Respiratory self-gated 3DUTE for lung imaging in small animal MRI

Tibiletti, Marta; Bianchi, Andrea; Kjørstad, Åsmund; Wundrak, Stefan; Stiller, Detlef; Rasche, Volker

doi:10.1002/mrm.26463

Cited by 14 publications

(18 citation statements)

References 22 publications

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“…We implemented a 3D Ultrashort Echo Time (UTE) sequence with 1.5 mm isotropic voxel size and 2 ms repetition time (TR) at 3 T to acquire 3D images for 32 phases over a time-averaged human respiratory cycle by retrospective self-gating. This pulse sequence was demonstrated to be particularly well adapted to dynamic lung imaging 19 . Once displacement fields were computed from the 32 registered images, we prospected a set of metrics to obtain time-resolved 3D voxel-wise information of pulmonary ventilation and mechanical behavior throughout the entire respiratory cycle.…”

mentioning

confidence: 99%

3D Magnetic Resonance Spirometry

Boucneau

Fernandez²,

Larson

et al. 2020

Sci Rep

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Spirometry is today the gold standard technique for assessing pulmonary ventilatory function in humans. From the shape of a flow-volume loop measured while the patient is performing forced respiratory cycles, the Forced Vital Capacity (FVC) and the Forced Expiratory Volume in one second (FEV1) can be inferred, and the pulmonologist is able to detect and characterize common respiratory afflictions. This technique is non-invasive, simple, widely available, robust, repeatable and reproducible. Yet, its outcomes rely on the patient’s cooperation and provide only global information over the lung. With 3D Magnetic Resonance (MR) Spirometry, local ventilation can be assessed by MRI anywhere in the lung while the patient is freely breathing. The larger dimensionality of 3D MR Spirometry advantageously allows the extraction of original metrics that characterize the anisotropic and hysteretic regional mechanical behavior of the lung. Here, we demonstrated the potential of this technique on a healthy human volunteer breathing along different respiratory patterns during the MR acquisition. These new results are discussed with lung physiology and recent pulmonary CT data. As respiratory mechanics inherently support lung ventilation, 3D MR Spirometry may open a new way to non-invasively explore lung function while providing improved diagnosis of localized pulmonary diseases.

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confidence: 99%

3D Magnetic Resonance Spirometry

Boucneau

Fernandez²,

Larson

et al. 2020

Sci Rep

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“…Unlike previous motion‐resolved lung MRI studies, we have demonstrated the feasibility of applying XD‐UTE for evaluation of both lung anatomy and ventilation in this work. In addition, our XD‐UTE technique uses a self‐navigated golden‐angle UTE sequence, which enables more efficient respiratory motion detection and leads to faster image reconstruction speed.…”

Section: Discussionmentioning

confidence: 99%

“…However, both of these two studies aimed to reconstruct high‐resolution, high‐quality anatomical lung images only. Tibiletti et al also demonstrated the performance of XD‐GRASP for lung imaging in small animal MRI, but it is not trivial to study ventilation of the lung in animal. In this study, we aimed to move one step further to extend this framework, so that it can be used for assessing not only lung anatomy, but also pulmonary ventilation in clinical studies.…”

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confidence: 99%

Simultaneous Evaluation of Lung Anatomy and Ventilation Using 4D Respiratory‐Motion‐Resolved Ultrashort Echo Time Sparse MRI

