Resting state functional connectivity in anorexia nervosa

Phillipou, Andrea; Abel, Larry A; Castle, David; Hughes, Matthew; Nibbs, Richard; Gurvich, Caroline; Rossell, Susan L.

doi:10.1016/j.pscychresns.2016.04.008

Cited by 43 publications

(39 citation statements)

References 27 publications

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“…In line with several previous publications, we find largely decreased intra-and interregional rsfMRI measures in acute AN in bilateral prefrontal, sensorimotor, left parietal, left temporal, bilateral precuneal and insular regions (Ehrlich et al, 2015;Favaro et al, 2012;Gaudio et al, 2015Gaudio et al, , 2018Geisler et al, 2016;Haynos et al, 2019;Kullmann et al, 2014;Phillipou et al, 2016;Scaife et al, 2017;Seidel et al, 2019). In contrast to some previous studies, we do not find increases of intraregional (Seidel et al, 2019) or interregional FC and activity (Biezonski et al, 2016;Boehm et al, 2014;Cha et al, 2016;Lee et al, 2014;Uniacke et al, 2019).…”

Section: Discussionsupporting

confidence: 89%

Recovery-associated resting-state activity and connectivity alterations in Anorexia nervosa

Lotter

Polier

Offermann

et al. 2020

Preprint

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Background: Previous studies provided controversial insight on the impact of starvation, disease status as well as of underlying grey matter volume (GMV) changes on resting-state functional magnetic resonance imaging (rsfMRI) alterations in anorexia nervosa (AN). Here we adapt a combined longitudinal and cross-sectional approach to disentangle the effects of these factors on resting-state alterations in AN. Methods: Overall, 87 subjects were included in the study: adolescent patients with acute AN scanned at inpatient admission (N = 22) and at discharge (N = 21), 21 patients recovered from AN and two groups of healthy age-matched controls (both N = 22). Whole-brain measures of resting-state activity and functional connectivity were computed (Network Based Statistics, Global Correlation, Integrated Local Correlation, fractional Amplitude of Low Frequency Fluctuations) to assess rsfMRI alterations over the course of AN treatment before and after controlling for underlying GMV. Results: Patients with acute AN displayed strong and widespread prefrontal, sensorimotor, parietal, temporal, precuneal and insular reductions of resting-state connectivity and activity. All alterations were independent of GMV and were largely normalized in short- and absent in long-term recovered AN. Conclusions: Resting-state fMRI alterations in AN constitute acute and GMV independent presumably starvation-related phenomena. All alterations found here normalized over the course of recovery without evidence for possible preexisting trait- or remaining 'scar'-effects.

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Section: Discussionsupporting

confidence: 89%

Recovery-associated resting-state activity and connectivity alterations in Anorexia nervosa

Lotter

Polier

Offermann

et al. 2020

Preprint

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“…Greater cortical thinning could, in turn, increase vulnerability to AN by disrupting communication between and/or within networks subserving perception of and/or attention to body shape and size. Altered resting-state functional connectivity, consistent with this hypothesis, has been reported in AN;Phillipou et al (2016) reported reduced resting-state functional connectivity between visual association and sensorimotor areas in women with acute AN, andFavaro et al (2012) andScaife, Godier, Filippini, Harmer & Park (2017) reported reduced resting-state functional connectivity within ventral and lateral visual networks, respectively, in women with acute and remitted AN.…”

