Resistin polymorphims, plasma resistin levels and obesity in Tunisian volunteers

Zayani, Nesrine; Hamdouni, Haithem; Boumaiza, Imen; Achour, Ons; Neffati, Fadoua; Omezzine, Asma; Najjar, Mohamed Fadhel; Bouslama, Ali

doi:10.1002/jcla.22227

Cited by 20 publications

(12 citation statements)

References 66 publications

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“…SNPs are found in the RETN promoter and 3'-untranslated regions [14]. Genetic variation at the RETN locus carries a risk of several diseases, including the metabolic syndrome and colon cancer [15,16] and those with a functional RETN gene polymorphism at -420 (rs1862513) are at risk of developing type 2 diabetes [17,18], and associated with obesity in Tunisian population [19]. RETN SNPs have been found to correlated with worsening disease in Chinese Han patients with lung cancer [20].…”

Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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The adipokine resistin is linked with obesity, inflammation and various cancers, including breast cancer. This study sought to determine whether certain polymorphisms in the gene encoding resistin, RETN, increase the risk of breast cancer susceptibility. We analyzed levels of resistin expression in breast cancer tissue and samples from The Cancer Genome Atlas database. We also examined associations between four RETN single nucleotide polymorphisms (SNPs; rs3745367, rs7408174, rs1862513 and rs3219175) and breast cancer susceptibility in 515 patients with breast cancer and 541 healthy women without cancer. Compared with wild-type (GG) carriers, those carrying the AG genotype of the RETN SNP rs3219175 and those carrying at least one A allele in the SNP rs3219175 had a higher chance of developing breast cancer (adjusted odds ratio, AOR: 1.295, 95% confidence intervals, CI: 1.065-1.575 and 2.202, 1.701-2.243, respectively). When clinical aspects and the RETN SNP rs7408174 were examined in the breast cancer cohort, the CT genotype was linked to late-stage disease, while women with luminal A disease and at least one C allele were likely to progress to stage III/IV disease and to develop highly pathological grade III disease. Moreover, resistin-positive individuals were at greater risk than resistin-negative individuals for developing pathological grade III disease (OR: 5.020; 95% CI: 1.380-18.259). This study details risk associations between resistin and RETN SNPs in breast cancer susceptibility in Chinese Han women.

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Section: Ivyspringmentioning

confidence: 99%

Impacts of RETN genetic polymorphism on breast cancer development

et al. 2020

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“…A previous report demonstrated an association between resistin protein and an increased risk of T2DM (Gharibeh et al, 2010). Genetic variants of the gene that codes for resistin, called RETN, were shown to be linked with altered levels of resistin protein in a number of populations (Chen et al, 2010;Zayani et al, 2018). Given these reports, we tested the association of two single nucleotide polymorphisms in RETN, −420(C>G) and +299(G>A), with T2DM.…”

Section: Discussionmentioning

confidence: 97%

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

et al. 2021

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The global prevalence of type-two diabetes mellitus (T2DM) makes it a disease of public health concern. T2DM is strongly linked with insulin resistance caused by increased levels of visceral fat. Visceral fat secretes several adipocytokines that regulate body metabolism. Resistin is one of these adipocytokines which is encoded by the RETN gene. Herein, we tested the association of the RETN +299(G>A) and −420(C>G) single nucleotide polymorphisms (SNPs) with T2DM. T2DM patients (n=282) and healthy subjects (n=125) were included in the study. Subjects with metabolic syndromes other than diabetes were excluded. Genotyping of subjects was performed using PCR-RFLP. The +299(G>A) SNP was associated with T2DM (P=0.038). The AA genotype was higher in T2DM (17%) compared to controls (8%) with an odd ratio of 2.16 and 95% CI of 1.34 to 4.56. With respect to −420(C>G) SNP, no significant association was found with the risk of T2DM (P=0.128). The haplotype analysis of the examined SNPs indicated that the CA haplotype of the −420 and +299 SNPs in RETN was associated with T2DM risk (P=0.004; odd ration 4.0, 95% CI: 1.56–10.0). In conclusion, the present findings suggest a role of the RETN locus in modulating the risk of T2DM.

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“…RETN (ENSP00000221515) is a functional hormone that mediates the insulin capability to stimulate glucose uptake into adipose cells, thereby contributing to the normal regulation of endocrine functions [ 64 , 65 ]. Secreted by adipocytes, the protein coding by RETN may link obesity to type II diabetes considering its functional biological functions on regulating insulin activity and biological source [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective

Lei

Zhang

et al. 2017

Genes

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The number of obesity cases is rapidly increasing in developed and developing countries, thereby causing significant health problems worldwide. The pathologic factors of obesity at the molecular level are not fully characterized, although the imbalance between energy intake and consumption is widely recognized as the main reason for fat accumulation. Previous studies reported that obesity can be caused by the dysfunction of genes associated with other diseases, such as myocardial infarction, hence providing new insights into dissecting the pathogenesis of obesity by investigating its associations with other diseases. In this study, we investigated the relationship between obesity and diseases from Online Mendelian Inheritance in Man (OMIM) databases on the protein–protein interaction (PPI) network. The obesity genes and genes of one OMIM disease were mapped onto the network, and the interaction scores between the two gene sets were investigated on the basis of the PPI of individual gene pairs, thereby inferring the relationship between obesity and this disease. Results suggested that diseases related to nutrition and endocrine are the top two diseases that are closely associated with obesity. This finding is consistent with our general knowledge and indicates the reliability of our obtained results. Moreover, we inferred that diseases related to psychiatric factors and bone may also be highly related to obesity because the two diseases followed the diseases related to nutrition and endocrine according to our results. Numerous obesity–disease associations were identified in the literature to confirm the relationships between obesity and the aforementioned four diseases. These new results may help understand the underlying molecular mechanisms of obesity–disease co-occurrence and provide useful insights for disease prevention and intervention.

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Resistin polymorphims, plasma resistin levels and obesity in Tunisian volunteers

Abstract: The 420 C/G Polymorphism were associated with obesity and Leptin concentration in our population.

Cited by 20 publications

References 66 publications

Impacts of RETN genetic polymorphism on breast cancer development

Impacts of RETN genetic polymorphism on breast cancer development

Association of RETN +299(G>A) polymorphism with type two diabetes mellitus

Deciphering the Relationship between Obesity and Various Diseases from a Network Perspective

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