Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T

Northrup, Benjamin E.; McCommis, Kyle S.; Zhang, Haosen; Ray, Shuddhadeb; Woodard, Pamela K.; Gropler, Robert J.; Zheng, Jie

doi:10.1186/1532-429x-10-53

Cited by 37 publications

(34 citation statements)

References 37 publications

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“…Using first-pass perfusion MRI, Hsu, et al (24) found resting MBF in healthy human subjects to be 1.02 ± 0.22 mL/g/min. Past myocardial ASL studies using breath hold reported normal perfusion values to be 0.990 ± 0.302 mL/g/min at 1.5 T, 1.058 ± 0.187 and 1.36 ± 0.40 mL/g/min at 3.0T (4, 25). Our MBF data (1.00±0.55 with MoCo and 1.42±0.74 mL/g/min without MoCo) are comparable to data obtained with PET, first-pass perfusion MRI and breath hold myocardial ASL.…”

Section: Discussionmentioning

confidence: 93%

Estimation of perfusion and arterial transit time in myocardium using free‐breathing myocardial arterial spin labeling with navigator‐echo

Wang

Avants

et al. 2010

Magnetic Resonance in Med

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Arterial spin labeling (ASL) provides noninvasive measurement of tissue blood flow, but sensitivity to motion has limited its application to imaging of myocardial blood flow. Although different cardiac phases can be synchronized using electrocardiography triggering, breath holding is generally required to minimize effects of respiratory motion during ASL scanning, which may be challenging in clinical populations. Here a freebreathing myocardial ASL technique with the potential for reliable clinical application is presented, by combining ASL with a navigator-gated, electrocardiography-triggered TrueFISP readout sequence. Dynamic myocardial perfusion signals were measured at multiple delay times that allowed simultaneous fitting of myocardial blood flow and arterial transit time. With the assist of a nonrigid motion correction program, the estimated mean myocardial blood flow was 1.00 6 0.55 mL/g/min with a mean transit time of~400 msec. The intraclass correlation coefficient of repeated scans was 0.89 with a mean within subject coefficient of variation of 22%. Perfusion response during mild to moderate stress was further measured. The capability for noninvasive, free-breathing assessment of myocardial blood flow using ASL may offer an alternative approach to first-pass perfusion MRI for clinical evaluation of patients with coronary artery disease. Magn Reson Med 64:1289-1295,

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Section: Discussionmentioning

confidence: 93%

Estimation of perfusion and arterial transit time in myocardium using free‐breathing myocardial arterial spin labeling with navigator‐echo

Wang

Avants

et al. 2010

Magnetic Resonance in Med

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“…ASL has also shown its potential to quantify human MBF [25,26]. Cine-ASL has recently been proposed as an original approach to assess MBF [27,28].…”

Section: Introductionmentioning

confidence: 99%

In vivo characterization of rodent cyclic myocardial perfusion variation at rest and during adenosine-induced stress using cine-ASL cardiovascular magnetic resonance

Troalen

Capron

Bernard

et al. 2014

Journal of Cardiovascular Magnetic Resonance

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BackgroundAssessment of cyclic myocardial blood flow (MBF) variations can be an interesting addition to the characterization of microvascular function and its alterations. To date, totally non-invasive in vivo methods with this capability are still lacking. As an original technique, a cine arterial spin labeling (ASL) cardiovascular magnetic resonance approach is demonstrated to be able to produce dynamic MBF maps across the cardiac cycle in rats.MethodHigh-resolution MBF maps in left ventricular myocardium were computed from steady-state perfusion-dependent gradient-echo cine images produced by the cine-ASL sequence. Cyclic changes of MBF over the entire cardiac cycle in seven normal rats were analyzed quantitatively every 6ms at rest and during adenosine-induced stress.ResultsThe study showed a significant MBF increase from end-systole (ES) to end-diastole (ED) in both physiological states. Mean MBF over the cardiac cycle within the group was 5.5 ± 0.6 mL g-1 min-1 at rest (MBFMin = 4.7 ± 0.8 at ES and MBFMax = 6.5 ± 0.6 mL g-1 min-1 at ED, P = 0.0007). Mean MBF during adenosine-induced stress was 12.8 ± 0.7mL g-1 min-1 (MBFMin = 11.7±1.0 at ES and MBFMax = 14.2 ± 0.7 mL g-1 min-1 at ED, P = 0.0007). MBF percentage relative variations were significantly different with 27.2 ± 9.3% at rest and 17.8 ± 7.1% during adenosine stress (P = 0.014). The dynamic analysis also showed a time shift of peak MBF within the cardiac cycle during stress.ConclusionThe cyclic change of myocardial perfusion was examined by mapping MBF with a steady-pulsed ASL approach. Dynamic MBF maps were obtained with high spatial and temporal resolution (6ms) demonstrating the feasibility of non-invasively mapping cyclic myocardial perfusion variation at rest and during adenosine stress. In a pathological context, detailed assessment of coronary responses to infused vasodilators may give valuable complementary information on microvascular functional defects in disease models.

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“…There has been preliminary work on myocardial ASL in humans (5)(6)(7)(8)(9). These preliminary studies have demonstrated the existence of an ASL signal in the heart, and while some have demonstrated signal increases with pharmacological stress, none has reported sufficient image quality and measurement consistency to provide useful diagnostic information in individual patients.…”

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confidence: 96%

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

Zun

Varadarajan

Pai

et al. 2011

JACC: Cardiovascular Imaging

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Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T

Cited by 37 publications

References 37 publications

Estimation of perfusion and arterial transit time in myocardium using free‐breathing myocardial arterial spin labeling with navigator‐echo

Estimation of perfusion and arterial transit time in myocardium using free‐breathing myocardial arterial spin labeling with navigator‐echo

In vivo characterization of rodent cyclic myocardial perfusion variation at rest and during adenosine-induced stress using cine-ASL cardiovascular magnetic resonance

Arterial Spin Labeled CMR Detects Clinically Relevant Increase in Myocardial Blood Flow With Vasodilation

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