Feng

Delacoste

Smith

et al. 2018

Magnetic Resonance Imaging

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Background: Computed tomography (CT) and spirometry are the current standard methods for assessing lung anatomy and pulmonary ventilation, respectively. However, CT provides limited ventilation information and spirometry only provides global measures of lung ventilation. Thus, a method that can enable simultaneous examination of lung anatomy and ventilation is of clinical interest. Purpose: To develop and test a 4D respiratory-resolved sparse lung MRI (XD-UTE: eXtra-Dimensional Ultrashort TE imaging) approach for simultaneous evaluation of lung anatomy and pulmonary ventilation. Study Type: Prospective. Population: In all, 23 subjects (11 volunteers and 12 patients, mean age = 63.6 ± 8.4). Field Strength/Sequence: 3T MR; a prototype 3D golden-angle radial UTE sequence, a Cartesian breath-hold volumetricinterpolated examination (BH-VIBE) sequence. Assessment: All subjects were scanned using the 3D golden-angle radial UTE sequence during normal breathing. Ten subjects underwent an additional scan during alternating normal and deep breathing. Respiratory-motion-resolved sparse reconstruction was performed for all the acquired data to generate dynamic normal-breathing or deep-breathing image series. For comparison, BH-VIBE was performed in 12 subjects. Lung images were visually scored by three experienced chest radiologists and were analyzed by two observers who segmented the left and right lung to derive ventilation parameters in comparison with spirometry. Statistical Tests: Nonparametric paired two-tailed Wilcoxon signed-rank test; intraclass correlation coefficient, Pearson correlation coefficient. Results: XD-UTE achieved significantly improved image quality compared both with Cartesian BH-VIBE and radial reconstruction without motion compensation (P < 0.05). The global ventilation parameters (a sum of the left and right lung measures) were in good correlation with spirometry in the same subjects (correlation coefficient = 0.724). There were excellent correlations between the results obtained by two observers (intraclass correlation coefficient ranged from 0.8855-0.9995).View this article online at wileyonlinelibrary.com.

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“…Despite relatively high temporal and spatial resolutions, the sophisticated polarization procedure and the limited availability of 3 He restrict clinical dissemination. Several alternative techniques were proposed to map lung ventilation/perfusion, by using self‐gated 3D ultrashort echo time (UTE), Fourier decomposition and self‐gated non‐contrast‐enhanced functional lung imaging . Another promising alternative to hyperpolarized gas lung MRI relies on contrast enhancement with the use of gadolinium (Gd)‐based aerosol administration .…”

Section: Introductionmentioning

confidence: 99%

Quantitative Gd‐DOTA‐based aerosol deposition mapping in the lungs of asthmatic rats using 3D UTE‐MRI

et al. 2018

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Asthma is a chronic respiratory disease, commonly treated with inhaled therapy. Better understanding of the mechanisms of aerosol deposition is required to improve inhaled drug delivery. Three‐dimensional ultrashort echo time (UTE) MRI acquisitions at 1.5 T were combined with spontaneous nose‐only inhalation of aerosolized gadolinium (Gd) to map the aerosol deposition and to characterize signal enhancement in asthmatic rat lungs. The rats were sensitized to ovalbumin (OVA) to develop asthmatic models and challenged before imaging by nebulization of OVA to trigger asthmatic symptoms. The negative controls were not sensitized or challenged by nebulization of saline. The animal lungs were imaged before and after administration of Gd‐based aerosol in freely breathing rats, by using a T1‐weighted 3D UTE sequence. A contrast‐enhanced quantitative analysis was performed to assess regional concentration. OVA‐sensitized rats had lower signal enhancement and lower deposited aerosol concentration. Their enhancement dynamics showed large inter‐subject variability. The signal intensity was homogeneously enhanced for controls while OVA‐sensitized rats showed heterogeneous enhancement. Contrast‐enhanced 3D UTE was applied with aerosolized Gd to efficiently measure spatially resolved deposition in asthmatic lungs. The small administered dose (around 1 μmol/kg body weight) and the use of standard clinical MRI suggest a potential application for the exploration of asthma.

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Respiratory self-gated 3DUTE for lung imaging in small animal MRI

Cited by 14 publications

References 22 publications

3D Magnetic Resonance Spirometry

3D Magnetic Resonance Spirometry

Simultaneous Evaluation of Lung Anatomy and Ventilation Using 4D Respiratory‐Motion‐Resolved Ultrashort Echo Time Sparse MRI

Quantitative Gd‐DOTA‐based aerosol deposition mapping in the lungs of asthmatic rats using 3D UTE‐MRI

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