concentrations rise with the increase of CV risk in CKD patients and thus resistin may contribute to the progression of cardiovascular risk in this group of patients. The relationship between resistin and CV risk is modified by PAI-1 concentrations.

Resistin in early diabetic chronic kidney disease: exploring the link with nutritional status and cardiovascular outcome

“…Increased resistin levels may be involved in the development of malnutritioninflammation states and, consequently, protein-energy wasting, a condition of paramount significance in the context of managing this population [21,22]. Our results corroborate this, showing higher plasma resistin levels in the malnourished group and a positive association with both IL-6 and PG-SGA scores.…”

“…Resistin has gained attention as a potential link between malnutrition, inflammation, and cardiovascular risk in patients with CKD [12,20,21].…”

Resistin: A Potential Indicator of Aortic Stiffness in Non-Dialysis Chronic Kidney Disease Patients

“…Our preceding research has further indicated that serum resistin levels could serve as a potential biomarker for aortic stiffness in patients with coronary artery disease (CAD) [ 10 ]. Importantly, resistin levels have recently been shown also to be elevated in CKD patients and could be associated with their higher risk of cardiovascular events [ 11 ].…”