Response surface methodology (RSM) for optimization of cadmium ions adsorption using C16-6-16 incorporated mesoporous MCM-41

Saini, Suman; Chawla, Jyoti; Kumar, Rajeev; Kaur, Inderpreet

doi:10.1007/s42452-019-0922-5

Cited by 28 publications

(12 citation statements)

References 26 publications

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“…The response of the system is represented graphically in three dimensions, with highlighting of the interactions between the formulation factors [32].…”

Section: Optimization Of Colloidal Systems With In Situ Gelling Based On Chitosan and Hpmc E 5 LV Using Response Surface Analysismentioning

confidence: 99%

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

et al. 2021

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The aim of this study was the development and optimization of chitosan and hydroxypropyl methylcellulose (HPMC) in situ gelling systems, loaded with bupivacaine hydrochloride for topical ocular administration. This study is based on the properties of two polymers: chitosan, which has mucoadhesive action and is a pH-sensitive polymer, but also the cellulose derivative hydroxypropyl methylcellulose, a thermosensitive polymer which has mucoadhesive properties and increases the viscosity of systems. The analysis and optimization of in situ gelling systems were performed based on an experimental design and response surface methodology. The following formulation parameters were considered: X1 = chitosan concentration (0.5%, 1%), X2 = HPMC E 5 LV concentration (2%, 5%) and X3 = Chitosan/HPMC E 5 LV ratio (1/1, 2/1). In addition, the parameters to be optimized were represented by the contact angle (CA (°)), viscosity and cumulative percentage of bupivacaine hydrochloride released in vitro. The results indicate that the designed in situ gelling systems are suitable for bupivacaine prolonged ophthalmic release and overcome the principal disadvantages of the liquid’s ocular formulations. An immediate therapeutic effect corresponding to ocular anesthetic installation was assured in the first stage: burst bupivacaine release. In the second phase, the gradual drug release was assured for over 6 h. This drug release profile, together with the corresponding rheological profile and a collection of superficial properties for good ocular adhesion balanced with an adequate hydrophilic character, assured the desired quality of the attributes for the proposed systems. The system, based on chitosan 1%, HPMC E 5 LV 5% and a 1/1 polymer ratio, could be a solution for the proposed formulation of in situ gelling colloidal systems, since the viscosity of the system was within the range of the optimal viscosity of the eye, and the amount of bupivacaine hydrochloride released after 6 h was the highest at 69.55%.

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“…The response of the system is represented graphically in three dimensions, with highlighting of the interactions between the formulation factors [32].…”

Section: Optimization Of Colloidal Systems With In Situ Gelling Based On Chitosan and Hpmc E 5 LV Using Response Surface Analysismentioning

confidence: 99%

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

et al. 2021

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“…In the present study, the software Design-Expert 7.0.0 is used to evaluate the collective effect of four independent variables (pH, adsorbent dose, initial concentration, and contact time) in sets of 30 experiments. The variables have five levels; the details are presented in Table 1 [40].…”

Section: Statistical and Data Analysismentioning

confidence: 99%

“…A series of solutions with a Cd 2+ concentration of 25.39 mg/L (an optimized condition) and some common competing ions (Na + , Ca 2+ , Mg 2+ , Ba 2+ , Zn 2+ , Co 2+ , Mn 2+ , and Pb 2+ ) in different concentration ranges (5,10,15,20,40, and 100 mg/L) were prepared in this regard. Then, 40 mL of these solutions was added to 4.55 mg of the adsorbent at pH 5.75 for 21.50 min, which was an optimized condition provided by the software (Table 5).…”

Section: Adsorption Selectivitymentioning

confidence: 99%

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A comprehensive study on removal of cadmium from aqueous solution by using mesoporous SBA-15 functionalized by 1,5-diphenyl carbazide: experimental design, kinetic, thermodynamic, and isotherm aspects

Danesh-Khorasgani¹,

Faghihian²,

Givianrad³

et al. 2021

Comptes Rendus. Chimie

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“…The main goal of employing RSM method is to enhance the performance and the cost of experimental study by working less experiments. (Keramat and Zare-Dorabei, 2017;Saini et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Use of Response Surface Methodology for Optimization of Nickel Adsorption in an Aqueous Solution by Clay

Turki¹,

Boujelben²,

Bakari³

et al. 2021

American Journal of Environmental Sciences

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In this study, Scanning Electron Microscopy (SEM), X-ray diffraction and BET surface area (SBET) methods were employed to characterize the adsorbent. Response Surface Methodology (RSM) was consider as a good method to assess Ni adsorption treatment and Box-Behnken design was used to examine simultaneous the effects of different experimental variables (pH, adsorbent dosage, contact time). Experimental results showed high adsorption efficiency. Statistical analysis showed a high correlation coefficient (R 2 value 0.9578). It was showed that adsorption efficiency raised as contact time and adsorbent dosage raised. The best results were acquired with optimum conditions. A contact time of 120 min and an adsorbent dose of 0.5 mg L -1 give the highest adsorption capacity. The similarity between observed and predicted values sustains the relevance of the model to estimate the adsorption process. It was suggested that Langmuir and Freundlich isotherm models fitted for Nickel adsorption process (R 2 values ranged between 0.92 and 0.99). The results showed that adsorption efficiency increased as temperature increase. Mostly, Tunisian clay may be assessed as powerful adsorbent for the adsorption of Nickel from aqueous solution.

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Response surface methodology (RSM) for optimization of cadmium ions adsorption using C16-6-16 incorporated mesoporous MCM-41

Cited by 28 publications

References 26 publications

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

Development and Optimization of Chitosan-Hydroxypropyl Methylcellulose In Situ Gelling Systems for Ophthalmic Delivery of Bupivacaine Hydrochloride

A comprehensive study on removal of cadmium from aqueous solution by using mesoporous SBA-15 functionalized by 1,5-diphenyl carbazide: experimental design, kinetic, thermodynamic, and isotherm aspects

Use of Response Surface Methodology for Optimization of Nickel Adsorption in an Aqueous Solution by Clay

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