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2022
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“…A possible mechanism for nickel's ability to induce hypermethylation of DNA is that it substitutes for magnesium, accelerates condensation of chromatin and initiates de novo DNA methylation. 79 Furthermore, nickel has been shown to suppress histone H4 acetylation in yeast and mammalian cells in vitro , in addition to silencing genes by methylation. Nickel compounds are weakly mutagenic, despite their potency as carcinogens in humans and rodents.…”
Section: General Mechanism Of Nickel Carcinogenesismentioning
confidence: 99%
“…A possible mechanism for nickel's ability to induce hypermethylation of DNA is that it substitutes for magnesium, accelerates condensation of chromatin and initiates de novo DNA methylation. 79 Furthermore, nickel has been shown to suppress histone H4 acetylation in yeast and mammalian cells in vitro , in addition to silencing genes by methylation. Nickel compounds are weakly mutagenic, despite their potency as carcinogens in humans and rodents.…”
Section: General Mechanism Of Nickel Carcinogenesismentioning
confidence: 99%
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