Response to antituberculous chemotherapy after splenectomy

Nayyar, Vineet; Ramakrishna, B. S.; Mathew, Georgie; Williams, R. R.; Khanduri, P

doi:10.1111/j.1365-2796.1993.tb00653.x

Cited by 32 publications

(30 citation statements)

References 8 publications

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“…This set of data is in accordance with the clinical observation of a case of disseminated TB unresponsive to chemotherapy until splenectomy was performed [11]. In the patient splenomegaly with persisting pathological changes of the spleen on CTscan was documented.…”

Section: Discussionsupporting

confidence: 54%

Interleukin-12 as successful adjuvant in tuberculosis treatment

Greinert

Ernst²,

Schlaak³

et al. 2001

Eur Respir J

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Interleukin-12 as successful adjuvant in tuberculosis treatment. U. Greinert, M. Ernst, M. Schlaak, P. Entzian. #ERS Journals Ltd 2001. ABSTRACT: Interleukin-12 (IL-12) proved to be an effective and successful adjuvant to a standard antituberculotic medication in a patient suffering from progressive clinical tuberculosis (TB).IL-12 is a potent enhancer of interferon-c production which is necessary for killing intracellular bacteria like mycobacteria. This patient9s TB was progressive, although sensitivity to first-line antituberculotics was proven and medication was given as directly observed therapy over more than 8 months. The 3-month adjuvant therapy with IL-12 significantly and convincingly improved results.It is believed that this case, the first in the literature to describe adjuvant interleukin-12 therapy in tuberculosis, strongly encourages the study of adjuvant interleukin-12 therapy on a more systematic basis.

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Section: Discussionsupporting

confidence: 54%

Interleukin-12 as successful adjuvant in tuberculosis treatment

Greinert

Ernst²,

Schlaak³

et al. 2001

Eur Respir J

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“…12,18,19 Contradictory reports are also available favoring absence of response to antituberculous therapy without splenectomy. 20 Tuberculosis should be considered as one of the differential diagnosis in patients presenting with FUO and splenomegaly especially in areas where the disease is prevalent. Splenic tuberculosis can even affect immunocompetent individuals.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis of the Spleen as a Cause of Fever of Unknown Origin and Splenomegaly

Pottakkat¹,

Kumar²,

Rastogi³

et al. 2010

Gut Liver

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“…(lung 100%, liver 82%, spleen 75%, lymph nodes 55%, bone marrow 41%) . 4 The second form is the primary involvement of spleen which is extremely rare (the same as our patient). In English, French and German literature, from 1965 to 1992, just six cases were reported .…”

Section: Discussionmentioning

confidence: 99%

Splenic Tuberculosis: A Cause of Pyrexia of Unknown Origin Report of Two Cases

et al. 2013

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Tuberculosis of spleen is an extremely rare clinical entity. It often poses diagnostic difficulties as microbiological confirmation of diagnosis is not easy. We encountered two casas who presented with prolong fever but no other symptoms. Laboratory data provided no specific information for diagnosis. Abdominal ultrasonography revealed splenomegaly with multiple small hypoechoic lesions within the spleen. A diagnosis of isolated splenic tuberculosis was confirmed after a splenic puncture and histopathological examination.DOI: http://dx.doi.org/10.3329/jom.v14i1.14586 J MEDICINE 2013; 14 : 88-90

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Response to antituberculous chemotherapy after splenectomy

Abstract: A case of a 17-year-old Indian male with disseminated tuberculosis is reported. While on chemotherapy, he was detected to have splenic abscesses. The patient remained unresponsive to antituberculous drugs until a splenectomy was performed.

Cited by 32 publications

References 8 publications

Interleukin-12 as successful adjuvant in tuberculosis treatment

Interleukin-12 as successful adjuvant in tuberculosis treatment

Tuberculosis of the Spleen as a Cause of Fever of Unknown Origin and Splenomegaly

Splenic Tuberculosis: A Cause of Pyrexia of Unknown Origin Report of Two Cases

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