Response to ‘The essential role of dermatology publications in enhancing professional diversity, equity and inclusion’

Gribbin, H; Lee, R C; Betz‐Stablein, Brigid; Soyer, H. Peter

doi:10.1111/bjd.21629

Cited by 3 publications

(1 citation statement)

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“…The innate typology angle (ITA), a numerical value which accurately correlates with biologically efficient doses of UV radiation (i.e. doses required to induce sunburn) (Del Bino & Bernerd, 2013) (CIELAB 1976 System), was calculated using VECTRA mirror software algorithmic L* and b* wavelength data (Gribbin et al, 2022). Other phenotypic characteristics including hair and eye colour were also recorded.…”

Section: Figurementioning

confidence: 99%

MITF E318K: A rare homozygous case with multiple primary melanoma

Wallingford,

Maas,

Howard

et al. 2023

Pigment Cell Melanoma Res

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MITF E318K moderates melanoma risk. Only five MITF E318K homozygous cases have been reported to date, one in association with melanoma. This novel report uses 3D total‐body‐photography (TBP) to describe the dermatological phenotype of a homozygous MITF E318K individual. The case, a 32‐year‐old male, was diagnosed with his first of six primary melanomas at 26 years of age. Five melanomas were located on the back and one in the groin. Two were superficial spreading. Three arose from pre‐existing naevi and one was a rare naevoid melanoma. 3D‐TBP revealed a high naevus count (n = 162) with pigmentation varying from light to dark. Most naevi generally (n = 90), and large (>5 mm diameter) and clinically atypical naevi specifically were located on the back where sun damage was mild. In contrast, naevi count was low (n = 25 total) on the head/neck and lower limbs where sun damage was severe. Thus, melanoma location correlated with naevi density, rather than degree of sun damage. In addition to the MITF E318K homozygosity, there was heterozygosity for four other moderate‐risk variants, which may contribute to melanoma risk. Further research is warranted to explore whether melanomas in E318K heterozygous and other homozygotes coincide with regions of high naevi density as opposed to sun damage. This could inform future melanoma screening/surveillance.

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Section: Figurementioning

confidence: 99%