1986
DOI: 10.1002/jmv.1890190305
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Response to a hepatitis b polypeptide vaccine in micelle form in a young adult population

Abstract: Polypeptide micelles with relative molecular weights of 25,000 (p25) and 30,000 (gp30) daltons were prepared from native 22-nm hepatitis B surface antigen (HBsAg) particles. This p25/gp30 complex was alum-adsorbed, and three dosage levels (20 micrograms, 4 micrograms, and 0.8 micrograms) were administered at 0, 1, and 6 months to 51 human volunteers. Local and systemic reactions were clinically insignificant, and all vaccinees seroconverted, regardless of dose. As anticipated, antibody responses diminished as … Show more

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Cited by 35 publications
(34 citation statements)
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“…Seroconversion rates after the first injection were similar in groups A and B (Table 3). In another study, using dosages different from ours, no significant differences in the seroconversion rates were observed with doses of 40, 20, and 10 gg HBsAg [10]. On the other hand, in this latter investigation, the levels of anti-HBs after the booster injection were dose-dependent.…”
Section: Discussioncontrasting
confidence: 59%
See 1 more Smart Citation
“…Seroconversion rates after the first injection were similar in groups A and B (Table 3). In another study, using dosages different from ours, no significant differences in the seroconversion rates were observed with doses of 40, 20, and 10 gg HBsAg [10]. On the other hand, in this latter investigation, the levels of anti-HBs after the booster injection were dose-dependent.…”
Section: Discussioncontrasting
confidence: 59%
“…The detection of differences in genetic regulation could be facilitated, since it is well known that antibody responses are regulated on the single epitope level. As a consequence, compared with other studies [2,5,10,12,21], we observe a relatively high percentage (19%) of non-and low-responders and their immune system is now being studied.…”
Section: Discussionmentioning
confidence: 52%
“…38,39 Levels of diphtheria antitoxin were measured with a Vero cell culture assay, 40 and tetanus antitoxin was measured with an indirect, noncompetitive enzyme-linked immunoassay (EIA). Levels of antibody to PT and FHA were measured using an indirect, noncompetitive EIA.…”
Section: Methodsmentioning
confidence: 99%
“…At 3 weeks and at 1 year after the fourth inoculation, sera were obtained for anti-HBs titers, as determined by radioimmunoassay (AUSAB, Abbott Laboratories, North Chicago, Ill.). International units per liter were calculated according to the formulas developed by Hotlinger [9].…”
Section: Revaccination and Anti-hbs Titermentioning
confidence: 99%