Resonant Waveguide Imaging of Living Systems: From Evanescent to Propagative Light

Argoul, Françoise; Berguiga, Lotfi; Elezgaray, Juan; Arnéodo, A.

doi:10.1007/978-94-007-5052-4_40

Cited by 1 publication

(1 citation statement)

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“…This problem was solved by Elezgaray and collaborators [34] by modeling and building a plasmonic microscope presenting sub-diffraction resolution imaging of the topography and of the refractive index. This method has been applied to the study of cellular systems [35]. One drawback is the relative complexity of this setup.…”

Section: Pwr Imagingmentioning

confidence: 99%

Plasmon Waveguide Resonance: Principles, Applications and Historical Perspectives on Instrument Development

et al. 2021

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Plasmon waveguide resonance (PWR) is a variant of surface plasmon resonance (SPR) that was invented about two decades ago at the University of Arizona. In addition to the characterization of the kinetics and affinity of molecular interactions, PWR possesses several advantages relative to SPR, namely, the ability to monitor both mass and structural changes. PWR allows anisotropy information to be obtained and is ideal for the investigation of molecular interactions occurring in anisotropic-oriented thin films. In this review, we will revisit main PWR applications, aiming at characterizing molecular interactions occurring (1) at lipid membranes deposited in the sensor and (2) in chemically modified sensors. Among the most widely used applications is the investigation of G-protein coupled receptor (GPCR) ligand activation and the study of the lipid environment’s impact on this process. Pioneering PWR studies on GPCRs were carried out thanks to the strong and effective collaboration between two laboratories in the University of Arizona leaded by Dr. Gordon Tollin and Dr. Victor J. Hruby. This review provides an overview of the main applications of PWR and provides a historical perspective on the development of instruments since the first prototype and continuous technological improvements to ongoing and future developments, aiming at broadening the information obtained and expanding the application portfolio.

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Section: Pwr Imagingmentioning

confidence: 99%