Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs

Panickar, Avani; Manoharan, Anand; Anbarasu, Anand; Ramaiah, Sudha

doi:10.1007/s00203-024-04107-z

Arch Microbiol

2024

DOI: 10.1007/s00203-024-04107-z

|View full text |Cite

Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs

Avani Panickar,

Anand Manoharan,

Anand Anbarasu

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 212 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Mohamed,

Mohammed,

El-Gebaly

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Healtcare-associated infections have increased due to the development of antimicrobial resistance (AMR) of Gram-negative pathogens (GNPs) and the development of outbreacks over the past two decades. In this work, we investigated how exposure to positive electric pulses affects the growth characteristics of Klebsiella pneumonia (K. pneumonia), a common cause of pneumonia. We explored the impact of varying exposure frequencies (0.2–2 Hz) and time (15–90 min, at resonance frequency) on bioelectric signals produced during cell division, biofilm formation, and bacterial antibiotic susceptibility. Our research found that an extremely low-frequency pulsed electric field (ELF-PEF) significantly inhibited K. pneumonia growth. Specifically, exposure to 0.8 Hz for one hour increased the antibiotic susceptibility of K. pneumonia to inhibitors of cell wall formation, proteins, β-lactamase, DNA, and other substances. We also noticed a notable decrease in K. pneumonia biofilm development exposed to ELF-PEF. Our results suggest that the interaction of K. pneumonia cells with ELF-PEF at the specified frequency and time alters cellular activity and bacterial structure. This technique may be used in the future to treat K. pneumonia infections both in vitro and in vivo.

show abstract

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Mohamed,

Mohammed,

El-Gebaly

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Respiratory tract infections: an update on the complexity of bacterial diversity, therapeutic interventions and breakthroughs

Cited by 1 publication

References 212 publications

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Contact Info

Product

Resources

About