2020
DOI: 10.1128/jvi.01380-20
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Respiratory Syncytial Virus Sequesters NF-κB Subunit p65 to Cytoplasmic Inclusion Bodies To Inhibit Innate Immune Signaling

Abstract: Viruses routinely employ strategies to prevent the activation of innate immune signalling in infected cells. RSV is no exception, encoding two accessory proteins (NS1 and NS2) which are well established to block Interferon signalling. However, RSV-encoded mechanisms for inhibiting NF-κB signalling are less well characterised. In this study we identified RSV-mediated antagonism of this pathway, independent of the NS1 and NS2 proteins, and indeed distinct from other known viral mechanisms of NF-κB inhibition. In… Show more

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Cited by 78 publications
(76 citation statements)
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(91 reference statements)
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“…As studies progressed, these IBs more commonly became referred to as viral factories, viroplasms, and virosomes [ 51 ]. Because the term inclusion bodies is also widely used by biologists and biochemists to describe the insoluble aggregates formed by unfolded or misfolded proteins, it has been proposed to rename these structures or define them based on an identifiable marker [ 52 ]. While the field awaits consensus of a new nomenclature, we will adopt the conventional terminology throughout the article.…”
Section: The Nature and Formation Of Viral Liquid-like Organellesmentioning
confidence: 99%
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“…As studies progressed, these IBs more commonly became referred to as viral factories, viroplasms, and virosomes [ 51 ]. Because the term inclusion bodies is also widely used by biologists and biochemists to describe the insoluble aggregates formed by unfolded or misfolded proteins, it has been proposed to rename these structures or define them based on an identifiable marker [ 52 ]. While the field awaits consensus of a new nomenclature, we will adopt the conventional terminology throughout the article.…”
Section: The Nature and Formation Of Viral Liquid-like Organellesmentioning
confidence: 99%
“…Whether the formation of IBs with liquid properties represents a universal feature of NNS RNA viruses remains to be determined. Based on the spherical morphology of RSV IBs [ 52 ] and the diffusion of N protein observed for the pseudo IBs formed in transfected cells [ 71 ], it is very likely that RSV IBs are membrane-less liquid organelles. Moreover, evidence was provided that these IBs are sites of RSV replication.…”
Section: The Nature and Formation Of Viral Liquid-like Organellesmentioning
confidence: 99%
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