Respiratory disease caused by a species B2Adenovirus in a military camp in Turkey

Chmielewicz, Barbara; Benzler, Justus; Pauli, Georg; Krause, Gérard; Bergmann, Frank; Schweiger, Brunhilde

doi:10.1002/jmv.20441

Cited by 86 publications

(84 citation statements)

References 33 publications

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“…Analysis of an earlier described "HAdV-B11a" hexon (GenBank accession no. AY972815) (2) shows it is identical to the one embedded in the "QS" genome (23), suggesting that "HAdVB11a" was incorrectly characterized earlier as a variant of HAdV-B11 (2,6,11,22) by the use of "then-available" assays. Serum neutralization has the hexon as its target, as does limited molecular typing (3,13).…”

mentioning

confidence: 99%

“…Since genome rearrangements are missed by serological and molecular assays against a limited repertoire, it is problematic to rely solely on these methods to characterize a virus thoroughly. Thus, due to the limitations of these assays, the original "HAdV-B11a" isolates have been misnamed as well (2,6,11).…”

mentioning

confidence: 99%

“…By inference, the cell recognition epitope is either the distal 68.1% of the HAdV-B14 hexon or the fiber, rather than the proximal 31.9% encompassing "loops 1 and 2" of the HAdV-B11 hexon. Although originally identified in sporadic and infrequent historical ARD outbreaks by serum neutralization as "HAdV-B11-like" and recently recharacterized by immunochemistry (serum neutralization and enzyme-linked immunosorbent assay [ELISA]) and limited molecular typing (PCR and hexon sequencing) also as "HAdV-B11-like" (2,6,11,22), genomics and bioinformatics demonstrate that it is a novel type. All of these older techniques, assaying only the hexon gene, simply reconfirmed a HAdV-B11-like hexon epitope.…”

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confidence: 99%

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Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

et al. 2010

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Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

et al. 2010

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“…The B1 viruses adenovirus type 3 (Ad3), Ad7, Ad16, Ad21, and Ad50 (Ad3/7/16/21/50) predominantly infect the upper respiratory tract, whereas the B2 viruses Ad11/14/34/35 are associated with kidney and urinary tract infections with fatal outcomes in immunocompromised patients (30,54,68). Recent epidemiological reports described the reemergence of several of these virus types associated with outbreaks of respiratory disease (7,32,39,77). The tropism of species B viruses is broader than that of the C species and includes cancer cells, dendritic cells, and hematopoietic stem cells.…”

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Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection

Trinh

Lesage

Chennamparampil

et al. 2012

J Virol

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The species B human adenoviruses (HAdVs) infect cells upon attaching to CD46 or desmoglein 2 (DSG-2) by one or several of their 12 fiber knob trimers (FKs). To test whether DSG-2 and CD46 simultaneously serve as virus receptors for adenovirus type 3 (Ad3), we performed individual and combined CD46/DSG-2 loss-of-function studies in human lung A549 and 16HBE14o cells. Our results suggest that in these cells, DSG-2 functions as a major attachment receptor for Ad3, whereas CD46 exerts a minor contribution to virus attachment and uptake in the range of ϳ10%. However, in other cells the role of CD46 may be more pronounced depending on, e.g., the expression levels of the receptors. To test if avidity allows Ad3/7 to use CD46 as a receptor, we performed gain-of-function studies. The cell surface levels of ectopically expressed CD46 in CHO or human M010119 melanoma cells lacking DSG-2 positively correlated with Ad3/7 infections, while Ad11/35 infections depended on CD46 but less on CD46 levels. Antibody-cross-linked soluble CD46 blocked Ad3/7/11/35 infections, while soluble CD46 alone blocked Ad11/35 but not Ad3/7. Soluble Ad3/7-FKs poorly inhibited Ad3/7 infection of CHO-CD46 cells, illustrating that Ad3/7-FKs bind with low affinity to CD46. This was confirmed by Biacore studies. Ad3/7-FK binding to immobilized CD46 at low density was not detected, unlike that of Ad11/35-FK. At higher CD46 densities, however, Ad3/7-FK bound to CD46 with only 15-fold-higher dissociation constants than those of Ad11/35-FK. These data show that an avidity mechanism for Ad3/7 binding to CD46 leads to infection of CD46-positive cells.

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“…The sole HAdV-E serotype, HAdV-4, and several HAdV-B serotypes, including HAdV-3, HAdV-7, and HAdV-21, are commonly associated with epidemic outbreaks of FRI and pneumonia in healthy adults and children throughout the world (16,17,24,21). Two other HAdV-B serotypes, HAdV-11a and HAdV-14, had, until recently, been identified only in association with respiratory disease epidemics in rare (though severe) outbreaks in Eurasia (3,5,16). Prior to the turn of the century, HAdV-14 had never been isolated from any case in North or South America (16).…”

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Adenovirus Microsatellite Reveals Dynamics of Transmission during a Recent Epidemic of Human Adenovirus Serotype 14 Infection

Houng

Lott²,

Gong

et al. 2009

J Clin Microbiol

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This study reveals diverse-length polymorphisms in long mononucleotide repeats (microsatellites) in several serotypes of epidemic human respiratory adenovirus. The length of one of these microsatellites, a homopolymeric thymidine [poly(T)] repeat, is measured in 68 isolates of adenovirus serotype 14. These isolates were collected during a series of sudden and sometimes fatal outbreaks among both military recruits and civilians as the virus emerged for the first time in the United States in 2006 and 2007. The results demonstrate the usefulness of adenoviral microsatellites as high-resolution molecular strain markers. The described homopolymer is hypervariable in length, varying from 12 to 17 bp in the analyzed sample set. All intermediate lengths were identified in at least one isolate. Furthermore, the specific length of the marker is stable for significant periods of time (up to 7 months) at individual sites where the virus is in consistent circulation. The microsatellite also can maintain specific length identity through site-to-site transmission events, as determined by the analysis of isolates from three advanced training sites that appeared to be subject to pathogen transfer from one of the affected recruit training installations. Public database searches revealed that the polymorphic nature of the microsatellite extends to other species B serotypes, and that other polymorphic microsatellites can be identified readily in a variety of epidemic respiratory adenovirus clades. This study shows that microsatellites are a ubiquitous source of polymorphic markers for human adenoviruses and demonstrates their use through an epidemiological analysis of isolates from a recent North American epidemic.

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Respiratory disease caused by a species B2Adenovirus in a military camp in Turkey

Abstract: virus with the highest similarity to adenovirus type 11a.3

Cited by 86 publications

References 33 publications

Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

Computational Analysis Identifies Human Adenovirus Type 55 as a Re-Emergent Acute Respiratory Disease Pathogen

Avidity Binding of Human Adenovirus Serotypes 3 and 7 to the Membrane Cofactor CD46 Triggers Infection

Adenovirus Microsatellite Reveals Dynamics of Transmission during a Recent Epidemic of Human Adenovirus Serotype 14 Infection

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