2018
DOI: 10.1021/acschemneuro.8b00423
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Response to Comment on “In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates”

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Cited by 5 publications
(4 citation statements)
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“…A recent study by Schoenberger et al 40 and the related commentary letters by McGinnity et al 41 and Sander et al 42 23 We believe that the combination of 60 Hz electrical stimulation to open and activate the NMDAR-ICs so allowing [ 18 F]GE-179 to enter and access the PCP site and blockade with S-ketamine during and after electrical stimulation effectively blocked these sites to [ 18 F] GE-179.…”
Section: Discussionmentioning
confidence: 86%
See 1 more Smart Citation
“…A recent study by Schoenberger et al 40 and the related commentary letters by McGinnity et al 41 and Sander et al 42 23 We believe that the combination of 60 Hz electrical stimulation to open and activate the NMDAR-ICs so allowing [ 18 F]GE-179 to enter and access the PCP site and blockade with S-ketamine during and after electrical stimulation effectively blocked these sites to [ 18 F] GE-179.…”
Section: Discussionmentioning
confidence: 86%
“…41 and Sander et al. 42 have discussed the difficulties of determining the in vivo specificity of [ 18 F]GE-179 to the NMDAR using pharmacological challenges. Schoenberger et al.…”
Section: Discussionmentioning
confidence: 99%
“…A study that used a blocking agent to investigate the specific binding of [ 18 F]GE-179 in rodents and primates did not find evidence of specificity to NMDAR [ 41 ]. However, this study co-administered anaesthetic agents which may also alter the availability of the target sites, complicating interpretation of the findings as tracer binding could have been altered by anaesthetic agents used in the control group [ 41 43 ]. Notwithstanding this, a recent study found that electrical stimulation designed to activate NMDAR induced significant increases in the uptake of [ 18 F]GE-179, and also that the NMDAR antagonist, ketamine, blocked this increase in uptake, indicating [ 18 F]GE-179 binds to NMDAR and is sensitive to changes in NMDAR activity [ 44 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, there are also studies in rodents and primates which have not used this stimulation method and do not find that NMDAR antagonists such as ketamine were able to block [ 18 F] GE-179 binding (Schoenberger et al, 2018). However, these studies co-administered anaesthetic agents which may interact with the NMDAR and, consequently, alter the sensitivity of these approaches to detect changes (McGinnity et al, 2018; Sander et al, 2018). Thus, while the in vitro evidence shows the tracer is specific to the NMDAR, there is some inconsistency in the in vivo evidence, potentially due to the use of anaesthetic agents that interact with NMDAR.…”
Section: Strengths and Limitationsmentioning
confidence: 99%