Response Surface Methodology Approach to the Optimization of Potato (Solanum tuberosum) Tuber Yield Using Second-Order Rotatable Design

Jk, Koech; Mj, Mutiso; Jk, Koskei

doi:10.4172/2155-6180.1000351

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…SAXS analysis corroborated these findings, confirming successful cargo loading into the JBNt. Following its validation, RSM has been effectively utilized to enhance encapsulation efficiency, eliminating the need for repetitive trials to identify the optimal method [34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

Lee,

Zhang,

Nguyen

et al. 2024

Preprint

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Despite the development of various drug delivery technologies, there remains a significant need for vehicles that can improve targeting and biodistribution in hard-to-penetrate tissues. Some solid tumors, for example, are particularly challenging to penetrate due to their dense extracellular matrix (ECM). In this study, we have formulated a new family of rod-shaped delivery vehicles named Janus base nanopieces (Rod JBNps), which are more slender than conventional spherical nanoparticles, such as lipid nanoparticles (LNPs). These JBNp nanorods are formed by bundles of DNA-inspired Janus base nanotubes (JBNts) with intercalated delivery cargoes. To develop this novel family of delivery vehicles, we employed a computation-aided design (CAD) methodology that includes molecular dynamics and response surface methodology. This approach precisely and efficiently guides experimental designs. Using an ovarian cancer model, we demonstrated that JBNps markedly improve penetration into the dense ECM of solid tumors, leading to better treatment outcomes compared to FDA-approved spherical LNP delivery. This study not only successfully developed a rod-shaped delivery vehicle for improved tissue penetration but also established a CAD methodology to effectively guide material design.

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Section: Discussionmentioning

confidence: 99%

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

Lee,

Zhang,

Nguyen

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Response Surface Methodology Approach to the Optimization of Potato (Solanum tuberosum) Tuber Yield Using Second-Order Rotatable Design

Abstract: Citation: Koech JK, Mutiso MJ, Koskei JK (2017) Response Surface Methodology Approach to the Optimization of Potato (Solanum tuberosum) Tuber Yield Using Second-Order Rotatable Design. J Biom Biostat 8: 351.

Cited by 1 publication

References 12 publications

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

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