Resting-state Functional Magnetic Resonance Imaging in Presurgical Functional Mapping

Dierker, Donna L.; Roland, Jarod L.; Kamran, Mudassar; Rutlin, Jerrel; Hacker, Carl D.; Marcus, Daniel S.; Milchenko, Mikhail; Miller‐Thomas, Michelle M.; Benzinger, Tammie L.S.; Snyder, Abraham Z.; Leuthardt, Eric C.; Shimony, Joshua S.

doi:10.1016/j.nic.2017.06.011

Cited by 59 publications

(53 citation statements)

References 49 publications

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“…Nonetheless, an emerging body of research suggests these network characteristics may depict key properties that relate to functional integrity and prediction of change at the individual patient level (Dierker et al, 2017;Doucet, Rider, et al, 2015;McCormick et al, 2014;McCormick, Quraan, Cohn, Valiante, & McAndrews, 2013;Sair, Agarwal, & Pillai, 2017;Zhou, Liu, Ng, & Wang, 2017).…”

Section: Discussionmentioning

confidence: 99%

Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection

Audrain

Barnett

McAndrews

2018

Human Brain Mapping

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While anterior temporal lobe (ATL) resection is an effective treatment for temporal lobe epilepsy, surgery on the dominant hemisphere is associated with variable decline in confrontation naming. Accurate prediction of naming impairment is critical to inform clinical decision making, and while there has been some degree of success using task-based functional MRI (fMRI) paradigms, there remains a growing interest in the predictive utility of resting-state connectivity as it allows for relatively shorter scans with low task demands. Our objective was to assess the relationship between measures of preoperative resting-state connectivity and postoperative naming change in patients following left ATL resection. We compared the resting language network connectivity of each patient to a normative healthy control template using a novel measure called "matrix similarity," and found that patients with more abnormal global language-network connectivity-particularly of regions spared from surgery-showed greater postoperative naming decline than those with normative patterns of connectivity. When we interrogated the degree centrality of to-be-resected regions in a more targeted approach of the pathological temporal lobe, we found that greater functional integration of those regions with the rest of the language network at rest was related to greater decline in naming following surgery. Finally, we found that matrix similarity was a better predictor of postoperative outcome than degree within to-be-resected regions, network clustering, modularity, and language task fMRI laterality. We provide some of the first evidence that using this novel measure, a relatively short preoperative resting scan can be exploited to inform naming ability following ATL resection.

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Section: Discussionmentioning

confidence: 99%

Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection

Audrain

Barnett

McAndrews

2018

Human Brain Mapping

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“…In regards to resting-state fMRI, our results suggest that both neuronal desynchronization and neurovascular disruption could contribute to apparent changes in fMRI-based measures of 'functional connectivity' related to tumor progression (Hadjiabadi et al, 2018) (Dierker et al, 2017). Nevertheless, these results do suggest a firm physiological basis for studies which have noted the ability of resting state fMRI data to delineate glioma tumor boundaries (Bowden et al, 2018) (Chow et al, 2016) (Agarwal et al, 2016).…”

Section: Progressive Disruption Of Neurovascular Couplingmentioning

confidence: 67%

Glioma-induced alterations in neuronal activity and neurovascular coupling during disease progression

Montgomery

Kim

Dovas

et al. 2019

Preprint

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AbstractDiffusely infiltrating gliomas are known to cause alterations in cortical function, vascular disruption and seizures. These neurological complications present major clinical challenges, yet their underlying mechanisms and causal relationships to disease progression are poorly characterized. Here, we followed glioma progression in awake Thy1-GCaMP6f mice using in-vivo wide-field optical mapping to monitor alterations in both neuronal activity and functional hemodynamics. The bilateral synchrony of spontaneous neuronal activity in glioma-infiltrated cortex gradually decreased, while neurovascular coupling was also progressively disrupted compared to uninvolved cortex. Over time, mice developed diverse patterns of high amplitude discharges and eventually generalized seizures that begin at the infiltrative margin of the tumors. Interictal and seizure events exhibited positive neurovascular coupling in uninfiltrated cortex, however glioma-infiltrated regions exhibited inverted hemodynamic responses driving seizure-evoked hypoxia. These results reveal a landscape of complex physiological interactions occurring during glioma progression and present new opportunities for exploring new biomarkers and therapeutic targets.Highlights-Glioma disrupts neural synchrony between bilateral cortical regions.-WFOM reveals frequent interictal discharges and seizures during glioma progression.-Tumor development is accompanied by local changes in neurovascular coupling.-Altered neurovascular coupling drives hypoperfusion of the tumor during seizures.

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“…Rs-FMRI has been investigated as a primary technique for presurgical mapping in patients who are unable to comply with task paradigms. 7,32 To circumvent the challenge of seed placement in brains that have been distorted by lesions, prior studies have used independent component analysis (ICA)based rs-FMRI and compared it with task-based FMRI in the language system. Tie and colleagues compared these 2 techniques in 34 healthy volunteers; the study was primarily focused on the feasibility of defining the language network using ICA.…”

Section: Discussionmentioning

confidence: 99%

Presurgical resting‐state functional MRI language mapping with seed selection guided by regional homogeneity

Hsu

Chen

Hou

et al. 2019

Magnetic Resonance in Med

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Purpose Resting‐state functional MRI (rs‐FMRI) has shown potential for presurgical mapping of eloquent cortex when a patient’s performance on task‐based FMRI is compromised. The seed‐based analysis is a practical approach for detecting rs‐FMRI functional networks; however, seed localization remains challenging for presurgical language mapping. Therefore, we proposed a data‐driven approach to guide seed localization for presurgical rs‐FMRI language mapping. Methods Twenty‐six patients with brain tumors located in left perisylvian regions had undergone task‐based FMRI and rs‐FMRI before tumor resection. For the seed‐based rs‐FMRI language mapping, a seeding approach that integrates regional homogeneity and meta‐analysis maps (RH+MA) was proposed to guide the seed localization. Canonical and task‐based seeding approaches were used for comparison. The performance of the 3 seeding approaches was evaluated by calculating the Dice coefficients between each rs‐FMRI language mapping result and the result from task‐based FMRI. Results With the RH+MA approach, selecting among the top 6 seed candidates resulted in the highest Dice coefficient for 81% of patients (21 of 26) and the top 9 seed candidates for 92% of patients (24 of 26). The RH+MA approach yielded rs‐FMRI language mapping results that were in greater agreement with the results of task‐based FMRI, with significantly higher Dice coefficients (P < .05) than that of canonical and task‐based approaches within putative language regions. Conclusion The proposed RH+MA approach outperformed the canonical and task‐based seed localization for rs‐FMRI language mapping. The results suggest that RH+MA is a robust and feasible method for seed‐based functional connectivity mapping in clinical practice.

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Resting-state Functional Magnetic Resonance Imaging in Presurgical Functional Mapping

Cited by 59 publications

References 49 publications

Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection

Language network measures at rest indicate individual differences in naming decline after anterior temporal lobe resection

Glioma-induced alterations in neuronal activity and neurovascular coupling during disease progression

Presurgical resting‐state functional MRI language mapping with seed selection guided by regional homogeneity

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