Resolution of Experimental Microvascular Vasoconstriction in Rats by Topical Application of Lidocaine Hydrochloride in Varying Concentrations

Wh, Beekman; Je, Sluimers; Wj, Kort; Jc, van der Meulen

doi:10.1097/00000637-198812000-00014

Cited by 20 publications

(17 citation statements)

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“…710 " 15 Topical application of local anesthetics is thought to produce vasodilation, 1617 and lidocaine has been frequently used in experimental situations. 18 " 20 Calcitonin gene-related peptide (CGRP) is regarded as one of the most potent vasodilator substances isolated. 21 It has been shown to be a pure vasodilator, with no constrictive effects, 2223 and it improves blood flow in experimental 2425 and clinical flaps.…”

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confidence: 99%

Effects of Calcitonin Gene-Related Peptide and Lidocaine on Mechanically-Induced Vasospasm in a Rat Island Flap

Gherardini

Jernbeck²,

Samuelson³

et al. 1995

J reconstr Microsurg

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A neurovascular island flap based on the superficial epigastric vessels was raised in 59 rats. Blood flow in the flap was recorded continuously with a laser Doppler flowmeter. Complete vasospasm was induced mechanically in the artery by pinching it. Calcitonin gene-related peptide (10(-7) M), lidocaine 2 percent, lidocaine 20 percent, or sodium chloride 0.9 percent were applied topically to the vessels in order to relieve the vasospasm. In 18 arteries, spasm was induced a second time after the resolution of the first vasospasm. Calcitonin gene-related peptide significantly shortened the time to reach 50 percent of the original blood flow and increased the final blood-flow values 30 min after mechanically-induced vasospasm, in comparison with pre-spasm values, and significantly increased the number of flaps in which the blood-flow values were restored to pre-spasm levels. Lidocaine did not significantly change the time to reach 50 percent of the original blood-flow values and the number of flaps recovering to pre-spasm blood-flow levels, or the final levels after vasospasm, in comparison with saline. It was concluded that, in this model, calcitonin gene-related peptide, but not lidocaine, increased blood flow after mechanically-induced vasospasm.

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confidence: 99%

Effects of Calcitonin Gene-Related Peptide and Lidocaine on Mechanically-Induced Vasospasm in a Rat Island Flap

Gherardini

Jernbeck²,

Samuelson³

et al. 1995

J reconstr Microsurg

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“…The clinically available spasmolytic vasodilators are categorized into five groups, including L‐type Ca 2+ channel blockers (nicardipine and diltiazem), phosphodiesterase inhibitors (papaverine), nitrovasodilators (TNG and SNP), vasodilatory prostaglandins (PGE 1 ), and anesthetics (lidocaine and pentobarbital) ( 1–7). Except for anesthetics, these vasodilators are known to inhibit the contraction of myocytes by reducing the concentration of cytosolic free Ca 2+ ([Ca 2+ ] i ) in these cells, although the precise mechanisms affecting [Ca 2+ ] i differ from each other ( 19–22).…”

Section: Discussionmentioning

confidence: 99%

“…The clinical and/or experimental use of several anesthetics as spasmolytic vasodilators has been reported ( 1–5), but the mechanism(s) of action of these drugs has not yet been clarified. It is known that lidocaine‐induced vascular relaxation is preceded by vasoconstriction ( 33).…”

Section: Discussionmentioning

confidence: 99%

“…A DMINISTRATION of vasodilators during reconstructive or vascular surgery is an important therapeutic procedure to prevent vascular spasm. A variety of pharmacological interventions, such as topical lidocaine ( 1–5), papaverine ( 2, 6), prostaglandin E 1 (PGE 1 ) ( 7), calcium (Ca 2+ ) channel blockers ( 1, 6), nitrovasodilators ( 6), and pentobarbital ( 5), has been developed for this purpose through clinical and/or experimental evaluation. Intravenous administration of these drugs is also believed to be beneficial in reducing the risk of no‐reflow phenomenon occurring after reperfusion ( 8–14).…”

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confidence: 99%

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Differential action of spasmolytic vasodilators on platelet aggregation and endothelial cell‐dependent anti‐aggregation

Azma

Saeki

Yuge

2000

Acta Anaesthesiol Scand

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“…For this reason, various kinds of vasodilators have been used to overcome the phenomenon. Several authors have suggested the use of vasodilators, such as lidocaine 4% (1,3,15) or chlorpromazine applied topically (2,4,7), and prostaglandin E1 (PGE1) (5,12,14) and diltiazem hydrochloride (9) given systemically. Each vasodilator has specific pharmacological effects such as initial action, duration, and peak time, when applied to the anastomosed vessel.…”

mentioning

confidence: 99%

The Blood Flow Patterns of Microsurgical Procedures in Rats With Topical and Systemic Vasodilators

Notodihardjo

Ogawa

Kusumoto

1998

Scandinavian Journal of Plastic and Reconstructive Surgery and

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The change in blood flow after anastomosis and the effects on the anastomosed artery of different classes of vasodilators such as lidocaine and chlorpromazine given topically (n = 10 in each group), and prostaglandin E1 (PGE1)(n = 12) and diltiazem hydrochloride (n = 10) given systemically, were investigated in the femoral arteries of rats. The blood flow after anastomosis decreased by 45%-60% compared with that before the anastomosis. Lidocaine showed almost the same pattern of blood flow as chlorpromazine. The former dilated the diameter of the vessel less than the latter, and the depression of the heart rate was less with lidocaine than in chlorpromazine. PGE1 had a longer and stronger vasodilatative action than diltiazem, and resulted in a remarkable increase in blood flow. Clinically, the topical application of chlorpromazine or lidocaine is recommended during an operation, and PGE1 should be given systemically after an operation to obtain adequate blood flow.

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Resolution of Experimental Microvascular Vasoconstriction in Rats by Topical Application of Lidocaine Hydrochloride in Varying Concentrations

Cited by 20 publications

References 0 publications

Effects of Calcitonin Gene-Related Peptide and Lidocaine on Mechanically-Induced Vasospasm in a Rat Island Flap

Effects of Calcitonin Gene-Related Peptide and Lidocaine on Mechanically-Induced Vasospasm in a Rat Island Flap

Differential action of spasmolytic vasodilators on platelet aggregation and endothelial cell‐dependent anti‐aggregation

The Blood Flow Patterns of Microsurgical Procedures in Rats With Topical and Systemic Vasodilators

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