Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study

Choi, Jung Yoo; Jung, Ui Won; Lee, In Seop; Kim, Chang Sung; Lee, Yong Keun; Choi, Seong Ho

doi:10.1111/j.1600-0501.2010.01978.x

Cited by 21 publications

(18 citation statements)

References 24 publications

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“…The amount of new bone formation at 8 weeks post‐surgery was largest in the BCP 60/40 group, which is consistent with the findings of previous studies . Furthermore, in our previous clinical studies, the human sinus and three‐wall intrabony defects adjacent to implants grafted using BCP demonstrated excellent new bone formation and maturation on the surface and in the macropores of BCP …”

Section: Discussionsupporting

confidence: 91%

“…MBCP, composed of HA and β‐TCP in a 60:40 weight ratio, has the total porosity, which is 70%. MBCP micropores are <10 μm and approximately 30% of the total porosity, whereas MBCP macropores are <600 μm and approximately 70–80% of the total porosity . MBCP+ composed of HA and β‐TCP in a 20:80 weight ratio with a macropore size range from 300 to 600 μm and global porosity around 80% (macroporosity: 80%, microporosity: 20%) .…”

Section: Methodsmentioning

confidence: 99%

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Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

et al. 2013

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Various synthetic bone substitutes have been developed to reconstruct the bony defects that clinicians often encounter during surgical procedures. Among various synthetic bone substitutes, calcium phosphate (Ca-P) ceramics have been investigated because their composition and structure are similar to those of human bone. We evaluated the bone healing and biodegradation patterns of three types of Ca-P ceramic particle with various hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) weight ratio: pure β-TCP, biphasic Ca-P (BCP) with a HA/β-TCP weight ratio of 60/40 (BCP 60/40), and BCP with an HA/β-TCP weight ratio of 20/80 (BCP 20/80). Four 8-mm-diameter defects were created in ten rabbits. Three of the defects in each rabbit were separately and randomly filled with one of the three experimental Ca-P ceramic particles, and the fourth was filled with blood clots (control). The specimens were harvested at 2 and 8 weeks post-surgery. The histologic and histometric findings revealed that the augmented space and new bone formation were significantly better for all three Ca-P ceramics than for the control group at both 2 and 8 weeks (p < 0.05). Compared to the pure β-TCP, the two BCP groups were found to provide a larger amount of newly formed bone and bone density at the 2- and 8-week post-operative periods (p < 0.05). Throughout the observation period, BCP 60/40 and BCP 20/80 exhibited a similar bone healing and biodegradation patterns with regard to both individual particles and the total augmented area in vivo.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

et al. 2013

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“…) whereby infra‐bony lesions respond favourably thus accounting for the discrepancy between the buccal and lingual sites in this study (Choi et al. ).…”

Section: Discussionmentioning

confidence: 56%

The use of endothelial progenitor cells combined with barrier membrane for the reconstruction of peri‐implant osseous defects: an animal experimental study

Machtei

Kim

Karimbux

et al. 2016

J Clinic Periodontology

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“…It has been detected in cartilage and other connective tissues [8]. Si is known as a key element in the early stages of the biomineralization process and it was reported as an HA inducer [9,10,11,12,13]. From the previous studies, we choose the amount of silicon and we substituted approximately 1 wt % of silicon in coral HA [6].…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model

Roh

Kim

Choi³

et al. 2016

Materials

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The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with β-tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:β-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.

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Resolution of surgically created three-wall intrabony defects in implants using three different biomaterials: an in vivo study

Cited by 21 publications

References 24 publications

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

The use of endothelial progenitor cells combined with barrier membrane for the reconstruction of peri‐implant osseous defects: an animal experimental study

Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and β-TCP in a Rat Calvarial Bone Defect Model

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