Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions

Abstract

Resveratrol, a strong antioxidant and anti-inflammatory phytoalexin is potential to relieve impaired diabetic wound healing. Self-assembly nanoemulsions were developed to formulate good quality of resveratrol topical preparation. The surfactant system consisted of Kolliphor® RH 40 and Transcutol® were further optimized in terms of viscosity, pH and the percentage of transmittance. A central composite design combined with the response surface methodology successfully resulted in surface responses with the desirability value for viscosity, pH, and transmittance percentage were 0.99742, 0.60598, and 0.37137, respectively. These results contributed to the composite desirability of 0.6077. The optimal condition was obtained at a composition 5.70 g and 2.30 g of Kolliphor® RH 40 and Transcutol®, correspondingly.