Resonant Waveguide Grating Biosensors Based on Label-free Optical Principle

Abstract

Label-free optical biosensors are powerful tools for the real-time monitoring of both molecular and cellular-scale interactions. Resonant waveguide grating biosensors are based on the detection of refractive index changes induced by molecular interactions and/or cell mass redistributions. The Epic BenchTop and Epic Cardio are two biosensors with high sensitivity and throughput that offer excellent potential for life science research. Both instruments are suitable for cell-based and biochemical assays. In this paper, I describe the principles of operation and performance of the Epic BenchTop and Epic Cardio label-free waveguide grating biosensors and discuss their applications in various research areas.