Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'

Response to 'Statins accelerate the onset of collagen type II-induced arthritis in mice'-authors' reply

“…We thank Mathieu and colleagues for their interest in our recent publication [1] and for reporting their very interesting experiments showing that intraperitoneal but not subcutaneous simvastatin inhibits arthritis progression in the mouse collagen-induced arthritis (CIA) model [2]. These results are in line with those of Palmer and colleagues, who showed that intraperitoneal but not oral simvastatin administration inhibited pre-existing CIA [3].…”

“…According to Mathieu and colleagues, in our study we found that 'oral atorvastatin and pravastatin had no effect on the arthritis score after CIA induction' [2]. This statement is not correct, however.…”

“…The findings from Mathieu and colleagues [2] underscore that statins have an immunomodulatory activity. Altogether, one may conclude that the outcome of statins on immune responses may depend on the type of statin, the dose, and the route of administration.…”