Respiratory depression during epidural morphine treatment

Abstract

An 81-year-old woman was treated for 2 weeks with systemic opioids and for 2 days with epidural morphine before a severe and prolonged respiratory depression occurred.

Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration

“…[70][71][72][73][74][75][76][77][78][79] RCTs comparing naloxone 80,81 or naltrexone [82][83][84] with placebo are equivocal regarding preprocedure prophylaxis for respiratory depression, hypoxemia, sedation, or somnolence (Category A2-E evidence). [70][71][72][73][74][75][76][77][78][79] RCTs comparing naloxone 80,81 or naltrexone [82][83][84] with placebo are equivocal regarding preprocedure prophylaxis for respiratory depression, hypoxemia, sedation, or somnolence (Category A2-E evidence).…”