Response- and remission rates as efficacymarker of monotherapy with atypical neuroleptics in the treatment of acute mania

Abstract

studies also indicated it may be helpful to depression. Will it be helpful if treating the adolescent bipolar disorder? Method: 76 patients were randomized into two groups, 37 treated with capsule Acanthopanax senticosus plus tablet lithium, 39 treated with capsule fluoxetine plus tablet lithium. Hamilton depression rating scale, 17 items (HAMD-17) was assessed during the trial. Result: After 6 weeks treatment, There was a main effect for duration of treatment for Hamilton depression scale scores (F¼183.06, P<0.01), but there was no group main effect(F¼0.99, P¼0.323) or group-by-duration of treatment interaction(F¼0.779, P¼0.437). The response rate and remission rate between the two group were similar. 3 patients suffered mood switching in fluoxetine treated group while no patients in Acanthopanax senticosus treated group. Conclusion: This preliminary study suggested that lithium adding Acanthopanax senticosus was as effective as lithium adding fluoxetine for treating adolescent bipolar depression, and Acanthopanax senticosus may be more safer and less risk to mood switching.