Restenosis and its determinants in first and repeat coronary angioplasty

Abstract

KEY WORDS: PTCA, restenosis, repeat PTCA, PTCA outcome determinants. (PTCA) Since its introduction' 12 ' successful percutaneous long-term success of PTCA. Reported restenosis transluminal coronary angioplasty (PTCA) has rates (14-47%) vary, depending in part on the denbeen shown to relieve angina and myocardial nition used, but according to the larger series' 18 " 22 ', ischaemia as assessed by exercise electrocardiogone patient in three with successful PTCA must raphy 13 ', thallium scintigraphy* 3 ' 4 ', and measureexpect recurrence, most of them within 6-8 months ment of coronary blood flow and myocardial after the intervention. Repeat PTCA has been metabolism' 5 ' 6 '. The original indications' 2 ' have been done with a higher primary success rate and fewer expanded' 7 " 171 . But regardless of selection criteria, complications than the initial procedure. Nevertherestenosis with recurrence of myocardial ischaemia less, there remains a substantial rate of second and symptoms remains the major problem limiting recurrences' 23 " 251 . The presence of angina as an indicator for restenosis has a predictive accuracy of only 56% Submitted for publication on 23 June 1986 and in revised form 21 after first and 67% after Second PTCA according tO OctobCTl986 the NHLBI report" 8231 . One patient in four with For the period that this work was carried out, Dr Rapold was restenosis has no chest pain. In a population at high supported by a grant oftheSwisi National Science Foundation. Restenosis is the main problem limiting long-term success of percutaneous transluminal coronary angioplasty

Tumor Necrosis Factor Alpha and Interleukin 10 Promoter Polymorphisms in Mexican Patients with Restenosis After Coronary Stenting

“…Restenosis is a major complication that occurs after percutaneous transluminal coronary angioplasty (PTCA) in about 30-32% of patients and after intracoronary stent placement in 12-32% of patients (Weiczorek and Tsongalis 2001;Rapold et al 1987;Serruys et al 1994Serruys et al , 1998Sigwart et al 1987). Some differences exist in the mechanism involved in this phenomenon in PTCA and stenting.…”

The interleukin 1B–511 polymorphism is associated with the risk of developing restenosis after coronary stenting in Mexican patients

“…The treatment strategies are coronary artery bypass grafting, percutaneous transluminal coronary angioplasty (PTCA), and intracoronary stent. However, after PTCA, restenosis occurs in about 30 to 32% of patients and after intracoronary stent placement in 12 to 32% of patients [2][3][4][5][6]. Substantial differences exist in the mechanisms of restenosis between conventional PTCA and stenting.…”

Long-Term Prognosis in Achieving a `Stent-Like' Result From Balloon Angioplasty

“…A number of separate studies have found that percentage residual stenosis is an important factor in restenosis even after taking other factors into account using multivariate regression analysis. [11][12][13][14][15][16][17] Similarly, our study demonstrated that a stent-like result was a predictive factor for reducing restenosis.…”