supporting

confidence: 78%

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Miles

Kaplan

et al. 2018

Preprint

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Brain-behavior relationships that could provide insight into risk-associated pathophysiology have not been thoroughly assessed in anorexia nervosa (AN). Therefore, we sought to identify grey and white matter signatures of AN symptoms and risk factors (trait anxiety, set-shifting impairment) in a sample enriched for AN vulnerability, including acute and remitted AN patients and their unaffected sisters (n = 72, aged 18 -48 years). MRI/DTI data were acquired on a 3T scanner and processed with Freesurfer and FSL TBSS. Relationships between clinical variables of interest and regional subcortical volume, vertexwise cortical surface architecture (thickness, surface area, local gyrification), and voxel-wise white matter microstructure (FA, MD) were tested with separate linear regressions, including age, BMI, lifetime AN diagnosis, and intracranial volume as covariates, where appropriate. Significance was determined using a Bonferroni-corrected threshold, p(t) ≤ 0.001. We detected distinct associations linking AN symptoms to lateral occipital cortical thickness and insular/cingulate gyrification and trait anxiety to lingual cortical thickness and superior parietal gyrification, and we detected overlapping associations linking AN symptoms and set-shifting impairment to frontoparietal gyrification. No other brain-behavior relationships emerged. Our findings suggest that variations in site-specific cortical morphology could give rise to core features of AN and shared temperamental and cognitive-behavioral risk factors for AN.

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“…Subtypes effects have not been systematically assessed in prior research. Some studies have not reported subtype analyses (Biezonski et al, ; Favaro et al, ; Phillipou et al, ) and other studies only included AN‐R (Haynos et al, ). One study had unbalanced numbers in each subtype group which limited between‐group comparisons (Boehm et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Gaudio et al () identified decreased connectivity in the ECN in adolescents with new‐onset illness, while others have found abnormal connectivity within the Frontoparietal Network (FPN; analogous to the ECN) in ill and recovered participants with AN (Boehm et al, ). On the other hand, several studies have not found significant differences in the networks implicated in the triple network model in underweight individuals with AN (Boehm et al, ; Scaife, Godier, Filippini, Harmer, & Park, ) or participants recovered from AN relative to HC (Boehm et al, ; Phillipou et al, ; Scaife et al, ). One study that used FNC to measure cross‐network connectivity of these systems found no difference in network interactions between the SN, DMN, and FPN among women recovered from AN and HC (Boehm et al, ).…”

Section: Introductionmentioning

confidence: 99%

Resting‐state connectivity within and across neural circuits in anorexia nervosa

et al. 2018

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Introduction Obsessional thoughts and ritualized eating behaviors are characteristic of Anorexia Nervosa (AN), leading to the common suggestion that the illness shares neurobiology with obsessive–compulsive disorder (OCD). Resting‐state functional connectivity MRI (rs‐fcMRI) is a measure of functional neural architecture. This longitudinal study examined functional connectivity in AN within the limbic cortico‐striato‐thalamo‐cortical (CSTC) loop, as well as in the salience network, the default mode network, and the executive control network (components of the triple network model of psychopathology). Methods Resting‐state functional connectivity MRI scans were collected in unmedicated female inpatients with AN (n = 25) and healthy controls (HC; n = 24). Individuals with AN were scanned before and after weight restoration and followed for one month after hospital discharge. HC were scanned twice over the same timeframe. Results Using a seed‐based correlation approach, individuals with AN had increased connectivity within the limbic CSTC loop when underweight, only. There was no significant association between limbic CSTC connectivity and obsessive–compulsive symptoms or prognosis. Exploratory analyses of functional network connectivity within the triple network model showed reduced connectivity between the salience network and left executive control network among AN relative to HC. These abnormalities persisted following weight restoration. Conclusions The CSTC findings suggest that the neural underpinnings of obsessive–compulsive symptoms may differ from those of OCD. The inter‐network abnormalities warrant examination in relation to illness‐specific behaviors, namely abnormal eating behavior. This longitudinal study highlights the complexity of the neural underpinnings of AN.

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Resting state functional connectivity in anorexia nervosa

Cited by 43 publications

References 27 publications

Recovery-associated resting-state activity and connectivity alterations in Anorexia nervosa

Recovery-associated resting-state activity and connectivity alterations in Anorexia nervosa

Structural neuroimaging signatures of anorexia nervosa features in a mixed sample enriched for disease vulnerability

Resting‐state connectivity within and across neural circuits in anorexia nervosa

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