Resting metabolic rate, body composition, and serum leptin concentrations in a free-living elderly population

Neuhäuser‐Berthold, Monika; Herbert, BM; Luhrmann, PM; Sultemeier, AA; Blum, WF; Frey, Joachim; Hebebrand, Johannes

doi:10.1530/eje.0.1420486

Cited by 29 publications

(21 citation statements)

References 39 publications

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“…REEs divided by FFM (see Table 1) of this study were near by those (unit is kcal/24 h/kg, men: 28.4, women: 31.2-33.5, obese men: 29.2, obese women: 30.7) in previous studies [Tataranni et al, 1994;Weststrate et al, 1990]. Table 3 shows that REE is strongly associated with body composition (FM and FFM) and age except for in the elderly women, which supports the findings of the previous studies [Armellini et al, 2000;Karhunen et al, 1997;Luhrmann et al, 2001;Neuhauser-Berthold et al, 2000]. Thus, the REE adjusted for FFM, FM and age was used in this study.…”

Section: Discussionsupporting

confidence: 88%

Relationships of Resting Energy Expenditure with Body Fat Distribution and Abdominal Fatness in Japanese Population.

Okura¹,

Koda

Ando³

et al. 2003

J. Physiol. Anthropol.

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Body fat distribution and abdominal fatness are indicators of risks for coronary heart disease. However, the relationships between resting energy expenditure (REE) and the body fat distribution or the abdominal fatness are unclear. We examined the relationships of REE with whole-body fat distribution (waist, hip and waist-to-hip ratio: WHR) and abdominal fatness (intra-abdominal fat: IF and subcutaneous fat: SF) after adjustment for body composition. 451 men and 471 women were subdivided into two groups, 40-59 years: middle-aged group and 60-79 years: elderly group. REE was measured by an indirect calorimetry system. Percentage of fat mass (%FM), fat mass (FM) and fat-free mass (FFM) were assessed by a dual-energy x-ray absorptiometry method. The IF area (IFA) and SF area (SFA) at the level of the umbilicus were measured using computed tomography. Circumference of waist and hip were measured in a standing position. The WHR, waist circumference and SFA did not significantly (pϾ0.05) associate with the REE after adjusting for FM, FFM and age in any of the groups. The adjusted REE was significantly and inversely correlated with hip (rϭϪ0.159, pϽ0.05) and IFA (rϭϪ0.131, pϽ0.05) in the elderly men. These results suggest that lower REE may contribute to greater hip and IFA rather than WHR and waist in elderly men.

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Section: Discussionsupporting

confidence: 88%

Relationships of Resting Energy Expenditure with Body Fat Distribution and Abdominal Fatness in Japanese Population.

Okura¹,

Koda

Ando³

et al. 2003

J. Physiol. Anthropol.

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“…As has been shown previously, we observed a strong positive relationship between serum leptin concentrations and FM at any measured time point. [52][53][54][55] After 1 y WM, unsuccessful subjects showed an increase in their leptin concentrations compared to after weight loss, as a consequence of their regain in FM. Successful subjects did not regain FM and thus kept their leptin concentrations reduced.…”

Section: Discussionmentioning

confidence: 98%

Categorical strategies based on subject characteristics of dietary restraint and physical activity, for weight maintenance

