Respiratory muscle activation and action during voluntary cough in healthy humans

LoMauro, Antonella; Aliverti, Andréa

doi:10.1016/j.jelekin.2019.102359

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…Except for age, the results are presented as the mean ± standard error of the mean (SEM). We did not statistically determine the sample size, but our sample sizes are comparable to those reported in previous publications [25,26]. Reproducibility of the airflow and EMG parameters was evaluated using the intraclass correlation coefficient (ICC).…”

Section: Discussionmentioning

confidence: 86%

Comparison of physical properties of voluntary coughing, huffing and swallowing in healthy subjects

et al. 2020

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Coughing, huffing and swallowing protect the airway from aspiration. This study was conducted to compare the physical properties of voluntary coughing, huffing and swallowing in healthy subjects. Ten healthy men were asked to huff, cough and swallow repeatedly. Electromyograms (EMGs) were recorded from the left side of the external oblique (EO), sternocleidomastoid, suprahyoid (SH) and thyrohyoid muscles. Airflow was recorded using a face mask with two-way non-rebreathing valves. The expiratory velocity of huffing and coughing and the SH EMG of all actions presented high intraclass correlation coefficients (> 0.8). The inspiratory and expiratory velocities did not differ significantly between coughing and huffing. The expiratory acceleration of coughing was significantly higher than that of huffing, whereas the expiratory volume of coughing was significantly smaller than that of huffing. The EO EMG of coughing and huffing were significantly larger than that of swallowing. The EO EMG activity during the expiratory phase was significantly higher than that of the other phases of both coughing and huffing. The SH EMG of coughing and huffing were significantly smaller than that of swallowing. Correlation analysis revealed that the expiratory velocity of coughing was strongly positively correlated with that of huffing. The expiratory volume of huffing was significantly positively correlated with hand grip strength. These results suggest that EO and SH muscle activities during huffing or coughing differ those during swallowing, and huffing and coughing may work similarly in expiratory function.

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Section: Discussionmentioning

confidence: 86%

Comparison of physical properties of voluntary coughing, huffing and swallowing in healthy subjects

et al. 2020

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“…A five‐millimeter‐diameter probe with three surface electrodes (Personalmed, Redmond, WA 98052) was placed in the anal canal. For abdominal wall EMG, three surface electrodes were placed on the lateral abdominal wall 12 . The EMG signals were measured in microvolts and recorded using the Aware EMG recording device (SRS Medical, Billerica, MA 01862).…”

Section: Methodsmentioning

confidence: 99%

“…For abdominal wall EMG, three surface electrodes were placed on the lateral abdominal wall. 12 The EMG signals were measured in microvolts and recorded using the Aware EMG recording device (SRS Medical, Billerica, MA 01862). The patient was asked to lie in the left lateral position for these recordings and perform following maneuvers: cough three times, voluntary anal squeeze maneuver three times, and push three times.…”

Section: Electromyography (Emg)mentioning

confidence: 99%

Fecal incontinence patients categorized based on anal pressure and electromyography: Anal sphincter damage and clinical symptoms

Swartz,

Zifan,

Tuttle

et al. 2024

Neurogastroenterology Motil

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BackgroundDisruption of external anal sphincter muscle (EAS) is an important factor in the multifactorial etiology of fecal incontinence (FI).ObjectivesWe categorize FI patients into four groups based on the location of lesion in neuromuscular circuitry of EAS to determine if there are differences with regards to fecal incontinence symptoms severity (FISI) score, age, BMI, obstetrical history, and anal sphincter muscle damage.MethodsFemale patients (151) without any neurological symptoms, who had undergone high‐resolution manometry, anal sphincter EMG, and 3D ultrasound imaging of the anal sphincter were assessed. Patients were categorized into four groups: Group 1 (normal)—normal cough EMG (>10 μV), normal squeeze EMG (>10 μV), and normal anal squeeze pressure (>124 mmHg); Group 2 (cortical apraxia, i.e., poor cortical activation)—normal cough EMG, low squeeze EMG, and low anal squeeze pressure; Group 3 (muscle damage)—normal cough EMG, normal squeeze EMG, and low anal squeeze pressure; and Group 4 (pudendal nerve damage)—low cough EMG, low squeeze EMG, and low anal squeeze pressure.ResultsThe four patient groups were not different with regards to the patient's age, BMI, parity, and FISI scores. 3D ultrasound images of the anal sphincter complex revealed significant damage to the internal anal sphincter, external anal sphincter, and puborectalis muscles in all four groups.ConclusionThe FI patients are a heterogeneous group; majority of these patients have significant damage to the muscles of the anal sphincter complex. Whether biofeedback therapy response is different among different patient groups requires study.

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“…PCF data were collected with a heated pneumotachograph (HR 3500B, 3700B, or 3813 Hans Rudolph, Shawnee, KS) connected to the tracheostomy or facemask. Since PCF can be influenced by inspiratory operating volume ( 40 ), patients above 4 years of age were instructed to take a deep breath and cough as forcefully as possible. Spontaneous coughs were recorded in preschool-aged children.…”

Section: Methodsmentioning

confidence: 99%

Diaphragm pacing and independent breathing in individuals with severe Pompe disease

Liberati

Byrne

Fuller

et al. 2023

Front. Rehabil. Sci.

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IntroductionPompe disease is an inherited disease characterized by a deficit in acid-α-glucosidase (GAA), an enzyme which degrades lysosomal glycogen. The phrenic-diaphragm motor system is affected preferentially, and respiratory failure often occurs despite GAA enzyme replacement therapy. We hypothesized that the continued use of diaphragm pacing (DP) might improve ventilator-dependent subjects' respiratory outcomes and increase ventilator-free time tolerance.MethodsSix patients (3 pediatric) underwent clinical DP implantation and started diaphragm conditioning, which involved progressively longer periods of daily, low intensity stimulation. Longitudinal respiratory breathing pattern, diaphragm electromyography, and pulmonary function tests were completed when possible, to assess feasibility of use, as well as diaphragm and ventilatory responses to conditioning.ResultsAll subjects were eventually able to undergo full-time conditioning via DP and increase their maximal tolerated time off-ventilator, when compared to pre-implant function. Over time, 3 of 6 subjects also demonstrated increased or stable minute ventilation throughout the day, without positive-pressure ventilation assistance.DiscussionRespiratory insufficiency is one of the main causes of death in patients with Pompe disease. Our results indicate that DP in Pompe disease was feasible, led to few adverse events and stabilized breathing for up to 7 years.

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Respiratory muscle activation and action during voluntary cough in healthy humans

Cited by 12 publications

References 30 publications

Comparison of physical properties of voluntary coughing, huffing and swallowing in healthy subjects

Comparison of physical properties of voluntary coughing, huffing and swallowing in healthy subjects

Fecal incontinence patients categorized based on anal pressure and electromyography: Anal sphincter damage and clinical symptoms

Diaphragm pacing and independent breathing in individuals with severe Pompe disease

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