Resolving "worm wars": An extended comparison review of findings from key economics and epidemiological studies

Majid, Muhammad Farhan; Kang, Su-Jin; Hotez, Peter J.

doi:10.1371/journal.pntd.0006940

Cited by 19 publications

(10 citation statements)

References 51 publications

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“…Periodic deworming with an inexpensive, safe, effective, single-tablet treatment - albendazole (400 mg) and mebendazole (500 mg), drastically relieves children infected with STH of the morbidities of the infection [ 11 ], and sometimes reverses the growth and physical fitness deficits caused by chronic STH infections [ 2 ]. Due to the sensitive and critical developmental formations that occur before the age of five, periodic deworming is, without a doubt, important in PSACs in endemic areas [ 8 , 12 , 13 ]. This is especially important in Nigeria where the prevalence of STH in this age group is high at 58.3% [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Perception and attitudinal factors contributing to periodic deworming of preschool children in an urban slum, Nigeria

et al. 2020

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Background Over 20 million preschool-age children (PSAC) in Nigeria require periodic chemotherapy (PC) for soil-transmitted helminth (STH) infections. Persistently low coverage for this age group threatens the World Health Organization (WHO) 2030 target for eliminating STH infections. Current strategies for targeting PSAC have been largely ineffective. Hence, PSAC are mostly dewormed by their parents/caregivers. However, little is known of the perception and attitude of parents/caregivers of PSAC to deworming in this setting. Methods A mixed methods design, combining a community-based interviewer-administered questionnaire-survey (n = 433) and focus group discussions (FGD) (n = 43) was used to assess the perceptions and attitudes of mothers to periodic deworming of preschool children aged 2–5 years in Abakpa-Nike, Enugu, Nigeria. Results Coverage of periodic deworming in PSAC is 42% (95% CI: 37.3–46.8%). There is significant difference in the specific knowledge of transmission of STH (AOR = 0.62, 95% CI: 0.48–0.81, p = 0.000), complication of STH infections (AOR = 0.77, 95% CI: 0.61–0.98, p = 0.034), accurate knowledge of deworming frequency (AOR = 0.41, 95% CI: 0.18–0.90, p = 0.026), and knowledge of PC drug, mebendazole (AOR = 0.28, 95% CI: 0.09–0.90, p = 0.031), and pyrantel (AOR = 8.03, 95% CI: 2.22–29.03, p = 0.001) between mothers who periodically deworm their PSAC and those who do not. There is no significant difference in specific knowledge of the symptoms of STH infections (AOR = 0.76, 95% CI: 0.57–1.02, p = 0.069) and PC drug, Albendazole (AOR = 1.00, 95% CI: 0.46–2.11, p = 0.972). FGD revealed misconceptions that are rooted in stark ignorance of the disease. Overall attitude to deworming is positive and favourable. Conclusions Poor coverage of periodic deworming for STH infections in PSAC in this setting are primarily driven by poor specific knowledge of the risks and burden of the infection. Focused health education on the burden and transmission of STH infections could complement existing strategies to improve periodic deworming of PSAC in this setting.

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Section: Introductionmentioning

confidence: 99%

Perception and attitudinal factors contributing to periodic deworming of preschool children in an urban slum, Nigeria

et al. 2020

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“…There has been ongoing controversy about the public health benefits of “deworming” via MDA and whether regular treatments of school-aged children can improve their school performance and contribute to greater educational achievement. 46 The SCORE investigators in Kenya attempted to rigorously investigate this issue by using a validated multidimensional survey instrument, the Behavioral Assessment System for Children (BASC-2), to assess emotional and behavioral problems among children in grades two through six. 15 Thirty-six children in six schools within S. mansoni –endemic communities near Lake Victoria were assessed both parasitologically and with the BASC-2 Teacher Rating Scale, both before and 3 weeks after MDA delivery.…”

Section: School Behavioral Assessment Studymentioning

confidence: 99%

SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection

King

Binder

Shen

et al. 2020

The American Journal of Tropical Medicine and Hygiene

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“…It is estimated that H. pylori infects more than 50% of the world population [ 9 , 10 ] with the highest burden among individuals living in low and middle-income countries (LMICs) [ 9 , 10 , 11 , 12 , 13 , 14 ]. Similarly, intestinal parasites affect millions of people globally [ 15 , 16 , 17 ], leading to a high probability of coinfection with H. pylori . Over the past decade, an impressive increase in migration flow has occurred in European countries including Italy, but little data about the rate of concomitant H. pylori -intestinal parasites infections in travelers is available [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

Pomari

Ursini

Silva

et al. 2020

JCM

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Background: Helicobacter pylori and intestinal parasites are estimated to infect with high burden worldwide. However, their concomitant infections are poorly determined in industrialized countries, such as Italy. In this study we aim at describing the presence of H. pylori as well as the proportion of coinfections with intestinal parasites among subjects who attended a referral center for tropical diseases in Northern Italy. Methods: This was a case-control study. Screening for H. pylori and parasites was performed on stool samples of 93 adults from different geographical origin (Africa, Asia, South-America, East-Europe and Italy). H. pylori infection was examined by CLIA and its cagA positivity was determined by rtPCR. Intestinal parasites (i.e., protozoa and helminths) were examined by microscopy and rtPCR. Results: Sixty-one out of 93 patients (66%) were positive to H. pylori and 31 (33%) were cagA+. Among H. pylori positives, 45 (74%) had a concomitant infection. The coinfection H. pylori–Blastocystis was the most frequent one, followed by H. pylori–E. coli. Multivariable logistic regression showed that positivity to H. pylori was associated with having a coinfection. Conclusion: Our data suggested that H. pylori and intestinal parasitic infections are fairly common in subjects who attended a referral center for tropical diseases in Northern Italy. The high rate of H. pylori infection, and especially the positivity to the virulent cagA+, should be taken into consideration in subjects undergoing screening for parasitic infections.

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Resolving "worm wars": An extended comparison review of findings from key economics and epidemiological studies

Cited by 19 publications

References 51 publications

Perception and attitudinal factors contributing to periodic deworming of preschool children in an urban slum, Nigeria

Perception and attitudinal factors contributing to periodic deworming of preschool children in an urban slum, Nigeria

SCORE Studies on the Impact of Drug Treatment on Morbidity due to Schistosoma mansoni and Schistosoma haematobium Infection

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

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