Resolving Response, Decision, and Strategic Control: Evidence for a Functional Topography in Dorsomedial Prefrontal Cortex

Venkatraman, Vinod; Rosati, Alexandra G.; Taren, Adrienne A.; Huettel, Scott A.

doi:10.1523/jneurosci.2708-09.2009

Cited by 163 publications

(135 citation statements)

References 50 publications

(67 reference statements)

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“…As recently reported, some of these functions can be attributed to subregions of the DMPFC (Venkatraman et al, 2009a). The cluster that we identified overlaps with the subregions for decision control and strategy control in the study by Venkatraman et al (2009a). Because taking risks can be seen as acting against the dominant strategy of avoiding risks in riskaverse individuals, our findings are consistent with those previous findings about neural representations of strategy control.…”

Section: Discussionsupporting

confidence: 92%

“…These studies included investigations of response conflict, error monitoring, decision making, as well as strategy selection (for review, see Ridderinkhof et al, 2004;Venkatraman et al, 2009b). As recently reported, some of these functions can be attributed to subregions of the DMPFC (Venkatraman et al, 2009a). The cluster that we identified overlaps with the subregions for decision control and strategy control in the study by Venkatraman et al (2009a).…”

Section: Discussionmentioning

confidence: 59%

“…B, Left aINS was more likely to be activated if both gains and losses were possible outcomes, whereas DMPFC was more likely to be activated if only gains were possible. tant in the context of large brain regions that likely consist of subregions serving different functions (e.g., medial prefrontal cortex) (Venkatraman et al, 2009a). Note that an alternative approach for fMRI meta-analyses could summarize studies based on effect sizes (and their SEs).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Neural Processing of Risk

Mohr¹,

Biele²,

Heekeren³

2010

J. Neurosci.

378

302

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In our everyday life, we often have to make decisions with risky consequences, such as choosing a restaurant for dinner or choosing a form of retirement saving. To date, however, little is known about how the brain processes risk. Recent conceptualizations of risky decision making highlight that it is generally associated with emotions but do not specify how emotions are implicated in risk processing. Moreover, little is known about risk processing in non-choice situations and how potential losses influence risk processing. Here we used quantitative meta-analyses of functional magnetic resonance imaging experiments on risk processing in the brain to investigate (1) how risk processing is influenced by emotions, (2) how it differs between choice and non-choice situations, and (3) how it changes when losses are possible. By showing that, over a range of experiments and paradigms, risk is consistently represented in the anterior insula, a brain region known to process aversive emotions such as anxiety, disappointment, or regret, we provide evidence that risk processing is influenced by emotions. Furthermore, our results show risk-related activity in the dorsolateral prefrontal cortex and the parietal cortex in choice situations but not in situations in which no choice is involved or a choice has already been made. The anterior insula was predominantly active in the presence of potential losses, indicating that potential losses modulate risk processing.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neural Processing of Risk

Mohr¹,

Biele²,

Heekeren³

2010

J. Neurosci.

378

302

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show abstract

“…This was interpreted as a signal of experienced decision conflict, indicating that people detect their heuristic biases. Moreover, Venkatraman, Rosati, Taren, and Huettel (2009) showed that activation in the dmPFC presented an anterior-to-posterior topography based on varying control demands. That is, particularly a middle dmPFC region was associated with decision-related control and was shown to exhibit activation increasing with the difficulty in making decisions.…”

Section: Introductionmentioning

confidence: 99%

Neural Mechanisms Underlying Compensatory and Noncompensatory Strategies in Risky Choice

Duijvenvoorde

Figner

Weeda³

et al. 2016

Journal of Cognitive Neuroscience

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Abstract■ Individuals may differ systematically in their applied decision strategies, which has critical implications for decision neuroscience but is yet scarcely studied. Our study's main focus was therefore to investigate the neural mechanisms underlying compensatory versus noncompensatory strategies in risky choice. Here, we compared people using a compensatory expected value maximization with people using a simplified noncompensatory loss-minimizing choice strategy. To this end, we used a two-choice paradigm including a set of "simple" items (e.g., simple condition), in which one option was superior on all attributes, and a set of "conflict" items, in which one option was superior on one attribute but inferior on other attributes. A binomial mixture analysis of the decisions elicited by these items differentiated between decision-makers using either a compensatory or a noncompensatory strategy. Behavioral differences were particularly pronounced in the conflict condition, and these were paralleled by neural results. That is, we expected compensatory decision-makers to use an integrated value comparison during choice in the conflict condition. Accordingly, the compensatory group tracked the difference in expected value between choice options reflected in neural activation in the parietal cortex. Furthermore, we expected noncompensatory, compared with compensatory, decision-makers to experience increased conflict when attributes provided conflicting information. Accordingly, the noncompensatory group showed greater dorsomedial PFC activation only in the conflict condition. These pronounced behavioral and neural differences indicate the need for decision neuroscience to account for individual differences in risky choice strategies and to broaden its scope to noncompensatory risky choice strategies. ■

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“…Interestingly, recent conflict research suggests that increasing the level of abstractness leads to a shift of conflict-related brain activity in the anterior direction. In particular, it seems that posterior parts of the pFMC are related to response conflict, whereas anterior parts are related to other forms of conflict such as conflict between decisions and strategies (Pochon et al, 2008;Kouneiher et al, 2009;Venkatraman et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Errors and Conflict at the Task Level and the Response Level

Desmet¹,

Fias²,

Hartstra³

et al. 2011

J. Neurosci.

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In the last decade, research on error and conflict processing has become one of the most influential research areas in the domain of cognitive control. There is now converging evidence that a specific part of the posterior frontomedian cortex (pFMC), the rostral cingulate zone (RCZ), is crucially involved in the processing of errors and conflict. However, error-related research has focused primarily on a specific error type, namely, response errors. The aim of the present study was to investigate whether errors on the task level rely on the same neural and functional mechanisms. Here we report a dissociation of both error types in the pFMC: whereas response errors activate the RCZ, task errors activate the dorsal frontomedian cortex. Although this last region shows an overlap in activation for task and response errors on the group level, a closer inspection of the single-subject data is more in accordance with a functional anatomical dissociation. When investigating brain areas related to conflict on the task and response levels, a clear dissociation was perceived between areas associated with response conflict and with task conflict. Overall, our data support a dissociation between response and task levels of processing in the pFMC. In addition, we provide additional evidence for a dissociation between conflict and errors both at the response level and at the task level.

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Resolving Response, Decision, and Strategic Control: Evidence for a Functional Topography in Dorsomedial Prefrontal Cortex

Cited by 163 publications

References 50 publications

Neural Processing of Risk

Neural Processing of Risk

Neural Mechanisms Underlying Compensatory and Noncompensatory Strategies in Risky Choice

Errors and Conflict at the Task Level and the Response Level

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