Vogels

Westerterp-Plantenga

2005

Int J Obes

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OBJECTIVE:The aim of this study was to investigate the effect of categorical strategies based on subject-specific characteristics of dietary restraint and physical activity, on weight maintenance (WM) in overweight and obese subjects, after a very low calorie diet (VLCD). Furthermore, find predictors of WM that can be important in the context of obesity treatment. METHODS: In all, 120 subjects (age: 49.079.8 y, BMI 31.073.8 kg/m 2 ) followed a VLCD (2.1 MJ/day) for 6 weeks in a freeliving situation, followed by a period of 1 y WM. Body weight (BW), body composition, leptin concentration, dietary restraint and physical activity were determined right before (t0) and after (t1) the VLCD, after 3 months (t2) and after 1 y (t3). During WM, subjects were divided into four categories of WM guidelines (dietary, activity, diet þ activity, placebo), taking their capability measured during weight loss and their preference for particular guidelines into account. RESULTS: BW loss during VLCD was 7.073.1 kg. After 1 y follow-up, BW regain was 56.3755.0%, without significant differences between the four groups. With respect to measured capability during weight loss, subjects with an increased dietary restraint (F1 of the Three Factor Eating Questionnaire) had less BW regain than subjects with an increased physical activity (Baecke questionnaire) (35.5753.2 vs 68.5746.4%, Po0.05). Moreover, activity guidelines promoted WM in dietary disciplined subjects compared to activity-related disciplined subjects (%regain: 25.2 vs 74.3%, Po0.05). Subjects receiving guidelines that were opposite to their preference showed a better WM than subjects receiving preferred guidelines. After 1 y WM, 21 subjects were successful (o10% BW regain) and 99 unsuccessful (Z10% BW regain). At baseline, these groups were significantly different in BMI (resp. 32.774.9 vs 30.773.5 kg/m 2 , Po0.05), waist circumference (106.5714.0 vs 100.6711.2 cm, Po0.05) and fat mass (FM) (35.2710.6 vs 32.176.6%, P ¼ 0.06). Finally, successful subjects appeared to spare fat-free mass (FFM) to a greater extent than unsuccessful subjects. CONCLUSION: After weight loss, type of guidelines (dietary, activity, placebo) is not related to the magnitude of WM, whereas guidelines opposite to the subject's capability and preference are related. These only reach successful WM (490%) in originally dietary disciplined subjects who are supported by characteristics such as a relatively high baseline BMI, waist circumference and FM, together with the ability to spare FFM.

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“…The effect was such that the metabolic rates of the oldest dogs were on average only half those of dogs that were 1-2 years old. An age-related decline in resting metabolism has been reported many times for humans (Poehlman, 1993;Poehlman et al, 1993a,b;Van Pelt et al, 1997, 2001Hughes et al, 1998;Neuhauser-Berthold et al, 2000), although such declines are not universally observed (e.g. Promislow & Haselkorn, 2002;Sukhotin et al, 2002).…”

Section: Resting Metabolic Ratementioning

confidence: 97%

Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy

Speakman

Acker²,

Harper³

2003

Aging Cell

137

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SummaryWe measured body composition and resting metabolic rates (RMR) of three dog breeds (Papillons, mean body mass 3.0 kg ( n = 35), Labrador retrievers, mean body mass 29.8 kg ( n = 35) and Great Danes, mean body mass 62.8 kg ( n = 35)) that varied between 0.6 and 14.3 years of age. In Papillons, lean body mass (LBM) increased with age but fat mass (FBM) was constant; in Labradors, both LBM and FBM were constant with age, and in Great Danes, FBM increased with age but LBM was constant. FBM averaged 14.8% and 15.7% of body mass in Papillons and Labradors, respectively. Great Danes were leaner and averaged only 10.5% FBM. Pooling the data for all individuals, the RMR was significantly and positively associated with LBM and FBM and negatively associated with age. Once these factors had been taken into account there was still a significant breed effect on RMR, which was significantly lower in Labradors than in the other two breeds. Using the predictive multiple regression equation for RMR and the temporal trends in body composition, we modelled the expenditure of energy (at rest) over the first 8 years of life, and over the entire lifespan for each breed. Over the first 8 years of life the average expenditure of energy per kg LBM were 0.985, 0.675 and 0.662 GJ for Papillons, Labradors and Great Danes, respectively. This energy expenditure was almost 60% greater for the smallest compared with the largest breed. On average, however, the life expectancy for the smallest breed was a further 6 years (i.e. 14 years in total), whereas for the largest breed it was only another 6 months (i.e. 8.5 years in total).Total lifetime expenditure of energy at rest per kg LBM averaged 1.584, 0.918 and 0.691 GJ for Papillons, Labradors and Great Danes, respectively. In Labradors, total daily energy expenditure, measured by the doubly labelled water method in eight animals, was only 16% greater than the observed RMR. High energy expenditure in dogs appears positively linked to increased life expectancy, contrary to the finding across mammal species and within exotherms, yet resembling observations in other intraspecific studies. These contrasting correlations suggest that metabolism is affecting life expectancy in different ways at these different levels of enquiry.

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Resting metabolic rate, body composition, and serum leptin concentrations in a free-living elderly population

Cited by 29 publications

References 39 publications

Relationships of Resting Energy Expenditure with Body Fat Distribution and Abdominal Fatness in Japanese Population.

Relationships of Resting Energy Expenditure with Body Fat Distribution and Abdominal Fatness in Japanese Population.

Categorical strategies based on subject characteristics of dietary restraint and physical activity, for weight maintenance

Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy

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