Response to Letter Regarding Article “Large Animal Models of Heart Failure: A Critical Link in the Translation of Basic Science to Clinical Practice”

Dixon, Jennifer A.; Spinale, Francis G.

doi:10.1161/circheartfailure.109.934430

Cited by 88 publications

(119 citation statements)

References 4 publications

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“…The rationale for using sheep heart was its documented physiological, functional, and anatomical similarities to human heart, as well as its lack of collateral coronary circulation that has made it a widely used animal model in the studies of myocardial infarction and heart failure. 11,12 To the best of our knowledge, this is the first study to compare mechanical behavior and microstructure of heart chambers through a paired comparison approach.…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

2016

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Mechanical properties of the cardiac tissue play an important role in normal heart function. The goal of this study was to determine the passive mechanical properties of all heart chambers through a paired comparison study in an ovine model. Ovine heart was used due its physiological and anatomical similarities to human heart. A total of 189 specimens from anterior and posterior portions of the left and right ventricles, atria, and appendages underwent biaxial mechanical testing. A Fung-type strain energy function was used to fit the experimental data. Tissue behavior was quantified based on the magnitude of strain energy, as indicator of tissue stiffness, at equibiaxial strains of 0.10, 0.15, and 0.20. Statistical analysis revealed no significant difference in strain energy storage between anterior and posterior portions of each chamber, except for the right ventricle where strain energy storage in the posterior specimens were higher than the anterior specimens. Additionally, all chambers from the left side of the heart had significantly higher strain energy storage than the corresponding chambers on the right side. Furthermore, the highest to lowest stored strain energy were associated with ventricles, appendages, and atria, respectively. Microstructure of tissue specimens from different chambers was also compared using histology.

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Section: Introductionmentioning

confidence: 99%

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

2016

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“…Experimental animal models of HF seem to be a rational alternative for the comprehensive studies of the whole spectrum of the natural history of HF [4], including the initial sequence of pathophysiological changes finally leading to over, symptomatic HF. As HF affects unfavourably almost all organs and systems in the body, the other advantage of animal models of HF is an unrestricted availability for detailed examinations of myocardial tissue and virtually all peripheral tissues [4].…”

Section: Introductionmentioning

confidence: 99%

Development of porcine model of chronic tachycardia-induced cardiomyopathy

Pasławska

Gajek

Kiczak

et al. 2011

International Journal of Cardiology

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“…Because timing of anti-inflammatory interventions and patient selection will be critical to the success of anti-inflammatory interventions after MI, large animal models and advanced imaging technologies will be crucial before making the transition to clinical application [67,68].…”

Section: Resultsmentioning

confidence: 99%

Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing

et al. 2012

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The wound healing response after myocardial infarction (MI) involves a cascade of molecular and cellular events that lead to a replacement of the necrotic area with a collagen-rich scar. Clearance of necrotic debris by neutrophils, monocytes, and macrophages is a critical component of infarct healing; however, tight control and timely repression of this inflammatory response is important to prevent excessive tissue degradation leading to infarct expansion and heart failure. Genetic ablation or blockade of anti-inflammatory pathways tends to be detrimental after MI, whereas genetic ablation of pro-inflammatory pathways tends to be beneficial. Accordingly, therapies enhancing endogenous anti-inflammatory pathways or blocking endogenous pro-inflammatory pathways have been found to improve wound healing and to reduce the risk of heart failure in rodent models of acute MI. Besides their scavenger function, inflammatory cells promote healing by stimulating angiogenesis and granulation tissue formation via paracrine factors. Moreover, signaling mediators that are active in inflammatory cells may be active also in non-inflammatory cell types involved in infarct healing. Some anti-inflammatory interventions are therefore deleterious. However, interventions that carefully adjust the balance between the essential and detrimental facets of inflammation may provide new therapeutic opportunities for patients with large MIs who continue to be at risk of developing heart failure, despite modern reperfusion and anti-remodeling strategies.

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Response to Letter Regarding Article “Large Animal Models of Heart Failure: A Critical Link in the Translation of Basic Science to Clinical Practice”

Cited by 88 publications

References 4 publications

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

Biomechanical Properties and Microstructure of Heart Chambers: A Paired Comparison Study in an Ovine Model

Development of porcine model of chronic tachycardia-induced cardiomyopathy

Anti-inflammatory mechanisms and therapeutic opportunities in myocardial infarct healing

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