Response to Metabolically Supported Chemotherapy (MSCT) with weekly carboplatin/paclitaxel in advanced stage/metastatic (Stage IV) non-small cell lung cancer: A survival, efficacy and tolerability analysis

Iyikesici, M. S.; Slocum, Abdul Kadir; Türkmen, Esma; Berkarda, Ferhan Bulent

doi:10.1093/annonc/mdx091.042

Cited by 1 publication

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“…Furthermore, multiple studies from investigators in Turkey have evaluated the use of metabolically supported chemotherapy (MSCT), which involves a combination of fasting and administration of pharmacological doses of insulin to induce hypoglycemia at the time of standard chemotherapy, along with adherence to a ketogenic diet in advanced gastric, pancreatic, and lung cancer [68][69][70]. These studies demonstrated remarkably high PFS and OS rates, but notably did not include control groups.…”

Section: Chemotherapy and Other Therapiesmentioning

confidence: 99%

Monitoring and Modulating Diet and Gut Microbes to Enhance Response and Reduce Toxicity to Cancer Treatment

Knisely

Seo

Wargo

et al. 2023

Cancers

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The gut microbiome comprises a diverse array of microbial species that have been shown to dynamically modulate host immunity both locally and systemically, as well as contribute to tumorigenesis. In this review, we discuss the scientific evidence on the role that gut microbes and diet play in response and toxicity to cancer treatment. We highlight studies across multiple cancer cohorts that have shown an association between particular gut microbiome signatures and an improved response to immune checkpoint blockade, chemotherapy, and adoptive cell therapies, as well as the role of particular microbes in driving treatment-related toxicity and how the microbiome can be modulated through strategies, such as fecal transplant. We also summarize the current literature that implicate high fiber and ketogenic diets in improved response rates to immunotherapy and chemotherapy, respectively. Finally, we discuss the relevance of these findings in the context of patient care, advocate for a holistic approach to cancer treatment, and comment on the next frontier of targeted gut and tumor microbiome modulation through novel therapeutics, dietary intervention, and precision-medicine approaches.

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Section: Chemotherapy and Other Therapiesmentioning

confidence: 99%